Patents by Inventor Xiaolong Wang
Xiaolong Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12357321Abstract: An osteotomy guide (100,500,600) guides cutting of a bone (300). The guide (100,500,600) has an anterior end (106,506,606) and a posterior end (108,508,608) that are spaced from one another along a transverse direction. The guide (100,500,600) has an inner surface (102,502,602) that faces the bone (300), and an outer surface (104,504,604) opposite the inner surface (102,502,602) along an outer direction (Do). The guide (100,500,600) includes a transverse guide surface (138,538,638) that extends along a transverse axis (AT) along the transverse direction so as to define a transverse cutting path into the bone (300). The guide (100,500,600) includes an ascending guide surface (134,534,634) that extends along an ascending axis (AA) along an ascending direction so as to define an ascending cutting path into the bone (300). The transverse and ascending axes (AT,AA) intersect one another.Type: GrantFiled: August 23, 2019Date of Patent: July 15, 2025Assignee: DePuy Synthes Products, Inc.Inventors: Mingjun Zhang, Qiang Xu, Wenhao Qi, Weiwei Xiang, Xiaolong Wang
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Publication number: 20250215017Abstract: The present application relates to a TGF-? inhibitor compound and its use. Specifically, the present application discloses a compound represented by formula (I) or formula (II), an isotopically labeled compound thereof, an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or an isomer mixture thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof, or a metabolite thereof. The present application also relates to an application of the above compound in medicine.Type: ApplicationFiled: February 7, 2025Publication date: July 3, 2025Inventors: Liang LU, Xiao LIU, Saisai ZHAO, Longzheng ZHANG, Hai HUANG, Jixuan ZHANG, Junjie ZHU, Xiaolong WANG, Jiaxin CHEN, Shancun LING, Xinwei LIAO
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Publication number: 20250197480Abstract: Disclosed are a nanobody targeting influenza A virus nucleoprotein and an application thereof, and a nucleic acid encoding the nanobody. The present disclosure obtains one nanobody targeting influenza A virus nucleoprotein through construction of a nanobody phage library and phage screening technology. The nanobody targeting influenza A virus nucleoprotein is a VHH antibody fragment having an amino acid sequence shown in SEQ ID NO:1-SEQ ID NO:2. The nanobody in the present disclosure can specifically bind to influenza A virus nucleoprotein, and can be applied to the detection and analysis of influenza A virus, and has broad application prospects in the fields of early warning of the epidemic or outbreak of influenza A virus, as well as the detection of influenza A virus in the environment or human body.Type: ApplicationFiled: December 2, 2024Publication date: June 19, 2025Applicant: NANJING UNIVERSITYInventors: Yi Luo, Shixiang Yang, Wenjin Hu, Xiaolong Wang, Shengyang Wang, Huai Lin, Xiang Long
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Publication number: 20250188155Abstract: Disclosed are a preparation method and application of a single-chain antibody fragment targeting SARS-COV-2 nucleocapsid protein, aiming to provide a single-chain antibody fragment with high affinity and strong specificity. The present disclosure obtains three single-chain antibody fragments targeting SARS-COV-2 nucleocapsid protein through construction of a nanobody phage library and phage screening technology. The single-chain antibody fragment consists of a heavy chain variable region, a 15aa connecting peptide, and a light chain variable region connected in sequence, and has an amino acid sequence shown in SEQ ID NO: 1-SEQ ID NO: 3. The single-chain antibody fragment in the present disclosure has excellent binding performance and specificity with the SARS-COV-2 nucleocapsid protein, can be applied to a variety of immunoassay platforms of the SARS-COV-2, and has broad application prospects in the field of SARS-COV-2 detection.Type: ApplicationFiled: November 19, 2024Publication date: June 12, 2025Applicant: NANJING UNIVERSITYInventors: Yi Luo, Wenjin Hu, Shixiang Yang, Xiaolong Wang, Shengyang Wang, Huai Lin, Xiang Long
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Publication number: 20250189525Abstract: Disclosed are a preparation method and application of a nanobody targeting dengue virus NS1 protein. The nanobody targeting dengue virus NS1 protein is a VHH antibody, which is obtained by constructing a nanobody phage library through phage screening technology, and has an amino acid sequence shown in SEQ ID NO: 1. The nanobody in the present disclosure exhibits high affinity and specificity when being bound to the dengue virus NS1 protein, and has advantages of good stability and low cost compared with monoclonal antibodies. Therefore, the nanobody in the present disclosure can be produced on a large scale, and has bright application prospects in the field of dengue virus detection and analysis.Type: ApplicationFiled: November 21, 2024Publication date: June 12, 2025Applicant: NANJING UNIVERSITYInventors: Yi Luo, Shixiang Yang, Wenjin Hu, Xiaolong Wang, Shengyang Wang, Huai Lin, Xiang Long
