Abstract: The present disclosure relates generally to novel recombinant coronavirus-based fusion proteins (“RBDs-IgG Fc protein” and “RBDs protein”) and vaccine compositions using the same, in which the fusion proteins comprise tandemly arranged coronaviruses receptor binding domains (RBDs). The present disclosure further provides methods and kits for immunizing a subject using the compositions.

Abstract: Embodiments of this application provide a method for communication between public cloud-based VPCs and a related product. The method includes the following steps. A cloud management platform determines first configuration information entered or selected by a tenant, and creates a global VPC based on the first configuration information. The cloud management platform determines second configuration information entered or selected by the tenant, and allocates, based on the second configuration information through the global VPC, a first network prefix to a first VPC located in a first region, and a second network prefix to a second VPC located in a second region, where the global VPC is used to implement cross-region communication between the first VPC and the second VPC based on the first network prefix and the second network prefix.

Abstract: Disclosed are peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a neonatal receptor (FcRn); a modified pre-fusion respiratory syncytia virus (RSV) F protein; and a trimerization domain. Disclosed are nucleic acid sequences capable of encoding peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a neonatal receptor (FcRn); a modified pre-fusion respiratory syncytia virus (RSV) F protein; and a trimerization domain. Also disclosed are methods for eliciting a protective immune response against RSV comprising administering to a subject an effective amount of a composition comprising a monomeric Fc fragment of an immunoglobulin recognized by FcRn; a modified pre-fusion RSV F protein; and a trimerization domain, wherein the administering is to a mucosal epithelium.

Abstract: An address space recommendation method is provided, including: obtaining an address space recommendation request sent by a client for a first VPC, wherein the address space recommendation request includes an identifier of a first alliance relationship; and determining, in response to the address space recommendation request, a first address space different from a second address space corresponding to a second VPC, wherein the first VPC and the second VPC have the first alliance relationship; and outputting the first address space to the client. Because the first address space that does not have an address conflict with another VPC in an alliance relationship may be automatically recommended for a VPC, a user does not need to manually configure an address space for the VPC.

Abstract: HCMV US11 based therapeutics that can be used to target and reduce the activity of the FcRn protein are provided. The compositions can be used in treatment of auto-immune mediated and albumin-mediated diseases in a subject HCMV US11, as well as for use in preventing, or treating, infections of HCMV through administration of a US11 inhibitor.

Abstract: The present disclosure belongs to the technical field of casting, and specifically relates to a high-inertia mold shell for casting, a preparation method thereof, and a method for improving precision of a magnesium alloy cast. The high-inertia mold shell for casting includes a surface layer, which is configured to contact a magnesium alloy pouring liquid, wherein the surface layer contains an inorganic compound, and the inorganic compound is at least one selected from the group consisting of boric anhydride, borax, potassium fluoride, and sodium fluoride; and in the above, based on a total amount of raw materials of the surface layer, a content of the inorganic compound accounts for 10-40 wt %.

Abstract: In a memory management method, a first processor in a system is associated with at least two different types of memory media. After obtaining a memory allocation request, the first processor fully considers physical attributes such as a memory capacity, an access latency, a cost, or a service life of the multiple different types of memory media in the system when allocating a memory resource to a running application. The processor selects a to-be-allocated memory resource from the multiple different types of memory media based on a low access latency of the first processor accessing an allocated memory resource.

Abstract: Disclosed are peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; SARS-CoV-2 antigen; and a trimerization domain. Disclosed are peptide complexes comprising three peptides, wherein each of the three peptides comprises a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; SARS-CoV-2 antigen; and a trimerization domain. Disclosed are compositions comprising any of the disclosed peptides or peptide complexes. Disclosed are methods for eliciting a protective immune response against SARS-CoV-2 comprising administering to a subject an effective amount of one or more of the compositions disclosed herein. Disclosed are methods of treating a subject exposed to SARS-CoV-2 or at risk of being exposed to SARS-CoV-2 comprising administering to a subject an effective amount of one or more of the compositions disclosed herein.

Abstract: In a data processing method implemented in a hierarchical memory system including a first memory medium and a second memory medium of different types, a processor obtains data distribution in the hierarchical memory system. The processor determines a data migration manner based on the data distribution, where the data migration manner is for implementing migration processing on a migration data set between the different memory media based on the data distribution. The processor then performs migration processing on the migration data set based on the migration manner.

Abstract: A method for controlling an internal memory bandwidth includes after obtaining a bandwidth required by a to-be-accessed internal memory medium, a processor in a system obtains an occupancy rate of an internal memory bandwidth of the to-be-accessed internal memory medium. If determining, based on the occupancy rate of the internal memory bandwidth, that the to-be-accessed internal memory medium cannot satisfy a bandwidth requirement, the processor adjusts, under an indication of a bandwidth adjustment policy, the occupancy rate of the internal memory bandwidth based on a factor that affects the occupancy rate of the internal memory bandwidth of the to-be-accessed internal memory medium, and the processor uses a first bandwidth that satisfies the bandwidth requirement in an adjusted remaining bandwidth of the to-be-accessed internal memory medium.

