Abstract: The present invention relates to compositions and methods for promoting the degradation of misfolded proteins and protein aggregates. The compositions and methods may be used to treat a disorder associated with misfolded proteins or protein aggregates. In certain instances, the compositions and methods relate to modulators of one or more TRIM proteins or one or more STUbLs.

Abstract: The present invention relates to compositions and methods for promoting the degradation of misfolded proteins and protein aggregates. The compositions and methods may be used to treat a disorder associated with misfolded proteins or protein aggregates. In certain instances, the compositions and methods relate to modulators of one or more TRIM proteins or one or more STUbLs.

Abstract: The present disclosure provides compositions and methods for treating cancer with nutritionally modified diets and/or dialysis treatment, such as through amino acid depletion of one or more nonessential amino acids. In some aspects, the present disclosure provides compositions and methods for treating obesity with such modified diets and/or dialysis treatment. Furthermore, in some aspects, the present disclosure provides compositions and methods for treating renal disease with such modified diets and/or dialysis treatment.

Abstract: The present disclosure provides compositions and methods for treating cancer with nutritionally modified diets and/or dialysis treatment, such as through amino acid depletion of one or more nonessential amino acids. In some aspects, the present disclosure provides compositions and methods for treating obesity with such modified diets and/or dialysis treatment. Furthermore, in some aspects, the present disclosure provides compositions and methods for treating renal disease with such modified diets and/or dialysis treatment.

Abstract: The present disclosure provides compositions and methods for treating cancer with nutritionally modified diets and/or dialysis treatment, such as through amino acid depletion of one or more nonessential amino acids. In some aspects, the present disclosure provides compositions and methods for treating obesity with such modified diets and/or dialysis treatment. Furthermore, in some aspects, the present disclosure provides compositions and methods for treating renal disease with such modified diets and/or dialysis treatment.

Abstract: The present disclosure provides compositions and methods for treating cancer with nutritionally modified diets and/or dialysis treatment, such as through amino acid depletion of one or more nonessential amino acids. In some aspects, the present disclosure provides compositions and methods for treating obesity with such modified diets and/or dialysis treatment. Furthermore, in some aspects, the present disclosure provides compositions and methods for treating renal disease with such modified diets and/or dialysis treatment.

Abstract: The invention discloses a computer system having voice-control function. The computer system includes a voice-recognition module, a shared memory, a microcontroller, a power-management module and a central processing unit. The voice-recognition module receives an external voice signal via a microphone and determines whether the external voice signal corresponds to an operation instruction. The shared memory is used for storing shared state information. The microcontroller is used for setting the shared state information according to the operation instruction when the external voice signal corresponds to the operation instruction. The power-management module generates a power-management signal according to the shared state information in the shared memory. When the power-management module transmits the power-management signal, the central processing unit executes a processing operation corresponding to the operation instruction according to the shared state information in the shared memory.

Abstract: A power management method for use in an electronic system is provided. The electronic system has a processor and a power management unit. The method has the steps of: when the processor has entered a low power state and an awakening event occurs, calculating a staying time from the time point the processor enters the low power state till the time point the awakening event occurs, wherein the operation voltage of the processor is at a first voltage level in the low power state; and when the processing starts to exit the low power state according to the awakening event, determining a wait time, during which the operation voltage of the processor is recovered to a second voltage level of a working state from the first voltage level, wherein the first voltage level is lower than the second voltage level.

Abstract: A power-management method is provided, and the power-management method includes setting a central processing unit in a first low-power state when receiving a second low-power state request requiring the central processing unit to enter the second low-power state, obtaining first idle periods of the peripheral modules respectively to determine a second idle period according to the first idle periods of the peripheral modules, determining whether the peripheral modules have not sent a data-access request during the second idle period, setting the central processing unit in the second low-power state when the peripheral modules have not sent the data-access request during the second idle period, wherein each first idle period is an interval period between two data transmissions of each peripheral module.

Abstract: The invention relates to the discovery that tRNA is a potent regulator of cell survival. tRNA regulates the interaction between cytochrome c and Apaf-1 and subsequently Apaf-1 oligomerization into an apoptosome which in turn recruits and oligomerizes the caspase cascade which ultimately leads to cell death. Accordingly, the present invention provides compositions and methods for regulating cell survival.

Abstract: An integrated circuit for controlling a slave device is provided. The integrated circuit includes a pin, a micro-controller and an inter integrated circuit (I2C) bus controller coupled between the micro-controller and the pin. The I2C bus controller includes a transceiver unit coupled to the slave device via the pin, and an interface unit coupled between the transceiver unit and the micro-controller. The interface unit includes a start control register and a stop control register. The start control register provides a start signal to the slave device via the transceiver unit when the start control register is programmed by the micro-controller. The stop control register provides a stop signal to the slave device via the transceiver unit when the stop control register is programmed by the micro-controller. The micro-controller programs the stop control register according to an interrupt signal from the interface unit.

