Patents by Inventor Xiaorong Liu

Xiaorong Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9770432
    Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: September 26, 2017
    Assignee: Guangzhou Institutes of Biomedicine And Health, Chinese Academy of Sciences
    Inventors: Yanmei Zhang, John Jeffrey Talley, Mark G. Obukowicz, Zhengchao Tu, Micky Tortorella, Yican Wang, Jianqi Liu, Yan Chen, Xiaorong Liu, Xin Lu
  • Patent number: 9763914
    Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: September 19, 2017
    Assignee: Guangzhou Institutes of Biomedicine And Health, Chinese Academy of Sciences
    Inventors: Yanmei Zhang, John Jeffrey Talley, Mark G. Obukowicz, Zhengchao Tu, Micky Tortorella, Yican Wang, Jianqi Liu, Yan Chen, Xiaorong Liu, Xin Lu
  • Publication number: 20170020843
    Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.
    Type: Application
    Filed: June 14, 2016
    Publication date: January 26, 2017
    Inventors: Yanmei ZHANG, John Jeffrey TALLEY, Mark G. OBUKOWICZ, Zhengchao TU, Micky TORTORELLA, Yican WANG, Jianqi LIU, Yan CHEN, Xiaorong LIU, Xin LU
  • Patent number: 9478364
    Abstract: Carbon-based electrodes such as for incorporation into ultracapacitors or other high power density energy storage devices, include activated carbon, carbon black, binder and at least one molecular sieve material. The molecular sieve component can adsorb and trap water, which can facilitate the use of the device at higher voltage, such as greater than 3V. The molecular sieve material may be incorporated into the carbon-based electrodes or formed as a layer over a carbon-based electrode surface.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: October 25, 2016
    Assignee: Corning Incorporated
    Inventors: Kishor Purushottam Gadkaree, Atul Kumar, Xiaorong Liu
  • Publication number: 20160287556
    Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.
    Type: Application
    Filed: June 14, 2016
    Publication date: October 6, 2016
    Inventors: Yanmei ZHANG, John Jeffrey TALLEY, Mark G. OBUKOWICZ, Zhengchao TU, Micky TORTORELLA, Yican WANG, Jianqi LIU, Yan CHEN, Xiaorong LIU, Xin LU
  • Patent number: 9371305
    Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: June 21, 2016
    Assignee: Guangzhou Institutes of Biomedicine And Health, Chinese Academy of Sciences
    Inventors: Yanmei Zhang, John Jeffrey Talley, Mark G. Obukowicz, Zhengchao Tu, Micky Tortorella, Yican Wang, Jianqi Liu, Yan Chen, Xiaorong Liu, Xin Lu
  • Patent number: 9183994
    Abstract: A lithium-ion capacitor may include a cathode, an anode, a separator disposed between the cathode and the anode, a lithium composite material, and an electrolyte solution. The cathode and anode may be non-porous. The lithium composite material comprises a core of lithium metal and a coating of a complex lithium salt that encapsulates the core. In use, the complex lithium salt may dissolve into and constitute a portion of the electrolyte solution.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: November 10, 2015
    Assignee: CORNING INCORPORATED
    Inventors: Kishor Purushottam Gadkaree, Xiaorong Liu
  • Patent number: 9139574
    Abstract: The present invention relates to imidazole, oxazole and thiazole derivatives of tumor-targeted drug combretastatin A4, and phosphate esters, sulfonate esters or pharmaceutically acceptable salts, glycoside derivatives, solvates thereof, wherein the A-ring comprises a 3,5-dimethoxyphenyl group having a substituent at the 4-position. The pharmacological activity assays have demonstrated that the compounds of the present invention have good in vitro anti-tumor activity and excellent tubulin inhibitory effect.
    Type: Grant
    Filed: July 4, 2012
    Date of Patent: September 22, 2015
    Assignee: Nanjing Sanhome Pharmaceutical Co., Ltd.
    Inventors: Yong Wang, Cang Zhang, Xiaorong Liu, Yan Zhang, Yunyun Wang, Wenping Zhang
  • Patent number: 9136064
    Abstract: A method for producing activated carbon includes heating a phenolic novolac resin carbon precursor at a carbonization temperature effective to form a carbon material, and reacting the carbon material with CO2 at an activation temperature effective to form the activated carbon. The resulting activated carbon can be incorporated into a carbon-based electrode of an EDLC. Such EDLC can exhibit a potential window and thus an attendant operating voltage of greater than 3V.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: September 15, 2015
    Assignee: Corning Incorporated
    Inventors: Kishor Purushottam Gadkaree, Andrew Fleitz Husted, Xiaorong Liu
  • Patent number: 9129756
    Abstract: A lithium-ion capacitor includes a cathode, an anode, and a porous separator positioned between the cathode and the anode. The cathode is formed using activated carbon, and the anode is formed from a composite material that includes lithium titanium oxide and a carbon material such as hard carbon or graphite.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: September 8, 2015
    Assignee: Corning Incorporated
    Inventors: Kishor Purushottam Gadkaree, Xiaorong Liu
  • Publication number: 20150228978
    Abstract: A lithium ion battery having a cathode and an anode, the cathode includes a material having an olivine or spinel structure, the anode includes a coating of a composite lithium powder coated with a complex lithium salt, such as LiPF6, LiBF4, LiClO4, LiAsF6, LiF3SO3, and mixtures thereof. A separator is disposed between the anode and the cathode, and a non-aqueous electrolyte solution in contact with the cathode, the anode, and the separator. The anode can include a carbon material. A layer of a composite lithium powder coated with a complex lithium salt can be disposed between the anode and the separator.
