Abstract: This disclosure relates to bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and to methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such bivalent compounds.

Abstract: Provided are bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof, and methods for identifying such bivalent compounds.

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

Abstract: Disclosed are a method for communication, an electronic device, and a computer-readable storage medium. The method includes: determining a first target frequency based on historical sensed information of a destination node; transmitting an RTS frame to the destination node at the first target frequency, where the destination node obtains first sensed information of the source node from the RTS frame, and determines a first optimal receiving frequency of the source node based on the first sensed information; receiving a CTS frame transmitted by the destination node at the first optimal receiving frequency; obtaining second sensed information of the destination node from the CTS frame; determining a second optimal receiving frequency of the destination node based on the second sensed information; transmitting a data frame to the destination node at the second optimal receiving frequency; and receiving an ACK frame transmitted by the destination node at the first optimal receiving frequency.

Abstract: A computer-implemented method for improving intercommunication and software quality among a geographically distributed team is disclosed. The method comprises automatically determining a location of each member of the team; automatically obtaining one or more objective measures of contributions by each member of the team to a collaborative project; based at least in part on the automatically determined locations and automatically obtained objective measures, calculating for each member of the team a normalized collaboration score, and based on values of collaboration scores calculated for each member of the team, generating an electronic message for delivery to a computing device to cause the computing device to act in accordance with an instruction contained within the electronic message.