Abstract: A direct well-tie method for depth-domain logging and seismic data, including: removing null and outlier values from logging velocity data and logging density data to obtain valid logging velocity data and valid logging density data; calculating a logging reflection coefficient; estimating an initial zero-phase depth-domain seismic wavelet from seismic section; making a depth-domain synthetic seismogram; interpolating the depth-domain seismogram at the logging location; performing cross-correlating operation between the depth-domain synthetic seismogram and the interpolated depth-domain seismogram at the logging location; estimating a depth-domain seismic wavelet; updating the depth-domain synthetic seismogram; generating a corresponding depth deviation point set; subjecting elements in the set to interpolation to obtain a depth calibration curve; subjecting the depth calibration curve and depth axis to addition to obtain depth axis; generating a logging depth-seismic depth corresponding relationship and a de

Abstract: Prodrugs that target the low-density lipoprotein receptor (LDLR) and that comprise acid and/or enzyme cleavable acetal- or oxybenzyloxy-linked carbonate or carbamate bonds are described. Also described are core-shell nanoparticles comprising metal-organic framework cores or nanoscale metal bisphosphate coordination polymer cores, and lipid coating layers containing the prodrugs. The nanoparticle core can optionally contain one or more hydrophilic chemotherapeutic agents. The prodrugs and nanoparticles can be used in methods of treating cancer. For instance, the presently disclosed nanoparticles can be used for the co-delivery of multiple chemotherapeutic agents in methods providing increased accumulation of chemotherapeutic agents to a tumor compared to delivery of mixtures of free chemotherapeutic agents.

Abstract: A direct well-tie method for depth-domain logging and seismic data, including: removing null and outlier values from logging velocity data and logging density data to obtain valid logging velocity data and valid logging density data; calculating a logging reflection coefficient; estimating an initial zero-phase depth-domain seismic wavelet from seismic section; making a depth-domain synthetic seismogram; interpolating the depth-domain seismogram at the logging location; performing cross-correlating operation between the depth-domain synthetic seismogram and the interpolated depth-domain seismogram at the logging location; estimating a depth-domain seismic wavelet; updating the depth-domain synthetic seismogram; generating a corresponding depth deviation point set; subjecting elements in the set to interpolation to obtain a depth calibration curve; subjecting the depth calibration curve and depth axis to addition to obtain depth axis; generating a logging depth-seismic depth corresponding relationship and a de