Abstract: A pyridine derivative and use thereof are provided. The compound has an obvious inhibitory effect on the activity of KRAS and PI3K proteins, can be used as a KRAS and/or PI3K protein inhibitor, and can be used for preparing a drug for treatment of diseases such as KRAS or PI3K protein-mediated cancer. The compound has an extremely strong inhibitory effect on a KRAS G12C inhibitor (e.g. AMG-510) drug-resistant cancer cells, and has a wide application prospect thereof.

Abstract: A machining and positioning system for aerospace irregular parts and a discrete intelligent production line therefor are provided, which relates to the field of aerospace irregular part machining. In view of the problem that complex repeated positioning and poor positioning stability is required during the transportation and processing of aerospace irregular parts, a self-positioning device, a clamping device, and a support device are used to form a follow-up clamping and positioning system for the irregular part casing, reducing complex repeated positioning. The support block of the support device can fit to the inner wall of the casing, collect the support force using piezoelectric plates, and feedback and adjust the thrust of the support block based on the magnitude of the cutting radial force, maintaining stable support of the support block for the casing and meeting production needs.

Abstract: Novel tools and techniques are provided for implementing a semiconductor package or a chip package, and more particularly methods, systems, and apparatuses are provided for implementing a semiconductor package or a chip package including a backside power distribution network. In various embodiments, an apparatus includes a first substrate comprising a device configured to receive a voltage and a first side located on a front side of the first substrate and a second side located on a back side of the first substrate, a second substrate, the second substrate configured to support the first substrate, and a power distribution network located at an interface between the second side of the first substrate and the second substrate.

Abstract: A rolling bearing combined fault diagnosis method based on a multi-domain feature construction is provided, including: collecting vibration signals of rolling bearings, extracting time-domain and frequency-domain features of fault-sensitive vibration signals of the rolling bearings, and obtaining an in-domain feature set; performing an improved empirical mode decomposition on the vibration signals of the rolling bearings to obtain time-frequency features; constructing a multi-domain fault sample set based on the in-domain feature set and the time-frequency features; performing a fault mechanism analysis on the multi-domain fault sample set to obtain modulation features under each single fault; carrying out a feature engineering on the time-domain and frequency-domain features, and screening out relevant features, redundant features and irrelevant features; performing an unsupervised hierarchical clustering on test set fault samples, and then inputting the test set fault samples into a KNN model for a classifi

Abstract: A method and system for rapid retrieval of target images based on artificial intelligence, obtaining a template image and a plurality of known labels corresponding to the template image; extracting an image to be detected from a target image database; inputting both the image to be detected and the template image into a trained convolutional neural network, and outputting a hash code of the image to be detected and a hash code of the template image; obtaining a similarity between the images based on a Hamming distance between the hash codes, then selecting one or more images to be detected with the similarity higher than a set threshold as a retrieval result to output. Accordingly, the method and system is able to better cope with the retrieval of items in complex scenarios.

Abstract: Embodiments described herein relate to electrochemical cells with dendrite prevention mechanisms. In some aspects, an electrochemical cell can include an anode disposed on an anode current collector, a cathode disposed on a cathode current collector, the cathode having a first thickness at a proximal end of the cathode and a second thickness at a distal end of the cathode, the second thickness greater than the first thickness, a first separator disposed on the anode, a second separator disposed on the cathode, an interlayer disposed between the first separator and the second separator, the interlayer including electroactive material and having a proximal end and a distal end, and a power source electrically connected to the proximal end of the cathode and the proximal end of the interlayer, the power source configured to maintain a voltage difference between the cathode and the interlayer below a threshold value.

Abstract: Disclosed are a lithium aluminum hydrotalcite-based solid electrolyte film, a preparation method and use thereof, and a lithium battery including the same. The lithium aluminum hydrotalcite-based solid electrolyte film includes: a solid electrolyte film substrate formed by an organic polymer, and a lithium salt and a lithium aluminum hydrotalcite uniformly dispersed in the solid electrolyte film substrate, wherein the lithium aluminum hydrotalcite has a content of 50 wt % to 80 wt %, based on a total mass of the solid electrolyte film substrate after removal of the lithium salt; and the organic polymer includes one or more selected from the group consisting of polyethylene glycol diacrylate, polyethylene oxide, polypropylene carbonate, and polyvinylidene fluoride-hexafluoropropylene copolymer.

Abstract: The use of Black Solider Fly Larvae as Palatant/Palatability Enhancer for use in edible pet products This invention disclosed a palatability enhancer for edible pet products using black solider fly (Hermetia illucens) larvae, wherein the black solider fly larvae are collected following the commercial farming, the greater part of the materials being processed for safety and size reduced as necessary, at 10.0%-80.0%. The palatability enhancer may also include at least one of the following: Cysteine, Arginine, Alanine, Glutamine, Aspartic acid, Glycine, Phenylalanine, Isoleucine, Histidine, Vitamin B1, and a reducing sugar, at 0.1%-10.0% by weight.

Abstract: This disclosure provides data processing methods, apparatuses, and systems. In an implementation, a method comprises receiving, by a first data processing unit (DPU), a memory allocation request from a first service process in a computing node that comprises the first DPU, wherein the first DPU stores memory address assignment information that indicates a virtual memory address corresponding to a physical memory allocated by a storage node to the computing node. Determining, by the first DPU based on the memory address assignment information and in the virtual memory address corresponding to the physical memory allocated by the storage node to the computing node, a virtual memory address range assigned to the first service process, and when the first DPU receives a data storage request from the first service process, sending, by the first DPU, a write data request to the second DPU over a communication link between the first DPU and the second DPU.

Abstract: Provided are an information generation method and apparatus, and an electronic device.

