Abstract: The present invention relates to a compound having the general formula (1) wherein in the general formula (1) the residues R1 to R8 and Ar are the same or different and are independently from each other selected from the group consisting of hydrogen, unsubstituted hydrocarbon groups, substituted hydrocarbon groups and inorganic groups, wherein at least one of the residues R1 to R8 and Ar is a hydrophilic group, such as for instance a group comprising one or more polyethylene groups.

Abstract: An on-chip adaptive optical receiver system, an optical chip, and a communication device are disclosed, which are applied to optical communication. The on-chip adaptive optical receiver system includes an antenna array configured for separating received spatial light to obtain a plurality of sub-light spots; an optical phased array configured for performing phase-shifting processing and beam combining processing on the sub-light spots to obtain combined light; and an optical receiving module configured for demultiplexing the combined light to obtain beacon light. The optical receiving module is further configured for detecting intensity information of the beacon light and generating a feedback signal according to the intensity information.

Abstract: A display substrate and a display device. The display substrate includes a base, an insulating layer, a crack barrier structure, and a signal line. The crack barrier structure is located in a peripheral area, and at least a part of an orthographic projection of the crack barrier structure onto the base extends in an extension direction of a boundary of a display area. The crack barrier structure includes: a groove structure and a blocking portion, the groove structure is in the insulating layer, and a part of the blocking portion is located in the groove structure. The signal line is located at the peripheral area, and includes a top surface facing away from the base, and a side surface located between the top surface and the base, and at least a part of the side surface away from the display area is between the blocking portion and the groove structure.

Abstract: The present invention provides a tiering device for a freight compartment, which pertains to the technical field of logistic and transportation equipment. It solves the problem in the prior art that existing tiering devices for a freight compartment occupy a relatively large space inside the freight compartment. The tiering device for a freight compartment according to the present invention comprises: a sidewall of the freight compartment, a transmission part, and a vertical guide track; the transmission part lift/lower support members, the support members forms placement area for goods. Half of the transmission part is buried inside a belt guide channel on the vertical guide track, the other half is located inside the vertical guide track or is flush with the groove opening of the vertical guide track. The present invention occupies less space inside the freight compartment, thus facilitating loading/unloading goods to/from the freight compartment.

Abstract: This application discloses a fault protection method, including: A first node determines that a first cross-domain node is faulty. The first node is a head node of a segment routing best effort SR-BE service tunnel, the SR-BE tunnel is a cross-domain tunnel that passes through a first IGP domain and a second IGP domain, the SR-BE tunnel passes through the first cross-domain node, and the first cross-domain node is a node that crosses the first IGP domain and the second IGP domain. The first node switches a service transmission path from the SR-BE tunnel to a backup tunnel. The backup tunnel does not pass through the first cross-domain node, and the backup tunnel is a tunnel with a strict explicit path.

Abstract: A vehicle airflow system includes a centrifugal fan and an air diffuser. The centrifugal fan is configured to direct air radially outward from a rotational axis of the fan. The air diffuser has a plurality of air deflectors that are disposed radially about the fan. The air deflectors have curved surfaces. Each curved surface defines an airflow channel that has an inlet extending radially outward from a periphery of the centrifugal fan and an outlet extending axially away from the diffuser relative to the rotational axis of the fan.

Abstract: A header tank of a heat exchanger. The header tank includes a housing defining a coolant chamber through which coolant flows. The header tank further includes a flow control member, which extends into the coolant chamber. The flow control member is configured to advantageously reduce swirling of coolant in the coolant chamber, reduce velocity of coolant in the coolant chamber, and reduce liquid pressure drop of the heat exchanger.

Abstract: A message transmission method is provided. A processor that implements a first client, corresponding to a first account, determines a second account which performs message interaction with the first account, the second account corresponding to a second client. The first client transmits to the second client a preset link that is usable for playing a target media file at the second client, the target media file being currently played at the first client. The first client transmits and receives a message between the first account and the second account based on the target media file being played at the first client and the second client, the message being displayed on a first preset page of the first client.

Abstract: A vehicle airflow system includes a centrifugal fan and an air diffuser. The centrifugal fan is configured to direct air radially outward from a rotational axis of the fan. The air diffuser has a plurality of air deflectors that are disposed radially about the fan. The air deflectors have curved surfaces. Each curved surface defines an airflow channel that has an inlet extending radially outward from a periphery of the centrifugal fan and an outlet extending axially away from the diffuser relative to the rotational axis of the fan.

Abstract: A header tank of a heat exchanger. The header tank includes a housing defining a coolant chamber through which coolant flows. The header tank further includes a flow control member, which extends into the coolant chamber. The flow control member is configured to advantageously reduce swirling of coolant in the coolant chamber, reduce velocity of coolant in the coolant chamber, and reduce liquid pressure drop of the heat exchanger.

