Abstract: The present disclosure provides use of Clostridium ghonii combined with a tumor angiogenesis inhibitor in preparing a pharmaceutical product for treating a tumor. The present disclosure further provides a drug for treating a tumor, where the drug includes active ingredients of Clostridium ghonii and a tumor angiogenesis inhibitor.

Abstract: The present disclosure relates to use of a Clostridium ghonii spore combined with pembrolizumab in cancer treatment. It is found for the first time that the Clostridium ghonii spore combined with pembrolizumab can significantly improve a curative effect of colon cancer and reduce a dose of the pembrolizumab, and thus is efficient and low-toxic. Oncolysis by Clostridium ghonii can affect immunogenicity of a tumor microenvironment (TME) by various ways, converts an immunosuppressive state of the TME into an immune-activated state, adjusts the immunosuppressive TME, and breaks an immune tolerance. An optimal combination of the Clostridium ghonii spore and the pembrolizumab thoroughly removes about 20% of mouse tumor tissues. A benefit range of patients with tumors treated by a PD-1 antibody is expanded. The combination even has an obvious curative effect on patients failed the treatment by the PD-1 antibody.

Abstract: Provided is a fusion protein of human serum albumin or a wild type thereof and human interleukin-2 or a mutation thereof, said fusion protein has a significantly extended in vivo half-life relative to recombinant interleukin-2, can be used alone for treating a tumor, and improves anti-tumor efficacy of an anti-PD-1 antibody or an anti PD-L1-antibody.

Abstract: The present disclosure refers to a method for preparing sintered NdFeB magnets, including: a) Preparing alloy flakes from a raw material by strip casting, performing a hydrogen decrepitation to produce alloy pieces, pulverization the alloy pieces to an alloy powder, performing molding and orientation, cold isostatic pressing, and getting a green compact; b) Putting the green compact into a vacuum furnace and performing a first sintering step in 830 to 880° C. for 2 to 10 hours and 5×10?1 Pa or less; c) Performing a second sintering step while applying a pressure to the green compact achieved by step b), the pressure is 1 MPa to 5 MPa and the sintering temperature is 720 to 850° C. for 15 to 60 minutes, and the temperature of the first sintering step is at least 10° C. higher than that of the second sintering step; d) Subjecting the sintered magnet of step c) to an annealing treatment.

Abstract: The disclosure discloses a NdFeB permanent magnet and a preparation method thereof. The magnet is composed of main phase I, a shell structure, a grain boundary phase adjacent to the shell structure, a main phase II, a Ga rich region and a Cu rich region. The magnet has high remanence, high coercivity, and high magnetic energy. In addition, this method can significantly reduce the production cost.

Abstract: The present disclosure relates generally to a method for improving the performance of sintered NdFeB magnet. A method of preparing a sintered NdFeB magnet therefore comprises the steps of: a) preparing alloy flakes from a raw material of the NdFeB magnet by a strip casting process; and b) preparing a coarse alloy powder from the alloy flakes by a hydrogen decrepitation process, the hydrogen decrepitation process including treatment of the alloy flakes under a hydrogen pressure of 0.10 MPa to 0.25 MPa for a duration of 1 to 3.5 hours, then degassing the hydrogen at a predetermined temperature between 300° C. to 400° C. for a duration time of 0.5 to 5 hours, and then mixing the resulting coarse alloy powder with a lubricant.

Abstract: The disclosure refers to a preparation method for NdFeB permanent magnet including: a) Preparing main alloy flakes consisting of (Pr2Nd8)xFe100-x-y-zByMz,where M is at least one of Al,Co,Cu,Ga,Ti and Zr, 28.5 wt. % ?x?31.0 wt. %,0.85 wt. %?y?0.98 wt. % and 0.5 wt. %?z?5.0 wt. %; b) Preparing auxiliary alloy flakes consisting of LuFe100-u-v-wBvMw,where L is at least one ofPr and Nd,M is at least one of Al,Co,Cu,Ga,Ti and Zr, 35.0 wt. %?u?45.0 wt. %,0 wt. %?v?5.0 wt. % and 2.0 wt. %?w?10.0 wt.

Abstract: The present disclosure refers to a method for preparing sintered NdFeB magnets, including: a) Preparing alloy flakes from a raw material by strip casting, performing a hydrogen decrepitation to produce alloy pieces, pulverization the alloy pieces to an alloy powder, performing molding and orientation, cold isostatic pressing, and getting a green compact; b) Putting the green compact into a vacuum furnace and performing a first sintering step in 830 to 880° C. for 2 to 10 hours and 5×10?1 Pa or less; c) Performing a second sintering step while applying a pressure to the green compact achieved by step b), the pressure is 1 MPa to 5 MPa and the sintering temperature is 720 to 850° C. for 15 to 60 minutes, and the temperature of the first sintering step is at least 10° C. higher than that of the second sintering step; d) Subjecting the sintered magnet of step c) to an annealing treatment.

