Abstract: The present disclosure relates to methods for treating lichen planus (e.g., lichen planopilaris, mucosal lichen planus, cutaneous lichen planus) using Interleukin (IL)-17 antagonists, e.g., secukinumab. Also disclosed herein are IL-17 antagonists, e.g., IL-17 antibodies, such as secukinumab, for treating patients having lichen planus (e.g., lichen planopilaris, mucosal lichen planus, cutaneous lichen planus), as well as medicaments, dosing regimens, pharmaceutical formulations, dosage forms, and kits for use in the disclosed uses and methods.

Abstract: A flexible probe includes a probe body having a distal end and a proximal end, and comprises at least one flexible nanoelectronic thread having a distal end and a proximal end and a length therebetween, the nanoelectronic thread comprising at least one electrode positioned on a top surface of the nanoelectronic thread, and at least one nanoscale wire is partially encapsulated, having a first portion electrically connected to at least one of the electrodes and a second portion surrounded by a dielectric insulator, the probe further including at least one external trace electrically connected to the at least one nanoscale wire at the proximal end of the at least one nanoelectronic thread, the at least one external trace having a width larger than the width of the at least one nanoscale wire, and an interface connector near the proximal end of the probe body, electrically connected to the at least one electrode via the at least one nanoscale wire and the at least one external trace, wherein the at least one nano

Abstract: A cosmetic composition is provided which includes niacinamide, a carboxylic acid bearing structurant, and particles of a condensation polymerized polyamide, the polyamide having an amine value no lower than 0.3 and an HLB value of at least 16. The polyamide particles prevent interaction between niacinamide and the carboxylic acid/salt structurant thereby inhibiting skinfeel complexation and/or phase separation that would be adverse to skinfeel.

Abstract: A cosmetic composition is provided which is a vanishing cream structured with 0.5 to 50% by weight of C12-C20 fatty acid, 0.1 to 20% by weight of C12-C20 fatty acid salt and hydrophilic composite particles with organic sunscreen agent. The hydrophilic composite particles are formed as a composite of sunscreen agent and a binder in a relative weight ratio of about 5:1 to about 1:10. The composition exhibits relatively high SPF photoprotection while maintaining excellent skinfeel aesthetics.

Abstract: A cosmetic composition is provided which includes niacinamide, a carboxylic acid bearing structurant, and particles of a condensation polymerized polyamide, the polyamide having an amine value no lower than 0.3 and an HLB value of at least 16. The polyamide particles prevent interaction between niacinamide and the carboxylic acid/salt structurant thereby inhibiting skinfeel complexation and/or phase separation that would be adverse to skinfeel.

Abstract: A cosmetic composition is provided which is a vanishing cream structured with 0.5 to 50% by weight of C12-C20 fafty acid, 0.1 to 20% by weight of C12-C20 fatty acid salt and hydrophilic composite particles with organic sunscreen agent. The hydrophilic composite particles are formed as a composite of sunscreen agent and a binder in a relative weight ratio of about 5:1 to about 1:10. The composition exhibits relatively high SPF photoprotection while maintaining excellent skinfeel aesthetics.