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Patent number: 12327184Abstract: A method, a computer system, and a computer program product for using distinct paths with cross connections for distinct tasks to prevent catastrophic forgetting in class-incremental scenarios. Embodiments of the present invention may include receiving one or more tasks sequentially. Embodiments of the present invention may include applying one or more shareable blocks to the one or more tasks. Embodiments of the present invention may include learning one or more distinct paths for the one or more tasks. Embodiments of the present invention may include adding one or more cross connections between the one or more tasks. Embodiments of the present invention may include adding an aggregation block to collect one or more outputs from the distinct paths of each of the one or more tasks. Embodiments of the present invention may include providing a prediction.Type: GrantFiled: July 8, 2020Date of Patent: June 10, 2025Assignee: International Business Machines CorporationInventors: Yu Tian, Xiaolong Wang, Qinghan Xue, Steven Nicholas Eliuk, Xin Guo
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Patent number: 12324591Abstract: An osteotomy guide (100) includes an inner surface (102) that faces the bone (300), and an outer surface (104) opposite the inner surface (102) along an outward direction (Do). The inner surface (102) defines proximal and distal bone contacting regions (118,120) that are spaced from one another by a gap (124) that extends into the inner surface (102) towards the outer surface (104). The guide (100) includes an ascending guide surface (134) that extends along an ascending direction so as to define an ascending cutting path into the bone (300). The guide (100) includes a transverse guide surface (138) that extends along a transverse direction so as to define a transverse cutting path into the bone (300).Type: GrantFiled: April 12, 2019Date of Patent: June 10, 2025Assignee: DePuy Synthes Products, Inc.Inventors: Qiang Xu, Wenhao Qi, Mingjun Zhang, Weiwei Xiang, Xiaolong Wang
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Publication number: 20250179094Abstract: The present application relates to TGF-?inhibitor compounds and its use. Specifically, the present application discloses a compound represented by formula (I), an isotopically labeled compound thereof, an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or an isomer mixture thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof, or a metabolite thereof. The present application also relates to an application of the above compound in medicine.Type: ApplicationFiled: February 7, 2025Publication date: June 5, 2025Inventors: Liang LU, Saisai ZHAO, Longzheng ZHANG, Hai HUANG, Jixuan ZHANG, Junjie ZHU, Xiaolong WANG, Jiaxin CHEN, Shancun LING, Xinwei LIAO
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Patent number: 12292692Abstract: The present application discloses an image stitching method for a stitching product, which includes: step 1: providing a chip design layout of the stitching product; step 2: designing a mask layout according to the chip design layout, including: step 21: setting unit mask images; step 22: merging logic images or cutting path images of adjacent areas between unit regions together to set corresponding peripheral mask images; step 23: merging the same peripheral mask images into one; step 24: constituting a mask layer by using the unit mask images and each peripheral mask image, and forming the mask layout on a mask; step 3: performing repeated exposure to form the stitching product. The present application can reduce the number of mask images, the number of times of exposure and the time of exposure.Type: GrantFiled: August 25, 2022Date of Patent: May 6, 2025Assignee: Shanghai Huali Microelectronics CorporationInventors: Xiaobin Zhu, Haichang Zheng, Lijun Chen, Xiaolong Wang, Yu Zhang
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Patent number: 12293273Abstract: A method, a computer program product, and a computer system fuse features for multi-modal classifications for a plurality of modality inputs. The method includes receiving a request indicative of the modality inputs to be selected. The method includes performing an embeddings level fusion operation to concatenate features from the modality inputs. The method includes performing a multi-modal discriminative feature level fusion operation that integrates feature representations learned by applying different network structures on the modality inputs. The method includes determining weights of the concatenated features and the feature representations based on a measure of the concatenated features and the feature representations indicative of affecting a final prediction performance. The method includes generating fused features for the modality inputs based on the concatenated features, the feature representations, and the weights.Type: GrantFiled: July 14, 2020Date of Patent: May 6, 2025Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Xiaolong Wang, Qinghan Xue, Abhishek Kolagunda, Steven Nicholas Eliuk
