Patents by Inventor Xiaoling Zheng
Xiaoling Zheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 12156369Abstract: Techniques are described for managing temperature in an autonomous vehicle. An exemplary method comprises performing autonomous driving operations that operate the autonomous vehicle in an autonomous mode, receiving one or more messages from a temperature sensor associated with an electrical device located on or in the autonomous vehicle while the autonomous vehicle is operated in the autonomous mode, determining a cooling technique to reduce the temperature of electrical device, and performing the cooling technique.Type: GrantFiled: July 18, 2023Date of Patent: November 26, 2024Assignee: TUSIMPLE, INC.Inventors: Kaixin Zheng, Xiaoling Han, Zehua Huang, Todd Skinner
-
Publication number: 20240375708Abstract: Techniques are described for managing redundant steering system for a vehicle. A method includes sending a first control command that instructs a first motor coupled to a steering wheel in a steering system to steer a vehicle, receiving, after sending the first control command, a speed of the vehicle, a yaw rate of the vehicle, and a steering position of the steering wheel, determining, based at least on the speed and the yaw rate, an expected range of steering angles that describes values within which the first motor is expected to steer the vehicle based on the first control command, and upon determining that the steering position of a steering wheel is outside the expected range of steering angles, sending a second control command that instructs a second motor coupled to the steering wheel in the steering system to steer the vehicle.Type: ApplicationFiled: July 25, 2024Publication date: November 14, 2024Inventors: Kaixin ZHENG, Xiaoling HAN, Zehua HUANG
-
Publication number: 20240347131Abstract: A cancer detection model and a construction method therefor, and a reagent kit, relating to the technical field of cancer detection. The method comprises: performing whole genome sequencing on plasma free DNA to mine nucleosome distribution features, terminal sequence features, and fragment size distribution features that can be applied to cancer detection; constructing classification models of the three indicators to obtain prediction scores of each indicator for a sample; then integrating these scores using a logistic regression model, and adding copy number variation feature information to obtain an ultimate classification and prediction model.Type: ApplicationFiled: March 8, 2022Publication date: October 17, 2024Applicant: BERRY ONCOLOGY CO., LTD.Inventors: Qingzheng ZHANG, Lu ZHENG, Fuming SUN, Jian BAI, Yin WANG, Xiaoling LI, Lin WU
-
Patent number: 12049270Abstract: Techniques are described for managing redundant steering system for a vehicle. A method includes sending a first control command that instructs a first motor coupled to a steering wheel in a steering system to steer a vehicle, receiving, after sending the first control command, a speed of the vehicle, a yaw rate of the vehicle, and a steering position of the steering wheel, determining, based at least on the speed and the yaw rate, an expected range of steering angles that describes values within which the first motor is expected to steer the vehicle based on the first control command, and upon determining that the steering position of a steering wheel is outside the expected range of steering angles, sending a second control command that instructs a second motor coupled to the steering wheel in the steering system to steer the vehicle.Type: GrantFiled: January 20, 2023Date of Patent: July 30, 2024Assignee: TUSIMPLE, INC.Inventors: Kaixin Zheng, Xiaoling Han, Zehua Huang
-
Patent number: 12037648Abstract: The present disclosure belongs to the field of livestock molecular biotechnology, and provides kits and methods for pedigree division and paternity testing of domestic pigs. The kits and methods specifically select 14 SSR loci of domestic pigs, especially Anqing six-end-white pigs, and synthesize primers for corresponding loci. Through capillary electrophoresis detection of the ear tissue DNA of 98 Anqing six-end-white pigs, the count of effective alleles, heterozygosity, polymorphism information content, and genetic distance, and exclusion probability at each locus are calculated, the pedigree division of domestic pigs, especially Anqing six-end-white pigs, and paternity testing are conducted. The cumulative exclusion probability of 14 microsatellite loci is 99%.Type: GrantFiled: July 11, 2022Date of Patent: July 16, 2024Assignee: ANHUI AGRICULTURAL UNIVERSITYInventors: Yueyun Ding, Xiaoling Ding, Zongjun Yin, Xudong Wu, Xiaodong Zhang, Xianrui Zheng, Zijing Ling, Qiong Chen, Yinhui Hou, Chengcheng Kong
