Abstract: A monoclonal antibody specifically binding to human and monkey CD38 antigens or a derivative thereof includes: antigen complementarity-determining regions CDR1, CDR2 and CDR3 of an antibody light chain variable region having amino acid sequences as set forth in SEQ ID NO: 3, SEQ ID NO: 4 and SEQ ID NO: 5, respectively; and antigen complementarity-determining regions CDR1, CDR2 and CDR3 of an antibody heavy chain variable region having amino acid sequences as set forth in SEQ ID NO: 8, SEQ ID NO: 9 and SEQ ID NO: 10, respectively. The monoclonal antibody or derivative thereof can be used as a component of a pharmaceutical composition or prepared into a suitable pharmaceutical preparation, administered alone or combined with other therapeutic means such as chemotherapy drugs, for treating tumors with positive CD38 expression, such as human myeloma and human lymphoma.

Abstract: Additive manufacturing (AM) methods and devices for high-melting-point materials are disclosed. In an embodiment, an additive manufacturing method includes the following steps. (S1) Slicing a three-dimensional computer-aided design model of a workpiece into multiple layers according to shape, thickness, and size accuracy requirements, and obtaining data of the multiple layers. (S2) Planning a forming path according to the data of the multiple layers and generating computer numerical control (CNC) codes for forming the multiple layers. (S3) Obtaining a formed part by preheating a substrate, performing a layer-by-layer spraying deposition by a cold spraying method, and heating a spray area to a temperature until the spraying deposition of all sliced layers is completed. (S4) Subjecting the formed part to a surface modification treatment by a laser shock peening method.

Abstract: Additive manufacturing (AM) methods and devices for high-melting-point materials are disclosed. In an embodiment, an additive manufacturing method includes the following steps. (S1) Slicing a three-dimensional computer-aided design model of a workpiece into multiple layers according to shape, thickness, and size accuracy requirements, and obtaining data of the multiple layers. (S2) Planning a forming path according to the data of the multiple layers and generating computer numerical control (CNC) codes for forming the multiple layers. (S3) Obtaining a formed part by preheating a substrate, performing a layer-by-layer spraying deposition by a cold spraying method, and heating a spray area to a temperature until the spraying deposition of all sliced layers is completed. (S4) Subjecting the formed part to a surface modification treatment by a laser shock peening method.

Abstract: The present invention belongs to the field of multi-material additive manufacturing (AM), and in particular discloses a forming system and method of hybrid AM and surface coating. The hybrid forming system includes an additive forming device, a laser-assisted cold spraying (LACS) device and a workbench. The additive forming device and the LACS device are located above the workbench. During manufacturing, the additive forming device forms a part to be formed on the workbench layer by layer, and the LACS device performs coating peening treatment on inner and outer surfaces of the part to be formed during the forming process, thereby jointly completing the composite manufacturing of the part to be formed. The present invention makes full use of the rapid prototyping advantage of the short-flow AM process, and integrates the surface coating peening process into the hybrid forming system.

Abstract: The present invention belongs to the field of multi-material additive manufacturing (AM), and in particular discloses a forming system and method of hybrid AM and surface coating. The hybrid forming system includes an additive forming device, a laser-assisted cold spraying (LACS) device and a workbench. The additive forming device and the LACS device are located above the workbench. During manufacturing, the additive forming device forms a part to be formed on the workbench layer by layer, and the LACS device performs coating peening treatment on inner and outer surfaces of the part to be formed during the forming process, thereby jointly completing the composite manufacturing of the part to be formed. The present invention makes full use of the rapid prototyping advantage of the short-flow AM process, and integrates the surface coating peening process into the hybrid forming system.

Abstract: Additive manufacturing (AM) methods and devices for high-melting-point materials are disclosed. In an embodiment, an additive manufacturing method includes the following steps. (S1) Slicing a three-dimensional computer-aided design model of a workpiece into multiple layers according to shape, thickness, and size accuracy requirements, and obtaining data of the multiple layers. (S2) Planning a forming path according to the data of the multiple layers and generating computer numerical control (CNC) codes for forming the multiple layers. (S3) Obtaining a formed part by preheating a substrate, performing a layer-by-layer spraying deposition by a cold spraying method, and heating a spray area to a temperature until the spraying deposition of all sliced layers is completed. (S4) Subjecting the formed part to a surface modification treatment by a laser shock peening method.