Abstract: The present invention relates to a compound of chemical Formula (I), a preparation method therefor, and an application thereof, as well as a pharmaceutical composition comprising the compound as an active ingredient, or a pharmaceutically acceptable salt thereof. The present invention further relates to a use of the compound of Formula (I) in the treatment and prevention of EP4-mediated diseases.

Abstract: The present invention belongs to the field of pharmaceutical manufacturing technology. The present invention provides a pharmaceutical composition of a conjugate and a preparation method thereof. The pharmaceutical composition is preferably administered by injection. The docetaxel conjugate has a structural formula as shown in the following formula: (I).

Abstract: The present disclosure relates to a heterocyclic amide derivative, a preparation method therefor and an application thereof. Specifically, the present disclosure relates to a compound of formula I, a preparation method therefor and an application thereof, a pharmaceutical composition containing the compound as an active ingredient, or a pharmaceutically acceptable salt thereof. The present disclosure further relates to a use of the compound of formula (I) in the treatment and prevention of EP4-mediated diseases.

Abstract: Disclosed are a pyrazolo[1,5-a]pyridine compound, a preparation method therefor and a use thereof. Also disclosed is a pharmaceutical composition containing the compound as an active ingredient or a pharmaceutically acceptable salt thereof. The present invention further relates to the use of a compound of formula (I) for treating and preventing diseases that can be treated with wild-type, gene fusion-type and mutant (including but not limited to G804 and G810) RET kinase inhibitors, including diseases or conditions mediated by an RET kinase.

Abstract: The present invention relates to a pyrazolo[1,5-a]pyridine derivative, a preparation method therefor, and a composition and a use thereof. Specifically, the present invention relates to the compound of formula (I) and the use thereof for the treatment and/or prevention of wild type, gene-fusion type (including but not limited to KIF5B, CCDC6 and NCOA4) and mutant type (including but not limited to V804, G810 and M918) RET kinases-related diseases, including diseases or conditions mediated by RET kinase.

Abstract: The present invention belongs to the field of pharmaceutical manufacturing technology. The present invention provides a pharmaceutical composition of a conjugate and a preparation method thereof. The pharmaceutical composition is preferably administered by injection. The docetaxel conjugate has a structural formula as shown in the following formula: (I).

Abstract: Solvent absorption processes for separating components of an impure feed gas are disclosed. The processes involve two stages of gas purification. The acid gases including hydrogen sulfide, carbon dioxide and other sulfur compounds are simultaneously removed from the feed gas by contact with a physical solvent in two stages. The subject matter disclosed provides improved processes to reduce the operating costs of the system.

Abstract: Separation processes and separation apparatus are described. The process includes introducing a stream of liquid containing dispersed droplets of another liquid into a separation apparatus comprising a vessel having at least one mesh screen covering substantially all of the cross-section of the vessel. The mesh screen is periodically slightly moved so that the wires of the mesh screen contact the dispersed droplets and some of the dispersed droplets coalesce on the wires. The coalesced droplets rise or fall from the wires through the stream of the second liquid. The coalesced droplets are collected in a portion of the vessel. A stream of the second liquid having a reduced level of dispersed droplets is recovered.

Abstract: A boiler ash remover based on a combined flow includes a frequency-adjustable acoustic flow generator, a fixing bracket, a compressed air source, a three-way air-source electric-control valve, an air jet generator, an acoustic-jet combined transmission tube, an acoustic jet intelligent control system, and a scale measurement and control sensor. The compressed air source is connected to an inlet end of the three-way air-source electric-control valve. An outlet end of the three-way air-source electric-control valve is connected to the frequency-adjustable acoustic flow generator and an air source inlet end of the air jet generator respectively. An acoustic flow outlet end of the frequency-adjustable acoustic flow generator is connected to an inlet end of the acoustic-jet combined transmission tube. An outlet end of the acoustic-jet combined transmission tube and a jet outlet end of the air jet generator are both disposed opposite to an external heat exchange component by means of the fixing bracket.

Abstract: Solvent absorption processes for separating components of an impure feed gas are disclosed. The processes involve two stages of gas purification. The acid gases including hydrogen sulfide, carbon dioxide and other sulfur compounds are simultaneously removed from the feed gas by contact with a physical solvent in two stages. The subject matter disclosed provides improved processes to reduce the operating costs of the system.

Abstract: Solvent absorption processes for separating components of an impure feed gas are disclosed. The processes involve two stages of gas purification. The acid gases including hydrogen sulfide, carbon dioxide and other sulfur compounds are simultaneously removed from the feed gas by contact with a physical solvent in two stages. The subject matter disclosed provide improved processes and apparatus to reduce the operating costs of the system.