Abstract: The invention discloses a computer system having voice-control function. The computer system includes a voice-recognition module, a shared memory, a microcontroller, a power-management module and a central processing unit. The voice-recognition module receives an external voice signal via a microphone and determines whether the external voice signal corresponds to an operation instruction. The shared memory is used for storing shared state information. The microcontroller is used for setting the shared state information according to the operation instruction when the external voice signal corresponds to the operation instruction. The power-management module generates a power-management signal according to the shared state information in the shared memory. When the power-management module transmits the power-management signal, the central processing unit executes a processing operation corresponding to the operation instruction according to the shared state information in the shared memory.

Abstract: An integrated circuit for controlling a slave device is provided. The integrated circuit includes a pin, a micro-controller and an inter integrated circuit (I2C) bus controller coupled between the micro-controller and the pin. The I2C bus controller includes a transceiver unit coupled to the slave device via the pin, and an interface unit coupled between the transceiver unit and the micro-controller. The interface unit includes a start control register and a stop control register. The start control register provides a start signal to the slave device via the transceiver unit when the start control register is programmed by the micro-controller. The stop control register provides a stop signal to the slave device via the transceiver unit when the stop control register is programmed by the micro-controller. The micro-controller programs the stop control register according to an interrupt signal from the interface unit.

Abstract: A power-management method is provided, and the power-management method includes setting a central processing unit in a first low-power state when receiving a second low-power state request requiring the central processing unit to enter the second low-power state, obtaining first idle periods of the peripheral modules respectively to determine a second idle period according to the first idle periods of the peripheral modules, determining whether the peripheral modules have not sent a data-access request during the second idle period, setting the central processing unit in the second low-power state when the peripheral modules have not sent the data-access request during the second idle period, wherein each first idle period is an interval period between two data transmissions of each peripheral module.

Abstract: A power management method for use in an electronic system is provided. The electronic system has a processor and a power management unit. The method has the steps of: when the processor has entered a low power state and an awakening event occurs, calculating a staying time from the time point the processor enters the low power state till the time point the awakening event occurs, wherein the operation voltage of the processor is at a first voltage level in the low power state; and when the processing starts to exit the low power state according to the awakening event, determining a wait time, during which the operation voltage of the processor is recovered to a second voltage level of a working state from the first voltage level, wherein the first voltage level is lower than the second voltage level.

Abstract: The invention relates to the discovery that tRNA is a potent regulator of cell survival, tRNA regulates the interaction between cytochrome c and Apaf-1 and subsequently Apaf-1 oligomerization into an apoptosome which in turn recruits and oligomerizes the caspase cascade which ultimately leads to cell death. Accordingly, the present invention provides compositions and methods for regulating cell survival.

Abstract: The present invention relates to a chimeric pro-caspase, which contains a pro-caspase domain and an oligomerizing domain. The invention also relates to an antibody that reacts specifically with a chimeric pro-caspase. In addition, the invention further relates to a polynucleotide encoding a chimeric pro-caspase, and to nucleotide sequences, which can hybridize specifically with a polynucleotide encoding a chimeric pro-caspase. The present invention also relates to a method of inducing apoptosis in a cell by providing a chimeric pro-caspase in the cell, wherein the chimeric pro-caspase includes a pro-caspase domain and an oligomerizing domain, whereby the chimeric pro-caspase forms an oligomer in the cell, thereby activating caspase activity of the chimeric pro-caspase and inducing apoptosis in the cell.

Abstract: The present invention relates to a chimeric pro-caspase, which contains a pro-caspase domain and an oligomerizing domain. The invention also relates to an antibody that reacts specifically with a chimeric pro-caspase. In addition, the invention further relates to a polynucleotide encoding a chimeric pro-caspase, and to nucleotide sequences, which can hybridize specifically with a polynucleotide encoding a chimeric pro-caspase. The present invention also relates to a method of inducing apoptosis in a cell by providing a chimeric pro-caspase in the cell, wherein the chimeric pro-caspase includes a pro-caspase domain and an oligomerizing domain, whereby the chimeric pro-caspase forms an oligomer in the cell, thereby activating caspase activity of the chimeric pro-caspase and inducing apoptosis in the cell.

Abstract: The invention describes nucleic acids encoding the Daxx protein, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such nucleic acids, and antibodies relating thereto. Methods and products for using such nucleic acids and polypeptides also are provided.