Abstract: A graft copolymer and a preparation method and use thereof. The method for preparing a graft copolymer includes: dissolving an N-ethyl-2-pyrrolidinone-substituted flavan-3-ol (EPSF) and a starch in a polar organic solvent, to obtain a raw material solution; and mixing the raw material solution with ascorbic acid and hydrogen peroxide to obtain a mixture, and subjecting the mixture to a grafting reaction, to obtain the graft copolymer.

Abstract: Provided is an EGFR kinase inhibitor according to general formula (I) and a pharmaceutical composition containing the inhibitor. The invention can be used to treat diseases related to EGFR kinase, such as cancer. Also provided is a preparation and use of the above inhibitor.

Abstract: A new compound of general formula (X) inhibiting and inducing degradation of an EGFR and ALK, and a pharmaceutical composition containing said compound. The compound and the pharmaceutical composition can be used for treating diseases related to the EGFR and the ALK kinase, such as cancer. The present invention further provides the preparation and use of the compound.

Abstract: The application relates to the production of a soiled fabric, and more particularly to a method of manufacturing a standard carbon black soiled fabric for performance testing of washing machines. Water is adopted herein as the solvent to prepare a soil, which renders this method safe, environmentally friendly and economical. Moreover, this method introduces a fully-automatic continuous rolling-suction tentering and setting machine to control the pressure of the padder, the drying temperature, the air volume of the fan and the speed of chains, which reduces the manual intervention, achieving a highly-automatic printing and dyeing process. The reflectivity at four points on both sides of the standard carbon black soiled fabric according to the invention is 95% or more.

Abstract: The present invention relates to a liquid, propellant-free pharmaceutical formulation and a method for administering the pharmaceutical formulation by nebulizing the pharmaceutical formulation with an inhaler. The propellant-free pharmaceutical formulation comprises: (a) the active substance tiotropium bromide; (b) a solvent; (c) a pH adjusting agent, and optionally other pharmacologically acceptable additives.

Abstract: The present invention relates to a liquid, propellant-free pharmaceutical preparation and a method for administering the pharmaceutical preparation by nebulizing the pharmaceutical preparation in an inhaler. The propellant-free pharmaceutical preparation comprises a solvent, Tiotropium or a pharmaceutically acceptable salt thereof, Olodaterol or a pharmaceutically acceptable salt thereof, a pH adjusting agent, and a pharmacologically acceptable additive.

Abstract: The application relates to the production of a soiled fabric, and more particularly to a method of manufacturing a standard carbon black soiled fabric for performance testing of washing machines. Water is adopted herein as the solvent to prepare a soil, which renders this method safe, environmentally friendly and economical. Moreover, this method introduces a fully-automatic continuous rolling-suction tentering and setting machine to control the pressure of the padder, the drying temperature, the air volume of the fan and the speed of chains, which reduces the manual intervention, achieving a highly-automatic printing and dyeing process. The reflectivity at four points on both sides of the standard carbon black soiled fabric according to the invention is 95% or more.

Abstract: A method of directional label rectification with adaptive graph for multivariate time-series data includes obtaining an input matrix containing sensor data and a first event matrix containing event data, identifying in the input matrix at least one feature pattern and a first corresponding time stamp, identifying in the first event matrix at least one fault signature and a second corresponding time stamp, if both a label matrix and an affinity matrix are known, then optimizing a weight matrix, else if both the label matrix and the weight matrix are known, then optimizing the affinity matrix, else optimizing the label matrix, creating a dynamically rectified event matrix by applying the label matrix, the affinity matrix, and the weight matrix to the first event matrix; and applying the dynamically rectified event matrix to forecast a future status of the asset. A system and computer-readable medium are disclosed.

Abstract: A method of directional label rectification with adaptive graph for multivariate time-series data includes obtaining an input matrix containing sensor data and a first event matrix containing event data, identifying in the input matrix at least one feature pattern and a first corresponding time stamp, identifying in the first event matrix at least one fault signature and a second corresponding time stamp, if both a label matrix and an affinity matrix are known, then optimizing a weight matrix, else if both the label matrix and the weight matrix are known, then optimizing the affinity matrix, else optimizing the label matrix, creating a dynamically rectified event matrix by applying the label matrix, the affinity matrix, and the weight matrix to the first event matrix; and applying the dynamically rectified event matrix to forecast a future status of the asset. A system and computer-readable medium are disclosed.

Abstract: A liquid crystal Fresnel lens is provided. The liquid crystal Fresnel lens includes a liquid crystal cell and two polarizers. The liquid crystal cell includes: two transparent substrates having conducting layers disposed thereon with alignment layers, wherein an alignment pattern formed by the alignment layers are configured to provide multiple alignment domains in a Fresnel zones pattern, and wherein an easy axis of adjacent alignment domains are oriented at an angle relative to one another; and a ferroelectric liquid crystal layer disposed between the two transparent substrates, wherein the ferroelectric liquid crystal layer has a planar surface orientation and smectic layers perpendicular to the two transparent substrates. The liquid crystal cell is disposed between the two polarizers.

Abstract: A method for real-time and in-situ monitoring of freeze-thaw damage to concrete, comprising embedding pairs of gradient electrical resistance probes into a surface of concrete being monitored at a depth of 0-50 mm, the paired gradient electrical resistance probes having an anti-corrosion metal bar, with the buried depth gradient of different pairs of electrical resistance probes being in the range of 1 mm to 20 mm, and the buried depth gradient of the pair of electrical resistance probes nearest to the surface being less than 5 mm; transmitting an impedance value of the concrete measured by the paired gradient electrical resistance probes to a monitoring center for processing; and evaluating a spalling status of freeze-thaw damage to the concrete based on changes in impedance value which may be abrupt. Real-time in-situ monitoring of the freeze-thaw damage of concrete can be achieved by the electrical resistance probes and monitoring center of this invention.

Abstract: A liquid crystal Fresnel lens is provided. The liquid crystal Fresnel lens includes a liquid crystal cell and two polarizers. The liquid crystal cell includes: two transparent substrates having conducting layers disposed thereon with alignment layers, wherein an alignment pattern formed by the alignment layers are configured to provide multiple alignment domains in a Fresnel zones pattern, and wherein an easy axis of adjacent alignment domains are oriented at an angle relative to one another; and a ferroelectric liquid crystal layer disposed between the two transparent substrates, wherein the ferroelectric liquid crystal layer has a planar surface orientation and smectic layers perpendicular to the two transparent substrates. The liquid crystal cell is disposed between the two polarizers.

Abstract: Method for real-time and online monitoring the freeze-thaw damage of concrete, firstly, embed pairs of gradient electrical resistance probes into surface of the monitoring concrete at the depth of 0˜50 mm, the paired gradient electrical resistance probes adopt anti-corrosion metal bar, and the buried depth gradient of different pairs of electrical resistance probes in the range of 1 mm to 20 mm, and the buried depth gradient of the pair of electrical resistance probes nearest to the surface is less than 5 mm. Transmit the impedance value of the concrete measured by the paired gradient electrical resistance probes to the monitor center for processing. Judge the spalling status of freeze-thaw damage of concrete though the abrupt change in impedance value. Real-time online monitoring of the freeze-thaw damage of concrete can be achieved by the electrical resistance probes and monitoring center of this invention.