Abstract: A forced separation device includes a transmission shaft, a main shaft, an electromagnetic transmission mechanism, a blasting separation mechanism and a pressure-resistant cabin. A pressing cover is fastened to the upper portion of the pressure-resistant cabin. The electromagnetic transmission mechanism is provided with a driving chuck and a driven chuck. The driving chuck is connected with the transmission shaft, the driven chuck is connected with the main shaft, the pressing cover is welded with the transmission shaft, and the driven chuck is welded with the lower portion of the pressure-resistant cabin. The blasting separation mechanism is provided with explosive packages and detonators. A plurality of explosive packages are distributed between the pressing cover and the top surface of the pressure-resistant cabin, and each explosive package is connected with the corresponding detonator respectively. The pressure-resistant cabin is further internally provided with a storage battery.

Abstract: A forced separation device for a submarine drilling machine and a drilling tool comprises a transmission shaft, a main shaft, an electromagnetic transmission mechanism, a blasting separation mechanism and a pressure-resistant cabin, a gland is fastened to the upper portion of the pressure-resistant cabin, the electromagnetic transmission mechanism is provided with a driving sucker and a driven sucker, the driving sucker is connected with the transmission shaft, the driven sucker is connected with the main shaft, the gland is welded with the transmission shaft, and the driven sucker is welded with the lower portion of the pressure-resistant cabin; the blasting separation mechanism is provided with explosive packages and detonators, a plurality of explosive packages are distributed between the gland and the top surface of the pressure-resistant cabin, and each explosive package is connected with the corresponding detonator respectively; and the pressure-resistant cabin is further internally provided with a stor

Abstract: The present invention relates to a novel peptide sequence named PIMAP39 (herein referred to as SEQ ID NO.: 1) and methods of use of the novel sequence and functional variants thereof. The present invention also relates to methods for reducing and/or modulating inflammatory responses by administration of the peptide of the present invention. Furthermore, the present invention relates to the modulation of the expression of cytokines effected as part of an inflammatory response by administration of the peptide of the present invention.

Abstract: The present invention relates to a novel peptide sequence named PIMAP39 (herein referred to as SEQ ID NO.: 1) and methods of use of the novel sequence and functional variants thereof. The present invention also relates to methods for reducing and/or modulating inflammatory responses by administration of the peptide of the present invention. Furthermore, the present invention relates to the modulation of the expression of cytokines effected as part of an inflammatory response by administration of the peptide of the present invention.

Abstract: The invention provides molecules containing nucleic acid sequences for fragments of LPS-induced TNF-? factor (LITAF) and vectors containing these sequences. Also provided are molecules that contain the peptide sequence SQTWREPGAAGSPFHL (SEQ ID NO: 5), or homologs thereof. Such molecules may be useful in the treatment of diseases that relate to the expression of TNF-?, where treatment involves the modulation of this expression. The invention also provides methods for identifying compounds that inhibit or enhance the transcription of TNF-?.

Abstract: The present invention relates to a novel isolated and purified peptide of the sequence KQSQHMT [SEQ ID NO: 1], nucleic acid sequences encoding said peptide sequence and capable of expressing said sequence as an exogenous protein in a target cell; as well as methods for the reduction or inhibition of LITAF activity by transfecting the peptide KQSQHMT [SEQ ID NO: 1] or a nucleic acid capable of expressing said peptide, into a target cell. The present invention also relates to the use of the novel peptide (and corresponding nucleotide sequences) of the present invention for the regulation of cytokine expression in target cells. The present invention also relates to the use of the novel peptide (and corresponding nucleotide sequences) of the present invention for the regulation of inflammatory responses in mammals.

Abstract: The invention provides molecules containing nucleic acid sequences for fragments of LPS-induced TNF-? factor (LITAF) and vectors containing these sequences. Also provided are molecules that contain the peptide sequence SQTWREPGAAGSPFHL, or homologs thereof. Such molecules may be useful in the treatment of diseases that relate to the expression of TNF-?, where treatment involves the modulation of this expression. The invention also provides methods for identifying compounds that inhibit or enhance the transcription of TNF-?.

Abstract: The present invention relates to novel proteins (LITAF and STAT6(B)) and the nucleotide sequences encoding the same. The present invention also relates to the use of the novel peptides and nucleotide sequences of the present invention, or functional fragments thereof, for the regulation of cytokine expression. The present invention also relates to the use of the novel proteins and nucleotides sequences of the present invention for the regulation of inflammatory responses in mammals including the regulation of angiogenesis and tubulogenesis. Also in this regard, the present invention relates to the generation of null mutant animals deficient in the expression of one or both of the proteins of the present invention.

Abstract: The invention provides molecules containing nucleic acid sequences for fragments of LPS-induced TNF-? factor (LITAF) and vectors containing these sequences. Also provided are molecules that contain the peptide sequence SQTWREPGAAGSPFHL, or homologs thereof. Such molecules may be useful in the treatment of diseases that relate to the expression of TNF-?, where treatment involves the modulation of this expression. The invention also provides methods for identifying compounds that inhibit or enhance the transcription of TNF-?.

Abstract: The invention provides molecules containing nucleic acid sequences for fragments of LPS-induced TNF-&agr; factor (LITAF) and vectors containing these sequences. Also provided are molecules that contain the peptide sequence SQTWREPGAAGSPFHL, or homologs thereof. Such molecules may be useful in the treatment of diseases that relate to the expression of TNF-&agr;, where treatment involves the modulation of this expression. The invention also provides methods for identifying compounds that inhibit or enhance the transcription of TNF-&agr;.