Abstract: A method, system and device for binding and operating a Secure Digital memory card (SD card) include: after an identification number of a SIM card is sent to the SD card, the SD card does not immediately establish the binding relationship with the SIM card; instead, the SD card establishes the corresponding relationship with the SIM card according to an authentication-passed message returned from an SD server, when the SD server determines that the identification number of the SIM card installed in the mobile terminal, which sends an authentication request, is the same as that of the SIM card in the authentication request; and then, while the services in the SD card are operating, the SD card side and the SD server side determine whether to allow the SD card to response to the services according to the binding relationship between the SD card and the SIM card, thus the security of the application of the service data in the SD card is improved.