Abstract: Disclosed is a sound absorption plate with a unit structure. The sound absorption plate comprises an ultramicropore sound absorption front plate (1), a side plate (2) and a sound absorption back plate (3). Edge parts of the ultramicropore sound absorption front plate (1) are connected to the sound absorption back plate (3) through the side plate (2), thereby forming a sound absorption resonant cavity (4). The material of the ultramicropore sound absorption front plate (1) is a metal material carrying nano microspheres (5). A sound absorption metal thin film (6) carrying nano microspheres (5), parallel to the ultramicropore sound absorption front plate, is disposed inside the sound absorption resonant cavity (4). A pore size of the nano microspheres in the ultramicropore sound absorption front plate (1) and the sound absorption metal thin film (6) is 100-1000 nm.

Abstract: A boiler ash remover based on a combined flow includes a frequency-adjustable acoustic flow generator, a fixing bracket, a compressed air source, a three-way air-source electric-control valve, an air jet generator, an acoustic-jet combined transmission tube, an acoustic jet intelligent control system, and a scale measurement and control sensor. The compressed air source is connected to an inlet end of the three-way air-source electric-control valve. An outlet end of the three-way air-source electric-control valve is connected to the frequency-adjustable acoustic flow generator and an air source inlet end of the air jet generator respectively. An acoustic flow outlet end of the frequency-adjustable acoustic flow generator is connected to an inlet end of the acoustic-jet combined transmission tube. An outlet end of the acoustic-jet combined transmission tube and a jet outlet end of the air jet generator are both disposed opposite to an external heat exchange component by means of the fixing bracket.

Abstract: Disclosed is a sound absorption plate with a unit structure. The sound absorption plate comprises an ultramicropore sound absorption front plate (1), a side plate (2) and a sound absorption back plate (3). Edge parts of the ultramicropore sound absorption front plate (1) are connected to the sound absorption back plate (3) through the side plate (2), thereby forming a sound absorption resonant cavity (4). The material of the ultramicropore sound absorption front plate (1) is a metal material carrying nano microspheres (5). A sound absorption metal thin film (6) carrying nano microspheres (5), parallel to the ultramicropore sound absorption front plate, is disposed inside the sound absorption resonant cavity (4). A pore size of the nano microspheres in the ultramicropore sound absorption front plate (1) and the sound absorption metal thin film (6) is 100-1000 nm.

Abstract: Vapor-liquid contacting apparatuses and methods for removing contaminants from gas streams are provided. In an embodiment, a vapor-liquid contacting apparatus includes a vortex contacting stage having a contacting zone bound by a wall and defining an axis, a radially inner region surrounding the axis, and a radially outer region adjacent the wall. The vapor-liquid contacting apparatus also includes a feed conduit configured to direct flow of a feed gas into the radially outer region of the contacting zone in a direction tangential to the axis to form a vortex. Further, the vapor-liquid contacting apparatus includes a liquid conduit configured to deliver a liquid absorbent stream to the radially inner region in the contacting zone.

Abstract: A low pressure re-absorber is integrated with a sulfur-rich solvent flash drum or a sulfur-rich solvent stripping column in a solvent acid gas removal process that provides for sufficient sulfur concentration for the downstream sulfur recovery unit. In another aspect of the invention, carbon dioxide containing or carbon dioxide rich gas streams that are at a lower temperature relative to a lean solvent stream are used to cool those lean solvent streams and then optionally to cool other process streams, to save energy consumption.

Abstract: Separation processes and separation apparatus are described. The process includes introducing a stream of liquid containing dispersed droplets of another liquid into a separation apparatus comprising a vessel having at least one mesh screen covering substantially all of the cross-section of the vessel. The mesh screen is periodically slightly moved so that the wires of the mesh screen contact the dispersed droplets and some of the dispersed droplets coalesce on the wires. The coalesced droplets rise or fall from the wires through the stream of the second liquid. The coalesced droplets are collected in a portion of the vessel. A stream of the second liquid having a reduced level of dispersed droplets is recovered.

Abstract: A low pressure re-absorber is integrated with a sulfur-rich solvent flash drum or a sulfur-rich solvent stripping column in a solvent acid gas removal process that provides for sufficient sulfur concentration for the downstream sulfur recovery unit. In another aspect of the invention, carbon dioxide containing or carbon dioxide rich gas streams that are at a lower temperature relative to a lean solvent stream are used to cool those lean solvent streams and then optionally to cool other process streams, to save energy consumption.

Abstract: Vapor-liquid contacting apparatuses and methods for removing contaminants from gas streams are provided. In an embodiment, a vapor-liquid contacting apparatus includes a vortex contacting stage having a contacting zone bound by a wall and defining an axis, a radially inner region surrounding the axis, and a radially outer region adjacent the wall. The vapor-liquid contacting apparatus also includes a feed conduit configured to direct flow of a feed gas into the radially outer region of the contacting zone in a direction tangential to the axis to form a vortex. Further, the vapor-liquid contacting apparatus includes a liquid conduit configured to deliver a liquid absorbent stream to the radially inner region in the contacting zone.

Abstract: The present invention provides a membrane/amine column system and process for removing acid gases from natural gas on a floating liquefied natural gas vessel. Several process configurations are provided to deal with a reduction in the effectiveness of the amine column by increasing the amount of acid gases being removed by the membrane system prior to the natural gas being sent to the amine column.