Patents by Inventor Xiaoru SHAO

Xiaoru SHAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid aptamer AS1411 modified DNA tetrahedron and preparation method thereof
    Patent number: 10563205
    Abstract: This invention discloses a nucleic acid aptamer AS1411 modified DNA tetrahedron. The preparation method includes the steps of (1) binding an AS1411 sequence to the 5? terminal of any DNA single-strand in a DNA tetrahedron, synthesizing the DNA, dissolving obtained DNA powder with ddH2O; (2) measuring an absorbance of the DNA and then calculating a total volume of the four single strands; (3) pipetting the DNA obtained in step (1) according to the calculation results in step (2), mixing the DNA with a TM buffer, mixing the mixture uniformly with vortex vibration, and performing a PCR progress. The preparation method is simple. The produced product can effectively solve the problem that the unmodified DNA tetrahedron cannot enter the nucleus and the problem that the AS1411 cannot carry drugs directly.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: February 18, 2020
    Assignee: SICHUAN UNIVERSITY
    Inventors: Yunfeng Lin, Qianshun Li, Xiaoxiao Cai, Shiyu Lin, Xiaoru Shao
  • NUCLEIC ACID APTAMER AS1411 MODIFIED DNA TETRAHEDRON AND PREPARATION METHOD THEREOF
    Publication number: 20190048347
    Abstract: This invention discloses a nucleic acid aptamer AS1411 modified DNA tetrahedron. The preparation method includes the steps of (1) binding an AS1411 sequence to the 5? terminal of any DNA single-strand in a DNA tetrahedron, synthesizing the DNA, dissolving obtained DNA powder with ddH2O; (2) measuring an absorbance of the DNA and then calculating a total volume of the four single strands; (3) pipetting the DNA obtained in step (1) according to the calculation results in step (2), mixing the DNA with a TM buffer, mixing the mixture uniformly with vortex vibration, and performing a PCR progress. The preparation method is simple. The produced product can effectively solve the problem that the unmodified DNA tetrahedron cannot enter the nucleus and the problem that the AS1411 cannot carry drugs directly.
    Type: Application
    Filed: November 30, 2016
    Publication date: February 14, 2019
    Applicant: Sichuan University
    Inventors: Yunfeng LIN, Qianshun LI, Xiaoxiao CAI, Shiyu LIN, Xiaoru SHAO