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Publication number: 20250105421Abstract: A battery pack and a vehicle. The battery pack comprises a plurality of battery cells, a sealing cover, a tray, one or more insulating layers, and at least one connecting sheet, wherein the tray is coupled to the sealing cover to define an accommodating cavity; the plurality of battery cells are disposed in the accommodating cavity; the side of each battery cell facing away from the sealing cover is provided with a first explosion-proof valve; each insulating layer is disposed on the side of the battery cell facing away from the sealing cover; the connecting sheet is disposed on the insulating layer; the battery cells are electrically coupled by means of the connecting sheet; and each insulating layer is provided with a gas emission portion configured to enable the first explosion-proof valve in communication with an external environment.Type: ApplicationFiled: December 11, 2024Publication date: March 27, 2025Inventors: Zhengyuan Liao, Xiaolong Wang, Zhipei Lu, Xufeng Liu, Zenan Sun
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Publication number: 20250081774Abstract: The display substrate comprises a display area and a peripheral area surrounding the display area. The display substrate comprises: a substrate, a first and second conductive layers located on the substrate and sequentially arranged in the direction away from the substrate, and a first organic insulating layer located between the first and second conductive layers. The first conductive layer comprises a plurality of first metal wires extending in a first direction. The second conductive layer comprises a plurality of second metal wires extending in the first direction. In the peripheral area, the first organic insulating layer is divided, and the edge of the first organic insulating layer extends in a second direction and forms a first step. The second direction intersects with the first direction. The first step comprises at least one protruding structure and at least one recess structure located between the adjacent second metal wires.Type: ApplicationFiled: July 31, 2023Publication date: March 6, 2025Inventors: Chaojun ZENG, Baosheng HE, Xiaolong WANG, Minghui WANG, Quan LIU
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Patent number: 12213767Abstract: Provided is a video-based method and system for accurately estimating heart rate and facial blood volume distribution, and the method mainly comprises the following steps: firstly, carrying out face detection of video frame containing human face, and extracting face image sequence and face key position points sequence in time dimension; secondly, compressing these sequence of face image and face key position points to obtain the facial signals in time dimension; thirdly, estimating facial blood volume distribution by facial signals mentioned in third step; finally, estimating heart rate values by using model based on deep learning technology and the spectrum analysis method respectively, then fusing the estimation results by Kalman filter to promote the accuracy of heart rate estimation.Type: GrantFiled: March 17, 2022Date of Patent: February 4, 2025Assignee: ZHEJIANG UNIVERSITYInventors: Hujun Bao, Xiaogang Xu, Xiaolong Wang
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Publication number: 20250036431Abstract: This application provides a service widget display method, an electronic device, and a storage medium. The method includes: receiving a first operation of a user in a first state; displaying a first service widget in response to the first operation, where the first service widget includes a first target service; receiving a second operation of the user in a second state; and displaying a second service widget in response to the second operation, where the second service widget includes a second target service; and the first target service is different from the second target service, and one or more of the following information of the electronic device in the first state and the second state are different: a current location and current time of the electronic device.Type: ApplicationFiled: December 9, 2022Publication date: January 30, 2025Inventors: Canyang Han, Xiaolong Wang, Hua Huang