Abstract: Semiconductor device structures and methods for manufacturing the same are provided. The semiconductor device structure includes a substrate, a first nitride semiconductor layer, a second nitride semiconductor layer, a first transistor and a clamping device. The first nitride semiconductor layer is disposed on the substrate. The second nitride semiconductor layer is disposed on the first nitride semiconductor layer. The first transistor is disposed on the second nitride semiconductor layer. The first transistor includes a first control electrode, a first current electrode and a second current electrode. The clamping device is disposed on the second nitride semiconductor layer and electrically coupled with the first transistor. The clamping device includes a second transistor and a third transistor electrically coupled with the second transistor. The clamping device is electrically coupled with the first current electrode and the second current electrode of the first transistor.

Abstract: The present disclosure relates to a communication method, system, base station, and terminal. The method includes: sending, by a first BS, a broadcast message, which comprises: a NID and a PLMN ID, which correspond to each of one or more SNPNs supported by the first BS; receiving, by the first BS, a connection request sent from a terminal, wherein the connection request represents that the first BS supports at least one of one or more SNPNs subscribed by the terminal; establishing, by the first BS, a RRC connection with the terminal; receiving, by the first BS, a RRC connection setup complete message sent from the terminal, wherein the RRC connection setup complete message carries a NID and a PLMN ID, which correspond to a SNPN that the terminal selects to access; and connecting, by the first BS, the terminal to the SNPN that the terminal selects to access.

Abstract: This application discloses a memory circuit. Each row of cells includes M+1 bit cells. First to Mth bit cells normally store M-bit data; an (M+1) th bit cell stores opposite data of an ith bit cell; each row of sense amplifiers includes M sense amplifiers; one positive input end of an ith sense amplifier is connected with an output end of the ith bit cell; one negative input end of the ith sense amplifier is connected with an output end of the (M+1) th bit cell; two positive input ends of a jth sense amplifier are connected with an output end of a jth bit cell; two negative input ends of the jth sense amplifier are respectively connected with an output end of the (M+1) th bit cell and an output end of the ith bit cell. The memory circuit can improve data retention and increase the utilization rate of the cells.

Abstract: Disclosed is an in-situ detection robot for loess geological information, including a housing, an active tensioning system, an auxiliary tensioning system, a control system, a drive system, and a detection system. The active tensioning system is configured to provide the robot with a tensioning force in an aperture direction of a loess hole for the robot to travel in the loess hole. The auxiliary tensioning system is configured to provide the robot with a pre-tensioning force for the robot to travel in the loess hole. The control system is configured to control a movement mode of the robot according to different travelling environments of the robot in the loess hole. The driving system is configured to provide the robot with a travelling power in the loess hole. The detection system is configured to detect related parameters of the loess geological information.

Abstract: A lighting apparatus includes a first light source, a second light source and a driver. The first light source has multiple first LED modules. The second light source has multiple second LED modules. The driver controls the first light source and the second light source to generate an output light of a required mixed color temperature. The driver selects a first subset of the multiple first LED modules and a second subset of the multiple second LED modules to generate a first output light with a first color temperature. The driver selects a third subset of the multiple first LED modules and a fourth subset of the multiple second LED modules to generate a second output light with a second color temperature. The first subset is not equal to the third subset. The second subset is not equal to the fourth subset.

Abstract: Described are a carbon-iodine conjugated polymer and preparation thereof, an imaging marker thereof, and uses thereof for preparing a localization marker, and belongs to the technical field of imaging markers. The conjugated structure enables the polymer to have strong absorption in a visible light region, and high iodine content of up to 84.1% corresponds to the strong imaging ability thereof. During surgery, on the basis of the dual guidance of a polymer-based image marker and naked eye observation, the marker can better facilitate determination of tumor resection margins, achieving precise resection of tumors and minimizing damage to surrounding normal tissues. During cyberknife-based treatment, the polymer can replace clinical gold markers to provide ray marker guidance.

Abstract: Equipment for self-positioning handling of aluminum profiles for rail vehicle, including a handling and lifting mechanism, a steel beam fixed on and being driven to lift by the mechanism, 2-DOF spatial mechanisms fixed on the steel beam and mechanical clamping jaws fixed on a clamping jaw connecting seat; the 2-DOF spatial mechanisms includes a cylinder supporting seat, four connecting members on an outer ring of the cylinder supporting seat hinged respectively to four first connecting rods; wherein, two of the first rods are hinged to first ends of two ball joint connecting rods of which second ends are hinged to the clamping jaw connecting seat; the other two first rods are hinged to first ends of two second connecting rods of which second ends are hinged to the clamping jaw connecting seat; a piston rod of a cylinder center of the cylinder supporting seat driving the clamping jaw connecting seat.

Abstract: An intelligent separation method of peanut kernel and red coat, feeding peanuts to be removed red coats into a device for a gas explosion of the red coats of the peanuts, to complete a preliminary separation of kernels and the red coats of the peanuts; feeding the primarily separated kernels and peanut red coats of the peanuts into the drying device to fully separate the red coats from the kernels; delivering the fully separated peanut kernels and red coats of the peanuts into a negative pressure adsorption device to collect respectively the fully separated kernels and red coats of the peanuts with different densities and qualities by a negative pressure adsorption mode, finally obtaining the kernels of the peanuts without the red coats, and the red coats of the peanuts respectively.

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

Abstract: Embodiments of the present disclosure provide methods and apparatuses for failure recovery. A method performed by a mobility management entity, comprising determining a failure occurs at a first session management entity. The method further comprises sending a first message to a terminal device, wherein the first message includes a Protocol Data Unit, PDU, session status information indicating that the first session management entity related PDU session is inactive.