Abstract: A bandwidth scheduling method includes receiving a bandwidth request sent by a data center, where the bandwidth request includes bandwidth required to transmit non-real-time traffic; allocating, based on historical bandwidth information, the bandwidth required by the data center to transmit the non-real-time traffic in a future time period, where the historical bandwidth information is used to predict occupation of total bandwidth by the data center in a region in which the data center is located at each moment in the future time period; and sending a bandwidth response to the data center, where the bandwidth response includes an allocation result.

Abstract: An application of Longhu Rendan in preparing a medicament for preventing and/or treating liver fibrosis. The Longhu Rendan has significant effect in improving fibrosis, and its effect in anti-liver fibrosis and liver protection is equivalent to those of a positive drug silybin.

Abstract: Disclosed are peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a neonatal receptor (FcRn); an influenza HA protein; and a trimerization domain. Disclosed are compositions comprising one or more of the peptides described herein. Disclosed are nucleic acid sequences capable of encoding any one of the peptides described herein. Disclosed are methods for eliciting a protective immune response against influenza comprising administering to a subject an effective amount of a composition comprising a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; an influenza HA protein; and a trimerization domain, wherein the administering is to a mucosal epithelium.

Abstract: A wireless charging system is configured to charge one or more receiver devices simultaneously. The wireless charging system includes multiple coils that may be driven independently based on a feedback system with one or more feedback channels. Each coil is driven by a coil driving signal selected based on a set of target characteristics. A coil drive circuit receives an input of a pulse width modulation (PWM) signal and outputs the coil driving signal to a corresponding coil.

Abstract: This application discloses a method for multi-cloud interconnection, including: receiving identification information of a first device deployed on a first VPC; determining, based on the identification information of the first device, a first edge node, that is configured to connect to the first VPC, among a plurality of network nodes; sending identification information of the first edge node to the first device, where the identification information of the first edge node is used by the first device to create a connection between the first device and the first edge node; and determining a forwarding path that is between the first edge node and a second edge node and that is used to forward a packet between the first VPC and a second VPC, where the second edge node is a network node, that is configured to connect to the second VPC, among the plurality of network nodes.

Abstract: The present disclosure is drawn to HCMV US11 based therapeutics that can be used to target and reduce the activity of the FcRn protein. The disclosure provides a method of treating auto-immune mediated and albumin-mediated diseases in a subject comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising HCMV US11 (herein after referred to as “US11”) polypeptide, polypeptide fragments, or variants thereof. The disclosure also provides methods for preventing, or treating, infections of HCMV through administration of a US11 inhibitor. US11 containing vaccine compositions are also provided for stimulation of an anti-US11 immune response for protection against HCMV infection.

Abstract: Example data transmission methods, processor systems, and memory access systems are provided. One example processor system is applied to a source end device. The processor system includes a processor core and a first remote direct memory access (RDMA) network interface card. The processor core is configured to deliver a memory write instruction. The memory write instruction includes to-be-written data and a destination address of the to-be-written data. The destination address is a memory address of a destination end device. The first RDMA network interface card is configured to encapsulate the to-be-written data based on the destination address of the to-be-written data and configuration information of the destination end device and send the encapsulated to-be-written data to a second RDMA network interface card of the destination end device.

Abstract: Disclosed are peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a neonatal receptor (FcRn); an influenza HA protein; and a trimerization domain. Disclosed are compositions comprising one or more of the peptides described herein. Disclosed are nucleic acid sequences capable of encoding any one of the peptides described herein. Disclosed are methods for eliciting a protective immune response against influenza comprising administering to a subject an effective amount of a composition comprising a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; an influenza HA protein; and a trimerization domain, wherein the administering is to a mucosal epithelium.

Abstract: Disclosed are peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a neonatal receptor (FcRn); a modified pre-fusion respiratory syncytia virus (RSV) F protein; and a trimerization domain. Disclosed are nucleic acid sequences capable of encoding peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a neonatal receptor (FcRn); a modified pre-fusion respiratory syncytia virus (RSV) F protein; and a trimerization domain. Also disclosed are methods for eliciting a protective immune response against RSV comprising administering to a subject an effective amount of a composition comprising a monomeric Fc fragment of an immunoglobulin recognized by FcRn; a modified pre-fusion RSV F protein; and a trimerization domain, wherein the administering is to a mucosal epithelium.

Abstract: This application discloses a method for multi-cloud interconnection, including: receiving identification information of a first device deployed on a first VPC; determining, based on the identification information of the first device, a first edge node, that is configured to connect to the first VPC, among a plurality of network nodes; sending identification information of the first edge node to the first device, where the identification information of the first edge node is used by the first device to create a connection between the first device and the first edge node; and determining a forwarding path that is between the first edge node and a second edge node and that is used to forward a packet between the first VPC and a second VPC, where the second edge node is a network node, that is configured to connect to the second VPC, among the plurality of network nodes.