Patents by Inventor Xiaorong Liu
Xiaorong Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9770432Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.Type: GrantFiled: June 14, 2016Date of Patent: September 26, 2017Assignee: Guangzhou Institutes of Biomedicine And Health, Chinese Academy of SciencesInventors: Yanmei Zhang, John Jeffrey Talley, Mark G. Obukowicz, Zhengchao Tu, Micky Tortorella, Yican Wang, Jianqi Liu, Yan Chen, Xiaorong Liu, Xin Lu
-
Patent number: 9763914Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.Type: GrantFiled: June 14, 2016Date of Patent: September 19, 2017Assignee: Guangzhou Institutes of Biomedicine And Health, Chinese Academy of SciencesInventors: Yanmei Zhang, John Jeffrey Talley, Mark G. Obukowicz, Zhengchao Tu, Micky Tortorella, Yican Wang, Jianqi Liu, Yan Chen, Xiaorong Liu, Xin Lu
-
Publication number: 20170020843Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.Type: ApplicationFiled: June 14, 2016Publication date: January 26, 2017Inventors: Yanmei ZHANG, John Jeffrey TALLEY, Mark G. OBUKOWICZ, Zhengchao TU, Micky TORTORELLA, Yican WANG, Jianqi LIU, Yan CHEN, Xiaorong LIU, Xin LU
-
Patent number: 9478364Abstract: Carbon-based electrodes such as for incorporation into ultracapacitors or other high power density energy storage devices, include activated carbon, carbon black, binder and at least one molecular sieve material. The molecular sieve component can adsorb and trap water, which can facilitate the use of the device at higher voltage, such as greater than 3V. The molecular sieve material may be incorporated into the carbon-based electrodes or formed as a layer over a carbon-based electrode surface.Type: GrantFiled: January 28, 2014Date of Patent: October 25, 2016Assignee: Corning IncorporatedInventors: Kishor Purushottam Gadkaree, Atul Kumar, Xiaorong Liu
-
Publication number: 20160287556Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.Type: ApplicationFiled: June 14, 2016Publication date: October 6, 2016Inventors: Yanmei ZHANG, John Jeffrey TALLEY, Mark G. OBUKOWICZ, Zhengchao TU, Micky TORTORELLA, Yican WANG, Jianqi LIU, Yan CHEN, Xiaorong LIU, Xin LU
-
Patent number: 9371305Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.Type: GrantFiled: August 10, 2012Date of Patent: June 21, 2016Assignee: Guangzhou Institutes of Biomedicine And Health, Chinese Academy of SciencesInventors: Yanmei Zhang, John Jeffrey Talley, Mark G. Obukowicz, Zhengchao Tu, Micky Tortorella, Yican Wang, Jianqi Liu, Yan Chen, Xiaorong Liu, Xin Lu
-
Patent number: 9183994Abstract: A lithium-ion capacitor may include a cathode, an anode, a separator disposed between the cathode and the anode, a lithium composite material, and an electrolyte solution. The cathode and anode may be non-porous. The lithium composite material comprises a core of lithium metal and a coating of a complex lithium salt that encapsulates the core. In use, the complex lithium salt may dissolve into and constitute a portion of the electrolyte solution.Type: GrantFiled: November 28, 2012Date of Patent: November 10, 2015Assignee: CORNING INCORPORATEDInventors: Kishor Purushottam Gadkaree, Xiaorong Liu
-
Patent number: 9139574Abstract: The present invention relates to imidazole, oxazole and thiazole derivatives of tumor-targeted drug combretastatin A4, and phosphate esters, sulfonate esters or pharmaceutically acceptable salts, glycoside derivatives, solvates thereof, wherein the A-ring comprises a 3,5-dimethoxyphenyl group having a substituent at the 4-position. The pharmacological activity assays have demonstrated that the compounds of the present invention have good in vitro anti-tumor activity and excellent tubulin inhibitory effect.Type: GrantFiled: July 4, 2012Date of Patent: September 22, 2015Assignee: Nanjing Sanhome Pharmaceutical Co., Ltd.Inventors: Yong Wang, Cang Zhang, Xiaorong Liu, Yan Zhang, Yunyun Wang, Wenping Zhang
-
