Patents by Inventor Xiaonan Yang

Xiaonan Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250186598
    Abstract: Provided is a recombinant human serum albumin-collagen binding domain (CBD) fusion protein for tumor-specific targeting matrix and its use in specific targeted treatment of a solid tumor. HSA and the CBD generate gene fusion in the form of different molecular structures, and can be expressed in a constructed recombinant engineered host. A pharmaceutical recombinant fusion protein is obtained through large-scale fermentation. The recombinant fusion protein shows tumor-specific targeting of solid tumors and can be used as a starting material of a broad-spectrum matrix carrier. The recombinant fusion protein is coupled with any tumor treatment drug, small-molecule compound, or cytotoxic protein to form an innovative pharmaceutical composition. The pharmaceutical composition of the recombinant fusion protein is also long-acting, can prolong a half-life of the conjugate drug in vivo, and has a significantly better clinical curative efficacy on anti-tumor than that of a monomer drug.
    Type: Application
    Filed: November 13, 2020
    Publication date: June 12, 2025
    Inventors: Yan FU, Dianxin LIU, Xiaonan YANG, Yusong FU, Fang HAN, Jingsheng YANG, Ying CHEN
  • Publication number: 20240156917
    Abstract: The present invention belongs to the technical field of biomedical formulations. Provided are a temperature sensitive gel damage repair formulation and an application thereof. The formulation includes 0.01-5 mg/mL rHSA/EGF, 1.9-2.6% m/m glycine, 3.9-6.2% m/m poloxamer 188, 16.3-18.2% m/m poloxamer 407, and 0.5-100 mM phosphate buffer.
    Type: Application
    Filed: July 20, 2021
    Publication date: May 16, 2024
    Inventors: Yan Fu, Dianxin Liu, Xiaonan Yang, Yusong Fu, Fang Han, Liguang Song, Jingsheng Yang, Ying Chen
  • Publication number: 20240075105
    Abstract: Provided is a fusion protein of human serum albumin or a wild type thereof and human interleukin-2 or a mutation thereof, said fusion protein has a significantly extended in vivo half-life relative to recombinant interleukin-2, can be used alone for treating a tumor, and improves anti-tumor efficacy of an anti-PD-1 antibody or an anti PD-L1-antibody.
    Type: Application
    Filed: November 15, 2021
    Publication date: March 7, 2024
    Inventors: Zailin Yu, Yan Fu, Xiaonan Yang, Yusong Fu, Guoqiang Qiao, Qiong Hou, Tao Zhu
  • Patent number: 6395680
    Abstract: A composition includes at least two aromatic carboxylic acid compounds selected from the group consisting of aromatic carboxylic acid compounds of formulas (I), (II) and (III) as specified in the specification. A thermosensitive recording material has a support, and a thermosensitive coloring layer formed thereon which contains a leuco dye and a color developer capable of inducing color formation in the leuco dye upon application of heat thereto, with the color developer comprising the aforementioned composition of the aromatic carboxylic acid compounds.
    Type: Grant
    Filed: April 12, 2000
    Date of Patent: May 28, 2002
    Assignees: Ricoh Company, Ltd., Nicca Chemical Co., Ltd.
    Inventors: Mitsunobu Morita, Kunio Hayakawa, Ikuo Kameoka, Xiaonan Yang