Abstract: The present disclosure refers to a method of preparing a NdFeB magnet powder. The method includes a hydrogen treatment process including the steps of: a) charging NdFeB alloy flakes into a hydrogen treatment furnace, wherein the NdFeB alloy flakes include a neodymium-rich phase and a main phase; b) performing a hydrogen absorption by heating the hydrogen treatment furnace in a first stage to a temperature at which only the neodymium-rich phase undergoes a hydrogen absorption reaction, then introducing and maintaining hydrogen at a predetermined pressure until the hydrogen absorption of the neodymium-rich phase is finished, then stop heating of the hydrogen treatment furnace in a second stage, where the temperature falls to a temperature at which the main phase undergoes a hydrogen absorption reaction; and c) when the hydrogen absorption of step b) is finished, performing a vacuum dehydrogenation of the obtained coarse magnet powder.

Abstract: The present disclosure refers to a preparation method for improving the coercive force of a sintered Nd—Fe—B magnet and comprises: preparing Nd—Fe—B alloy flakes by a strip casting process, followed by hydrogen decrepitation of the Nd—Fe—B alloy flakes and jet milling to obtain an Nd—Fe—B powder; mixing Nd—Fe—B powder and an amount of 0.1 to 5 wt. % of a nanoparticulate powder in a powder mixing machine to obtain a powder mixture; modification of the powder mixture obtained in step B) under inert conditions in a mechanical mixing equipment such that the particles of the Nd—Fe—B powder are rounded and the nanoparticulate powder adheres to the particle surface of the Nd—Fe—B powder; mixing in a lubricant to the modified Nd—Fe—B powder in a powder mixing machine; and align pressing the modified Nd—Fe—B powder into a green body, sintering the green body, and aging of the obtained sintered Nd—Fe—B magnet.

Abstract: The present disclosure relates generally to a method for improving the performance of sintered NdFeB magnet. A method of preparing a sintered NdFeB magnet therefore comprises the steps of: a) preparing alloy flakes from a raw material of the NdFeB magnet by a strip casting process; and b) preparing a coarse alloy powder from the alloy flakes by a hydrogen decrepitation process, the hydrogen decrepitation process including treatment of the alloy flakes under a hydrogen pressure of 0.10 MPa to 0.25 MPa for a duration of 1 to 3.5 hours, then degassing the hydrogen at a predetermined temperature between 300° C. to 400° C. for a duration time of 0.5 to 5 hours, and then mixing the resulting coarse alloy powder with a lubricant.

Abstract: A method of making a finished Nd—Fe—B magnet includes a first step of providing a rare earth magnet powder. Then, a green compact is formed using the rare earth magnet powder. The green compact includes at least one orientation surface, at least one non-orientation surface, and at least one pressing surface. Next, the green compact is cut using a cutting apparatus along the at least one orientation surface, the at least one non-orientation surface, or the at least one pressing surface, under an inert atmosphere to produce a plurality of sliced compacts. Then, the sliced compacts are sintered to produce sintered compacts. The sintered compacts are annealed to produce annealed compacts. The annealed compacts are then machined to obtain finished Nd—Fe—B magnets. The step of cutting is performed before the steps of sintering, annealing, and machining. A cutting apparatus for cutting the green compact is also disclosed herein.

Abstract: Certain embodiments of the present disclosure are directed to a stretch removable adhesive tape comprising a thermoplastic polyurethane film having a unique combination of properties leading to a unique stretch removal profile.

Abstract: Certain embodiments of the present disclosure are directed to a stretch removable adhesive tape comprising a thermoplastic polyurethane film having a unique combination of properties leading to a unique stretch removal profile.

Abstract: Embodiments of the present disclosure relate to adhesive tapes containing an adhesive resin and a crosslinkable component. The novel tapes can exhibit synergistic improvements in parameters such as modulus, overlap shear strength, shelf life, and others.

Abstract: Embodiments of the present disclosure relate to adhesive compositions containing an adhesive resin and a crosslinkable component. The novel compositions can exhibit synergistic improvements in parameters such as modulus, overlap shear strength, shelf life, and others.

Abstract: The invention is directed to a chimeric gammaretrovirus comprising an gammaretroviral virion which contains a lentiviral Vpx protein and methods of use thereof. In a particular aspect, the chimeric gammaretrovirus is a chimeric murine leukemia virus (MLV) comprising an MLV virion which contains a lentiviral Vpx protein. The invention is also directed to use of the chimeric gammaretrovirus to produce a MLV that can transduce a non-dividing cell (G1/S/G2), transduce a non-dividing cell; enhance the ability of a MLV to transduce a non-dividing cell; transduce a quiescent (G0) cell; and enhance the ability of a human immunodeficiency virus 1 (HIV-1) to transduce a quiescent (G0) cell.

Abstract: The invention is directed to a chimeric gammaretrovirus comprising an gammaretroviral virion which contains a lentiviral Vpx protein and methods of use thereof.