Patent number: 9136064Abstract: A method for producing activated carbon includes heating a phenolic novolac resin carbon precursor at a carbonization temperature effective to form a carbon material, and reacting the carbon material with CO2 at an activation temperature effective to form the activated carbon. The resulting activated carbon can be incorporated into a carbon-based electrode of an EDLC. Such EDLC can exhibit a potential window and thus an attendant operating voltage of greater than 3V.Type: GrantFiled: January 28, 2014Date of Patent: September 15, 2015Assignee: Corning IncorporatedInventors: Kishor Purushottam Gadkaree, Andrew Fleitz Husted, Xiaorong Liu
-
Patent number: 9129756Abstract: A lithium-ion capacitor includes a cathode, an anode, and a porous separator positioned between the cathode and the anode. The cathode is formed using activated carbon, and the anode is formed from a composite material that includes lithium titanium oxide and a carbon material such as hard carbon or graphite.Type: GrantFiled: March 28, 2013Date of Patent: September 8, 2015Assignee: Corning IncorporatedInventors: Kishor Purushottam Gadkaree, Xiaorong Liu
-
Publication number: 20150228978Abstract: A lithium ion battery having a cathode and an anode, the cathode includes a material having an olivine or spinel structure, the anode includes a coating of a composite lithium powder coated with a complex lithium salt, such as LiPF6, LiBF4, LiClO4, LiAsF6, LiF3SO3, and mixtures thereof. A separator is disposed between the anode and the cathode, and a non-aqueous electrolyte solution in contact with the cathode, the anode, and the separator. The anode can include a carbon material. A layer of a composite lithium powder coated with a complex lithium salt can be disposed between the anode and the separator.Type: ApplicationFiled: February 6, 2015Publication date: August 13, 2015Inventors: Kishor Purushottam Gadkaree, Xiaorong Liu
-
Publication number: 20150133538Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.Type: ApplicationFiled: August 10, 2012Publication date: May 14, 2015Applicant: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesInventors: Yanmei Zhang, John Jeffrey Talley, Mark G. Obukowicz, Zhengchao Tu, Micky Tortorella, Yican Wang, Jianqi Liu, Yan Chen, Xiaorong Liu, Xin Lu
-
Publication number: 20150055276Abstract: Carbon-based electrodes such as for incorporation into ultracapacitors or other high power density energy storage devices, include activated carbon, carbon black, binder and at least one molecular sieve material. The molecular sieve component can adsorb and trap water, which can facilitate the use of the device at higher voltage, such as greater than 3V. The molecular sieve material may be incorporated into the carbon-based electrodes or formed as a layer over a carbon-based electrode surface.Type: ApplicationFiled: January 28, 2014Publication date: February 26, 2015Applicant: Corning IncorporatedInventors: Kishor Purushottam Gadkaree, Atul Kumar, Xiaorong Liu
-
Publication number: 20150030526Abstract: A method for producing activated carbon includes heating a phenolic novolac resin carbon precursor at a carbonization temperature effective to form a carbon material, and reacting the carbon material with CO2 at an activation temperature effective to form the activated carbon. The resulting activated carbon can be incorporated into a carbon-based electrode of an EDLC. Such EDLC can exhibit a potential window and thus an attendant operating voltage of greater than 3V.Type: ApplicationFiled: January 28, 2014Publication date: January 29, 2015Applicant: Corning IncorporatedInventors: Kishor Purushottam Gadkaree, Andrew Fleitz Husted, Xiaorong Liu
-
Patent number: 8920925Abstract: Stabilized lithium particles include a lithium-containing core and a coating of a complex lithium salt that surrounds and encapsulates the core. The coating, which is a barrier to oxygen and water, enables the particles to be handled in the open air and incorporated directly into electrochemical devices. The coating material is compatible, for example, with electrolytic materials that are used in electrochemical cells. The average coated particle size is less than 500 microns.Type: GrantFiled: November 9, 2012Date of Patent: December 30, 2014Assignee: Corning IncorporatedInventors: Kishor Purushottam Gadkaree, Xiaorong Liu
