Patents by Inventor Xiaolu HAN

Xiaolu HAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Masking chimeric antigen receptor T cells for tumor-specific activation
    Patent number: 10822419
    Abstract: The invention is directed to a masked chimeric antigen receptor, comprising: (a) a masking peptide; (b) one or more antigen-specific targeting domains; (c) an extracellular spacer domain; (d) a transmembrane domain; (e) at least one co-stimulatory domain; and (f) an intracellular signaling domain. The mCARs are activated upon cleavage of the masking peptide.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: November 3, 2020
    Assignee: University of Southern California
    Inventors: Pin Wang, Xiaolu Han, Paul Bryson
  • MASKING CHIMERIC ANTIGEN RECEPTOR T CELLS FOR TUMOR-SPECIFIC ACTIVATION
    Publication number: 20180148508
    Abstract: The invention is directed to a masked chimeric antigen receptor, comprising: (a) a masking peptide; (b) one or more antigen-specific targeting domains; (c) an extracellular spacer domain; (d) a transmembrane domain; (e) at least one co-stimulatory domain; and (f) an intracellular signaling domain. The mCARs are activated upon cleavage of the masking peptide.
    Type: Application
    Filed: June 27, 2016
    Publication date: May 31, 2018
    Applicant: University of Southern California
    Inventors: Pin WANG, Xiaolu HAN, Paul BRYSON