    Type: Application
    Filed: February 6, 2015
    Publication date: August 13, 2015
    Inventors: Kishor Purushottam Gadkaree, Xiaorong Liu
  • Publication number: 20150133538
    Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.
    Type: Application
    Filed: August 10, 2012
    Publication date: May 14, 2015
    Applicant: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
    Inventors: Yanmei Zhang, John Jeffrey Talley, Mark G. Obukowicz, Zhengchao Tu, Micky Tortorella, Yican Wang, Jianqi Liu, Yan Chen, Xiaorong Liu, Xin Lu
  • Publication number: 20150055276
    Abstract: Carbon-based electrodes such as for incorporation into ultracapacitors or other high power density energy storage devices, include activated carbon, carbon black, binder and at least one molecular sieve material. The molecular sieve component can adsorb and trap water, which can facilitate the use of the device at higher voltage, such as greater than 3V. The molecular sieve material may be incorporated into the carbon-based electrodes or formed as a layer over a carbon-based electrode surface.
    Type: Application
    Filed: January 28, 2014
    Publication date: February 26, 2015
    Applicant: Corning Incorporated
    Inventors: Kishor Purushottam Gadkaree, Atul Kumar, Xiaorong Liu
  • Publication number: 20150030526
    Abstract: A method for producing activated carbon includes heating a phenolic novolac resin carbon precursor at a carbonization temperature effective to form a carbon material, and reacting the carbon material with CO2 at an activation temperature effective to form the activated carbon. The resulting activated carbon can be incorporated into a carbon-based electrode of an EDLC. Such EDLC can exhibit a potential window and thus an attendant operating voltage of greater than 3V.
    Type: Application
    Filed: January 28, 2014
    Publication date: January 29, 2015
    Applicant: Corning Incorporated
    Inventors: Kishor Purushottam Gadkaree, Andrew Fleitz Husted, Xiaorong Liu
  • Patent number: 8920925
    Abstract: Stabilized lithium particles include a lithium-containing core and a coating of a complex lithium salt that surrounds and encapsulates the core. The coating, which is a barrier to oxygen and water, enables the particles to be handled in the open air and incorporated directly into electrochemical devices. The coating material is compatible, for example, with electrolytic materials that are used in electrochemical cells. The average coated particle size is less than 500 microns.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: December 30, 2014
    Assignee: Corning Incorporated
    Inventors: Kishor Purushottam Gadkaree, Xiaorong Liu
  • Publication number: 20140293507
    Abstract: A lithium-ion capacitor includes a cathode, an anode, and a porous separator positioned between the cathode and the anode. The cathode is formed using activated carbon, and the anode is formed from a composite material that includes lithium titanium oxide and a carbon material such as hard carbon or graphite.
    Type: Application
    Filed: March 28, 2013
    Publication date: October 2, 2014
    Inventors: Kishor Purushottam Gadkaree, Xiaorong Liu
  • Publication number: 20140146440
    Abstract: A lithium-ion capacitor may include a cathode, an anode, a separator disposed between the cathode and the anode, a lithium composite material, and an electrolyte solution. The cathode and anode may be non-porous. The lithium composite material comprises a core of lithium metal and a coating of a complex lithium salt that encapsulates the core. In use, the complex lithium salt may dissolve into and constitute a portion of the electrolyte solution.
    Type: Application
    Filed: November 28, 2012
    Publication date: May 29, 2014
    Inventors: Kishor Purushottam Gadkaree, Xiaorong Liu
  • Publication number: 20140134438
    Abstract: Stabilized lithium particles include a lithium-containing core and a coating of a complex lithium salt that surrounds and encapsulates the core. The coating, which is a barrier to oxygen and water, enables the particles to be handled in the open air and incorporated directly into electrochemical devices. The coating material is compatible, for example, with electrolytic materials that are used in electrochemical cells. The average coated particle size is less than 500 microns.
    Type: Application
    Filed: November 9, 2012
    Publication date: May 15, 2014
    Applicant: CORNING INCORPORATED
    Inventors: Kishor Purushottam Gadkaree, Xiaorong Liu
  • Publication number: 20140128384
    Abstract: The present invention relates to imidazole, oxazole and thiazole derivatives of tumor-targeted drug combretastatin A4, and phosphate esters, sulfonate esters or pharmaceutically acceptable salts, glycoside derivatives, solvates thereof, wherein the A-ring comprises a 3,5-dimethoxyphenyl group having a substituent at the 4-position. The pharmacological activity assays have demonstrated that the compounds of the present invention have good in vitro anti-tumor activity and excellent tubulin inhibitory effect.
    Type: Application
    Filed: July 4, 2012
    Publication date: May 8, 2014
    Applicant: NANJING SANHOME PHARMACEUTICAL CO., LTD.
    Inventors: Yong Wang, Cang Zhang, Xiaorong Liu, Yan Zhang, Yunyun Wang, Wenping Zhang
  • Patent number: 6930300
    Abstract: The method and apparatus for monitoring a photo-detector generates a highly compliant mirror current across a broad range of photo-detector current levels. The apparatus for monitoring includes: a pair of bipolar transistors and a first non-linear isolation element. The pair of transistors are connected in a mirror configuration with a sense transistor one of the pair of transistors sensing a photo-detector current and with a mirror transistor one of the pair of transistors mirroring the photo-detector current with a mirror current. The first non-linear isolation element has at least two terminals a first of which couples to the collector of the mirror transistor. The first non-linear isolation element exhibits a non-linear voltage drop between the at least two terminals in response to varying levels of the mirror current to improve compliance between the mirror current and the detector current. Methods and means for monitoring a photo-detector are also disclosed.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: August 16, 2005
    Assignee: Finisar Corporation
    Inventors: Darin James Douma, Philip D. Shapiro, Linda Xiaorong Liu