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Patent number: 12156252Abstract: The present disclosure discloses a data processing method, apparatus, device, and computer-readable storage medium, wherein the method is performed by a transmitting terminal, and the method includes: in response to a type of a data packet to enter a transmission queue of the transmitting terminal being a preset type, determining a timing when the data packet is expected to enter the transmission queue of the transmitting terminal as an expected transmitting timing; and in response to a duration from current timing to the expected transmitting timing being within a preset range, initiating a channel contention operation related to transmitting the data packet, wherein the channel contention operation related to transmitting the data packet includes carrier sensing, waiting for a distributed inter-frame spacing DIFS, and waiting for a back-off window.Type: GrantFiled: January 13, 2024Date of Patent: November 26, 2024Assignee: TP-LINK CORPORATION LIMITEDInventor: Xiaolong Wang
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Publication number: 20240369635Abstract: A generator fault detection method based on the characteristics of air gap magnetic flux density includes the following steps: S1: installing detection devices on a generator and building a test platform; S2: obtaining an air gap magnetic flux density signal through the detection devices; S3: transforming a time domain signal of the magnetic flux density into a frequency domain signal by using a fast Fourier transform; S4: judging if the generator has an air gap eccentricity or a stator inter-turn short circuit fault through the comparison of time domain and frequency domain; S5: obtaining a value of air gap magnetic flux density by calculation, selecting and then comparing a root mean square value of magnetic flux density under different working conditions with the root mean square value of magnetic flux density under normal condition to determine a fault degree.Type: ApplicationFiled: June 16, 2023Publication date: November 7, 2024Applicant: North China Electric Power University (Baoding)Inventors: Yuling HE, Wen ZHANG, Yong LI, Yifan BAI, Mingxing XU, Xiaolong WANG
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Patent number: 12129520Abstract: Disclosed is a DNA sequencing method. The DNA sequencing method of this invention comprises: (1) adding a tag sequence at the 3? terminus of the DNA to be sequenced so as to form a DNA to be sequenced including the tag sequence, the nucleotide sequence of said tag sequence being the reverse complement of the nucleotide sequence of the sequencing primer; (2) mixing the DNA to be sequenced including the tag sequence and the sequencing primer so as to form a product having a 5? terminus double strand and a single main strand; (3) after step (2) is completed, the product is mixed separately with dATP, dCTP, dTTP, and dGTP to obtain four systems, each system is separately added to a single-molecule device modified by a DNA polymerase, and electric signals are read. Experiments verify that the method of this invention performs DNA sequencing and has important application value.Type: GrantFiled: October 30, 2017Date of Patent: October 29, 2024Assignee: PEKING UNIVERSITYInventors: Xuefeng Guo, Xiaolong Wang, Haina Ci
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Publication number: 20240317760Abstract: The present application relates to TRK kinase inhibitor compounds and its use. Specifically, the present application discloses a compound represented by formula (I), an isotopically labeled compound thereof, an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or an isomer mixture thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof, or a metabolite thereof. The present application also relates to an application of the above compound in medicine.Type: ApplicationFiled: June 21, 2022Publication date: September 26, 2024Inventors: Liang LU, Hai Huang, Longzheng Zhang, Saisai Zhao, Jixuan Zhang, Xiaolong Wang, Junjie Zhu, Xinwei Liao, Jiaxin Chen, Shancun Ling
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Publication number: 20240307485Abstract: Provided is a method of inducing or accelerating a healing process of wound in a subject in need thereof.Type: ApplicationFiled: May 27, 2024Publication date: September 19, 2024Inventors: Faming ZHANG, Yuan SHEN, Minglong HU, Yao YU, Xiaolong WANG, Along ZHAO
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Patent number: 12061118Abstract: The present invention provides a calibration apparatus, system and method for an in-vehicle camera. The calibration apparatus for an in-vehicle camera includes: a body, where at least one distinctive mark arranged at intervals along a first direction and at least one heating member arranged at intervals along a second direction are disposed on the body. The distinctive mark is configured to be recognized by a common camera, and the heating member is configured to generate heat so as to be recognized by an infrared camera. According to the calibration apparatus, system and method for an in-vehicle camera provided in the present invention, during calibration, a common camera can recognize the distinctive mark, and therefore, the common camera can be calibrated; the heating member may generate heat so as to be recognized by an infrared camera, and therefore, the infrared camera is calibrated.Type: GrantFiled: October 16, 2020Date of Patent: August 13, 2024Assignee: AUTEL INTELLIGENT TECHNOLOGY CORP., LTD.Inventors: Yong Chen, Xinguang Tang, Xiaolong Wang