Patents by Inventor Xiaoru Chen

Xiaoru Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150212099
    Abstract: This invention generally relates to the field of vitamin D detection. In particular, the invention provides novel methods and kits for assaying a vitamin D moiety in a sample such as a biological fluid.
    Type: Application
    Filed: January 30, 2014
    Publication date: July 30, 2015
    Inventors: Chong-Sheng YUAN, Fakhri Ben Habib SAIDA, Xiaoru CHEN, Chao DOU
  • Publication number: 20150168375
    Abstract: Provided are methods of culturing cancer stem cells in vitro, where the cancer stem cells have been obtained from the peripheral blood of a patient, and methods of using the cultured cancer stem cells in a xenograft model of cancer and for in vivo and in vitro screening of test compounds. Also provided is an enriched population of cancer stem cells obtained from the peripheral blood of a patient.
    Type: Application
    Filed: March 12, 2013
    Publication date: June 18, 2015
    Applicant: MEDIMMUNE, LLC
    Inventors: Haifeng Bao, Xiaoru Chen, Patricia Burke, Xiaoqing Shi, Sanjoo Jalla
  • Publication number: 20140370501
    Abstract: The present invention provides novel methods for determining the presence or amount of a hydrolytic enzyme in a sample, based on novel substrates for the enzymes, and also provides compositions and methods that provide highly sensitive assay methods for such hydrolytic enzymes.
    Type: Application
    Filed: June 19, 2014
    Publication date: December 18, 2014
    Inventors: Chong-Sheng YUAN, Xiaoru CHEN
  • Publication number: 20140329241
    Abstract: The present invention provides novel methods for determining the presence or amount of a hydrolytic enzyme in a sample, based on novel substrates for the enzymes, and also provides compositions and methods that provide highly sensitive assay methods for such hydrolytic enzymes.
    Type: Application
    Filed: July 21, 2014
    Publication date: November 6, 2014
    Inventors: Chong-Sheng Yuan, Xiaoru Chen
  • Patent number: 8795979
    Abstract: The present invention provides novel methods for determining the presence or amount of a hydrolytic enzyme in a sample, based on novel substrates for the enzymes, and also provides compositions and methods that provide highly sensitive assay methods for such hydrolytic enzymes.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: August 5, 2014
    Assignee: General Atomics
    Inventors: Chong-Sheng Yuan, Xiaoru Chen
  • Publication number: 20140162294
    Abstract: The present invention provides methods for assaying a vitamin D moiety in a sample, using a water miscible organic solvent, a specific binding partner that specifically binds to said vitamin D moiety, the binding partner being different from a natural vitamin D binding protein for the vitamin D moiety, and a water soluble polymer that facilitates binding between the specific binding partner and the vitamin D moiety. Kits and reaction mixtures for assaying a vitamin D moiety in a sample are also provided.
    Type: Application
    Filed: December 6, 2012
    Publication date: June 12, 2014
    Applicant: General Atomics
    Inventors: Chong-Sheng Yuan, Xiaoru Chen, Ruffy Baldemeca
  • Publication number: 20120190013
    Abstract: The present invention provides novel methods for determining the presence or amount of a hydrolytic enzyme in a sample, based on novel substrates for the enzymes, and also provides compositions and methods that provide highly sensitive assay methods for such hydrolytic enzymes.
    Type: Application
    Filed: January 17, 2012
    Publication date: July 26, 2012
    Inventors: Chong-Sheng Yuan, Xiaoru Chen
  • Publication number: 20110256155
    Abstract: The invention relates to a rapid, sensitive method to obtain a gene expression profile from a target cell population in a blood sample. The target cells can be circulating tumor cells. Disclosed are methods and kits for obtaining such profiles.
    Type: Application
    Filed: April 18, 2011
    Publication date: October 20, 2011
    Applicant: MEDIMMUNE, LLC
    Inventors: Jiaqi Huang, Haifeng Bao, Philip Brohawn, Patricia Burke, Xiaoru Chen, Theresa Lavallee, Yihong Yao
  • Patent number: 6861103
    Abstract: Nitroxide mediated free radical polymerization of vaporized vinyl monomers, including acrylic acid (AAc), styrene (St), N-2-(hydroxypropyl)methacrylamide (HPMA) and N-isopropyl acrylamide (NIPAAm), on silicon wafers is demonstrated. FTIR, ellipsometry and contact angle goniometry were used to characterize the chemical structures, thickness and hydrophilicity of the films. The growth of film is linearly proportional to its reaction time, leading to the easy and exact control of polymer film thickness from nanometers to submicrons. The capability of polymerizing various monomers allows us to fabricate various functional polymer brushes. The reversible thermo-responsiveness of a 200 nm thick grafted poly(NIPAAm) film in aqueous solution is demonstrated with over 50% change in thickness at its lower critical solution temperature. A tri-block copolymer of poly(AAc)-b-polySt-b-poly(HPMA) is successfully synthesized, proving the renewability of TEMPO-mediated polymerization at vapor phase.
    Type: Grant
    Filed: February 7, 2003
    Date of Patent: March 1, 2005
    Assignee: The Regents of the University of California
    Inventors: Ying Chih Chang, Jun Li, Xiaoru Chen
  • Publication number: 20030219535
    Abstract: Nitroxide mediated free radical polymerization of vaporized vinyl monomers, including acrylic acid (AAc), styrene (St), N-2-(hydroxypropyl) methacrylamide (HPMA) and N-isopropyl acrylamide (NIPAAm), on silicon wafers is demonstrated. FTIR, ellipsometry and contact angle goniometry were used to characterize the chemical structures, thickness and hydrophilicity of the films. The growth of film is linearly proportional to its reaction time, leading to the easy and exact control of polymer film thickness from nanometers to submicrons. The capability of polymerizing various monomers allows us to fabricate various functional polymer brushes. The reversible thermo-responsiveness of a 200 nm thick grafted poly(NIPAAm) film in aqueous solution is demonstrated with over 50% change in thickness at its lower critical solution temperature. A tri-block copolymer of poly(AAc)-b-polySt-b-poly(HPMA) is successfully synthesized, proving the renewability of TEMPO-mediated polymerization at vapor phase.
    Type: Application
    Filed: February 7, 2003
    Publication date: November 27, 2003
    Inventors: Ying Chih Chang, Jun Li, Xiaoru Chen
  • Patent number: 6156346
    Abstract: A delivery system that releases a diagnostic marker or therapeutic agent in a manner sensitive to the concentration of urease in a physiological compartment, particularly the gastrointestinal tract, and methods of use.
    Type: Grant
    Filed: January 29, 1998
    Date of Patent: December 5, 2000
    Assignee: Johns Hopkins University
    Inventors: Xiaoru Chen, P. Jay Pasricha, Kam W. Leong