-
Publication number: 20240102336Abstract: A control method for a charging port cover of a vehicle including a charging end assembly. The charging end assembly includes a charging port having a fast charging port and a slow charging port and a charging port cover having a fast charging port cover and a slow charging port cover. The method includes: when a charging port cover opening signal is received, controlling both the fast charging port cover and the slow charging port cover to be opened; when one of the fast charging port and the slow charging port is detected to be inserted with a plug-in end of a charging device, generating a charging port cover closing instruction; and controlling the charging port cover corresponding to the charging port into which the plug-in end is not inserted to be closed according to the charging port cover closing instruction.Type: ApplicationFiled: December 8, 2023Publication date: March 28, 2024Inventors: Canlin ZHANG, Xiaoling ZHENG
-
Patent number: 11884691Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.Type: GrantFiled: May 18, 2023Date of Patent: January 30, 2024Assignee: Hongene Biotech CorporationInventors: Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Mufa Zou, Xiaoyang Guan, Xiaoling Zheng, David Yu, Ruiming Zou, Aldrich N. K. Lau
-
Publication number: 20230340000Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.Type: ApplicationFiled: May 18, 2023Publication date: October 26, 2023Inventors: Wing C. POON, Gang ZHAO, Gengyu DU, Yun-Chiao YAO, Mufa ZOU, Xiaoyang GUAN, Xiaoling ZHENG, David YU, Ruiming ZOU, Aldrich N.K. LAU
-
Patent number: 11692001Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.Type: GrantFiled: August 26, 2022Date of Patent: July 4, 2023Assignee: Hongene Biotech CorporationInventors: Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Mufa Zou, Xiaoyang Guan, Xiaoling Zheng, David Yu, Ruiming Zou, Aldrich N. K. Lau
-
Patent number: 11649260Abstract: Embodiments of the present application relate to N-acetylgalactosamine-conjugated nucleosides. In particular, the N-acetylgalactosamine is installed on the nucleobase of the nucleosides through a wide variety of linkers. Methods of making N-acetylgalactosamine-conjugated nucleosides are also disclosed herein. N-acetylgalactosamine is a well-defined liver-targeted moiety and N-acetylgalactosamine-conjugated nucleosides may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.Type: GrantFiled: June 16, 2022Date of Patent: May 16, 2023Assignee: Hongene Biotech CorporationInventors: Xiaoyang Guan, David Yu, Ruiming Zou, Xiaoling Zheng, John Liu, Aldrich N. K. Lau, Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao
-
Publication number: 20230100220Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.Type: ApplicationFiled: August 26, 2022Publication date: March 30, 2023Inventors: Wing C. POON, Gang ZHAO, Gengyu DU, Yun-Chiao YAO, Mufa ZOU, Xiaoyang GUAN, Xiaoling ZHENG, David YU, Ruiming ZOU, Aldrich N.K. LAU
-
Publication number: 20230034284Abstract: Embodiments of the present application relate to N-acetylgalactosamine-conjugated nucleosides. In particular, the N-acetylgalactosamine is installed on the nucleobase of the nucleosides through a wide variety of linkers. Methods of making N-acetylgalactosamine-conjugated nucleosides are also disclosed herein. N-acetylgalactosamine is a well-defined liver-targeted moiety and N-acetylgalactosamine-conjugated nucleosides may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.Type: ApplicationFiled: June 16, 2022Publication date: February 2, 2023Inventors: Xiaoyang Guan, David Yu, Ruiming Zou, Xiaoling Zheng, John Liu, Aldrich N.K. Lau, Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao
-
Publication number: 20230027257Abstract: The invention provides for compositions comprising phosphorous containing tricyclic compounds, including phthalazin-1(2H)-one derivatives. The compounds are potent inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), particularly PARP-1 and potentially PARP-2. The also show good cellular activity in inhibiting poly(ADP-ribose) oligomer formation. The compounds may be useful as mono-therapy or in combination with other therapeutic agents in the treatment conditions where PARP is implicated, such as cancer, inflammatory diseases and ischemic conditions. Thus, also provided are methods for the treatment of a condition where PARP is implicated comprising administering to an effective amount of a compound of the invention to an individual in need thereof.Type: ApplicationFiled: February 14, 2022Publication date: January 26, 2023Inventors: Wang SHEN, Jack MAUNG, Aimin ZHANG, Xiaoling ZHENG
-