-
Publication number: 20140293507Abstract: A lithium-ion capacitor includes a cathode, an anode, and a porous separator positioned between the cathode and the anode. The cathode is formed using activated carbon, and the anode is formed from a composite material that includes lithium titanium oxide and a carbon material such as hard carbon or graphite.Type: ApplicationFiled: March 28, 2013Publication date: October 2, 2014Inventors: Kishor Purushottam Gadkaree, Xiaorong Liu
-
Publication number: 20140146440Abstract: A lithium-ion capacitor may include a cathode, an anode, a separator disposed between the cathode and the anode, a lithium composite material, and an electrolyte solution. The cathode and anode may be non-porous. The lithium composite material comprises a core of lithium metal and a coating of a complex lithium salt that encapsulates the core. In use, the complex lithium salt may dissolve into and constitute a portion of the electrolyte solution.Type: ApplicationFiled: November 28, 2012Publication date: May 29, 2014Inventors: Kishor Purushottam Gadkaree, Xiaorong Liu
-
Publication number: 20140134438Abstract: Stabilized lithium particles include a lithium-containing core and a coating of a complex lithium salt that surrounds and encapsulates the core. The coating, which is a barrier to oxygen and water, enables the particles to be handled in the open air and incorporated directly into electrochemical devices. The coating material is compatible, for example, with electrolytic materials that are used in electrochemical cells. The average coated particle size is less than 500 microns.Type: ApplicationFiled: November 9, 2012Publication date: May 15, 2014Applicant: CORNING INCORPORATEDInventors: Kishor Purushottam Gadkaree, Xiaorong Liu
-
Publication number: 20140128384Abstract: The present invention relates to imidazole, oxazole and thiazole derivatives of tumor-targeted drug combretastatin A4, and phosphate esters, sulfonate esters or pharmaceutically acceptable salts, glycoside derivatives, solvates thereof, wherein the A-ring comprises a 3,5-dimethoxyphenyl group having a substituent at the 4-position. The pharmacological activity assays have demonstrated that the compounds of the present invention have good in vitro anti-tumor activity and excellent tubulin inhibitory effect.Type: ApplicationFiled: July 4, 2012Publication date: May 8, 2014Applicant: NANJING SANHOME PHARMACEUTICAL CO., LTD.Inventors: Yong Wang, Cang Zhang, Xiaorong Liu, Yan Zhang, Yunyun Wang, Wenping Zhang
-
Patent number: 6930300Abstract: The method and apparatus for monitoring a photo-detector generates a highly compliant mirror current across a broad range of photo-detector current levels. The apparatus for monitoring includes: a pair of bipolar transistors and a first non-linear isolation element. The pair of transistors are connected in a mirror configuration with a sense transistor one of the pair of transistors sensing a photo-detector current and with a mirror transistor one of the pair of transistors mirroring the photo-detector current with a mirror current. The first non-linear isolation element has at least two terminals a first of which couples to the collector of the mirror transistor. The first non-linear isolation element exhibits a non-linear voltage drop between the at least two terminals in response to varying levels of the mirror current to improve compliance between the mirror current and the detector current. Methods and means for monitoring a photo-detector are also disclosed.Type: GrantFiled: July 30, 2002Date of Patent: August 16, 2005Assignee: Finisar CorporationInventors: Darin James Douma, Philip D. Shapiro, Linda Xiaorong Liu