Abstract: A message transmission method is provided. A processor that implements a first client, corresponding to a first account, determines a second account which performs message interaction with the first account, the second account corresponding to a second client. The first client transmits to the second client a preset link that is usable for playing a target media file at the second client, the target media file being currently played at the first client. The first client transmits and receives a message between the first account and the second account based on the target media file being played at the first client and the second client, the message being displayed on a first preset page of the first client.

Abstract: A double-chambered infusion bag includes a sealed soft infusion bag, a first chamber and a second chamber separated by a first peelable strip pseudo soldering structure are formed inside the sealed soft infusion bag. A second peelable strip pseudo soldering structure is provided between the second chamber and an output tube. A breakthrough pressure of the second peelable strip pseudo soldering structure is equal to or greater than a breakthrough pressure of the first peelable strip pseudo soldering structure. A periphery of the second chamber is permanently connected with compound aluminum films or transparent or semi-transparent compound films.

Abstract: Various embodiments provide systems and methods enable a user to receive feedback regarding a computer-implemented design of an architectural structure as the user is designing or otherwise modifying the computer-implemented design using a computer-aided design (CAD) software tool. The feedback (hereafter also referred to as “design feedback”) may provide the user with useful analysis information regarding the architectural structure's predicted characteristics (e.g., operational performance, resource consumption, cost, etc.) based on the current state of the computer-implemented design. As the user performs one or more actions on the computer-implemented design model (e.g., through the CAD software tool), particularly with respect to the geometry or texture of the computer-implemented design model, systems and methods can provide the impact of those actions, possibly at or near the time the actions were executed (e.g., at or near real-time).

Abstract: Compounds which inhibit the activity of signal transducer and activator of transcription 3 (STAT3) are provided together with methods of making and using the same. The compounds are designed to bind to the SH2 domain of STAT3, preventing STAT3 from binding to receptors for interleukin-6 family cytokines, growth factors such as the platelet-derived growth factor, the epidermal growth factor, vascular endothelial growth factor, and other signaling molecules such as leptin. Blocking these interactions prevents STAT3 from being phosphorylated on Tyr705, which is required for the dimerization of STAT3, translocation to the nucleus, binding to STAT3 response elements on promotors, and transcription of genes. In addition to these activities, binding to the SH2 domain of STAT3 breaks up pre-formed dimmers, thereby preventing the transcriptional activity of the inhibitor.

Abstract: Compounds which inhibit the activity of signal transducer and activator of transcription 3 (STAT3) are provided together with methods of making and using the same. The compounds are designed to bind to the SH2 domain of STAT3, preventing STAT3 from binding to receptors for interleukin-6 family cytokines, growth factors such as the platelet-derived growth factor, the epidermal growth factor, vascular endothelial growth factor, and other signaling molecules such as leptin. Blocking these interactions prevents STAT3 from being phosphorylated on Tyr705, which is required for the dimerization of STAT3, translocation to the nucleus, binding to STAT3 response elements on promotors, and transcription of genes. In addition to these activities, binding to the SH2 domain of STAT3 breaks up pre-formed dimmers, thereby preventing the transcriptional activity of the inhibitor.

Abstract: Stat3 inhibitor compounds are disclosed, wherein the compounds are structural analogs of Ac-pTyr-Leu-Pro-Gln-Thr-NH2 and bind to the SH2 domain of Stat3 under physiological conditions to inhibit a cellular signaling activity of Stat3.

Abstract: The invention identifies an interface domain for interaction between two or more dimers of Signal Transducer and Activator of Transcription (STAT) proteins formed between amino acid residues Gln8 (Q8), Ile12 (I12), and Leu15 (L15) of &agr; helices 1 and 2, Met28 (M28) and Glu29 (E29) of &agr; helix 3 of a first STAT protein partner of the dimer, and Leu77 (L77) and Leu78 (L78) in &agr; helix 7 of a second STAT protein partner of the dimer. The interface domain is useful for designing and identifying compounds capable of enhancing or inhibiting binding between STAT protein dimers and/or DNA binding sites, and thus useful for identifying compounds able to modulate STAT protein dimer-dimer induction of gene expression.

Abstract: The present invention provides a crystal of the core portion of the STAT protein in dimeric form with an 18-mer duplex DNA that contains a binding site for the STAT-dimer. The crystal is of sufficient quality to perform X-ray crystallographic studies. Methods of preparing the crystals are include in the invention. The present invention further discloses the three-dimensional structure of the crystal. The present invention also provides methods of using the structural information in drug discovery and drug development.