Patent number: 11524956Abstract: The invention provides alkyne substituted quinazoline compounds, such as compounds of the formula (I), which are irreversible ErbB kinase inhibitors. The compounds are useful in the treatment of diseases and disorders where ErbB kinase activity is implicated such as a hyperproliferative disorder (e.g., cancer).Type: GrantFiled: March 27, 2020Date of Patent: December 13, 2022Assignee: Newgen Therapeutics, Inc.Inventors: Wang Shen, Aimin Zhang, Jack Maung, Xiaoling Zheng
-
Patent number: 11248013Abstract: The invention provides for compositions comprising phosphorous containing tricyclic compounds, including phthalazin-1(2H)-one derivatives. The compounds are potent inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), particularly PARP-1 and potentially PARP-2. The also show good cellular activity in inhibiting poly(ADP-ribose) oligomer formation. The compounds may be useful as mono-therapy or in combination with other therapeutic agents in the treatment conditions where PARP is implicated, such as cancer, inflammatory diseases and ischemic conditions. Thus, also provided are methods for the treatment of a condition where PARP is implicated comprising administering to an effective amount of a compound of the invention to an individual in need thereof.Type: GrantFiled: October 28, 2019Date of Patent: February 15, 2022Assignee: Rakovina Therapeutics Inc.Inventors: Wang Shen, Jack Maung, Aimin Zhang, Xiaoling Zheng
-
Publication number: 20210047303Abstract: The invention provides alkyne substituted quinazoline compounds, such as compounds of the formula (I), which are irreversible ErbB kinase inhibitors. The compounds are useful in the treatment of diseases and disorders where ErbB kinase activity is implicated such as a hyperproliferative disorder (e.g., cancer).Type: ApplicationFiled: March 27, 2020Publication date: February 18, 2021Inventors: Wang SHEN, Aimin ZHANG, Jack MAUNG, Xiaoling ZHENG
-
Publication number: 20200299315Abstract: The invention provides lor compositions comprising phosphorous containing tricyclic compounds, including phthalazin-1(2H)-one derivatives. The compounds arc potent inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), particularly PARP-1 and potentially PARP-2. The also show good cellular activity in inhibiting poly(ADP-ribose) oligomer formation. The compounds may be useful as mono-therapy or in combination with other therapeutic agents in the treatment conditions where PARP is implicated, such as cancer, inflammatory diseases and ischemic conditions. Thus, also provided are methods for the treatment of a condition where PARP is implicated comprising administering to an effective amount of a compound of the invention to an individual in need thereof.Type: ApplicationFiled: October 28, 2019Publication date: September 24, 2020Inventors: Wang SHEN, Jack MAUNG, Aimin ZHANG, Xiaoling ZHENG
-
Publication number: 20190382382Abstract: The invention provides alkyne substituted quinazoline compounds, such as compounds of the formula (I), which are irreversible ErbB kinase inhibitors. The compounds are useful in the treatment of diseases and disorders where ErbB kinase activity is implicated such as a hyperproliferative disorder (e.g., cancer).Type: ApplicationFiled: January 18, 2019Publication date: December 19, 2019Inventors: Wang SHEN, Aimin ZHANG, Jack MAUNG, Xiaoling ZHENG
-
Patent number: 10426762Abstract: The present invention provides, among other things, compounds represented by the general Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, R2, and R3 are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.Type: GrantFiled: June 9, 2017Date of Patent: October 1, 2019Assignee: COCRYSTAL PHARMA, INC.Inventors: Sam S. Lee, Wang Shen, Xiaoling Zheng, Irina C. Jacobson
-
Publication number: 20180094010Abstract: The invention provides for compositions comprising phosphorous containing tricyclic compounds, including phthalazin-1(2H)-one derivatives. The compounds are potent inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), particularly PARP-1 and potentially PARP-2. The also show good cellular activity in inhibiting poly(ADP-ribose) oligomer formation. The compounds may be useful as mono-therapy or in combination with other therapeutic agents in the treatment conditions where PARP is implicated, such as cancer, inflammatory diseases and ischemic conditions. Thus, also provided are methods for the treatment of a condition where PARP is implicated comprising administering to an effective amount of a compound of the invention to an individual in need thereof.Type: ApplicationFiled: June 15, 2017Publication date: April 5, 2018Inventors: Wang SHEN, Jack MAUNG, Aimin ZHANG, Xiaoling ZHENG