Abstract: The present invention discloses novel proinsulin glargine and method for for preparing insulin glargine therefrom. A sequence of the proinsulin glargine containing SOD fusion peptide subjected to site-directed mutagenesis and “0 C peptide” is designed; recombinant Escherichia coli for expressing insulin glargine are constructed; insulin glargine fusion protein in a form of an inclusion body is expressed; and denaturation, renaturation, modification, enzyme digestion, separation and purification are carried out to obtain a mature insulin glargine active pharmaceutical ingredient. According to the present invention, the SOD fusion peptide sequence is mutated to enhance the fermentation yield of the insulin glargine by 75%; and a “0 C peptide” strategy is adopted to reduce the quality loss and miscleavage impurities in the enzyme digestion transformation. The purity of the insulin glargine active pharmaceutical ingredient prepared in the present invention is up to 99.

Abstract: An optical cage assembly includes a box-like housing, a radiator, and a cover-like fastener. The box-like housing has a slot. A first housing wall of the box-like housing has an opening at a position close to a slot opening of the slot. The radiator is located at the opening and can be bonded to an electrical connector plugged into the slot. The cover-like fastener is fastened to housing walls of the box-like housing, and the cover-like fastener has a memory alloy member, where the memory alloy member is located on a surface that is of the radiator and that is away from the opening. In this disclosure, easy plugging and unplugging of an optical module in the slot can be implemented, heat transfer between the radiator and the optical module can be accelerated, and an effect of heat dissipation for the optical module can be enhanced.

Abstract: The present invention discloses a method for lowering an oil pipe in a gas well without well-killing, a soluble bridge plug and a material preparation method thereof, wherein, the method comprises the steps of: lowering a bridge plug in a wellbore such that the bridge plug blocks the wellbore at a predetermined location in the wellbore; injecting water in the wellbore after the pressure in the wellbore has been relieved so as to replace gases in the wellbore; and lowering an oil pipe in the wellbore to the location of the bridge plug. The method for lowering an oil pipe in a gas well without well-killing, the soluble bridge plug and the material preparation method thereof provided in the present invention successfully solve the problem of high cost for lowering an oil pipe under pressure after a fracturing fluid has been injected into the casing.

Abstract: Provided in the present invention are a novel pro-insulin aspart structure design and a method for preparing insulin aspart. The main steps comprise designing the pro-insulin aspart sequence, constructing recombinant insulin aspart engineered bacteria, inducing an insulin fusion protein expressed in the form of an inclusion body by means of the engineered bacteria, and obtaining a mature insulin aspart material drug by means of denaturing, renaturing enzymatic digestion, and separation purification, By means of changing the recombinant leading peptide and C-peptice sequences, the invention avoids the dangerous and tedious step of cleavage using cyanogen bromide. The C-peptide is shortened to one amino acid, reducing the quality loss of enzymatic digestion conversion.

Abstract: Provided are a management and control method for applications, a terminal, and a storage medium. The method includes: determining, according to a broadcast message received from an operating system, an identifier of a broadcast receiver corresponding to an identifier of the broadcast message; screening out at least one broadcast receiver declared by an application which has an identifier the same as the identifier of the broadcast receiver corresponding to the identifier of the broadcast message; and transmitting the broadcast message to a broadcast receiver in a reception-enabled state among the at least one broadcast receiver declared by the application, and performing management and control on the application corresponding to the broadcast receiver in the reception-enabled state.

Abstract: The invention belongs to the technical field of polypeptide preparation methods, and in particular relates to a preparation method of a liraglutide intermediate polypeptide GLP-1 (7-37). In the preparation method, main steps include constructing recombinant liraglutide engineered bacteria via E. coli to induce expression of a liraglutide intermediate fusion protein in the form of inclusion bodies, and performing denaturation, renaturation, enzyme digestion, separation and purification to obtain the liraglutide intermediate polypeptide GLP-1 (7-37). The invention alters expression pattern into the expression of the intracellular insoluble inclusion bodies by changing a signal peptide of the recombinant sequence to increase significantly expression level. The liraglutide intermediate polypeptide prepared by the invention has a purity up to 87% or more and a yield of more than 85%.

Abstract: The present invention discloses a method for lowering an oil pipe in a gas well without well-killing, a soluble bridge plug and a material preparation method thereof, wherein, the method comprises the steps of: lowering a bridge plug in a wellbore such that the bridge plug blocks the wellbore at a predetermined location in the wellbore; injecting water in the wellbore after the pressure in the wellbore has been relieved so as to replace gases in the wellbore; and lowering an oil pipe in the wellbore to the location of the bridge plug. The method for lowering an oil pipe in a gas well without well-killing, the soluble bridge plug and the material preparation method thereof provided in the present invention successfully solve the problem of high cost for lowering an oil pipe under pressure after a fracturing fluid has been injected into the casing.

Abstract: The invention belongs to the technical field of polypeptide preparation methods, and in particular relates to a preparation method of a liraglutide intermediate polypeptide GLP-1 (7-37). In the preparation method, main steps include constructing recombinant liraglutide engineered bacteria via E. coli to induce expression of a liraglutide intermediate fusion protein in the form of inclusion bodies, and performing denaturation, renaturation, enzyme digestion, separation and purification to obtain the liraglutide intermediate polypeptide GLP-1 (7-37). The invention alters expression pattern into the expression of the intracellular insoluble inclusion bodies by changing a signal peptide of the recombinant sequence to increase significantly expression level. The liraglutide intermediate polypeptide prepared by the invention has a purity up to 87% or more and a yield of more than 85%.

Abstract: Embodiments of the present disclosure provide a die casting aluminum alloy, including constituents with the following mass percentages: silicon: 4.0% to 10.0%; magnesium: 0.2% to 1.0%; copper: ?0.1%; manganese: ?0.1%; zinc: ?0.1%; ferrum: ?1.3%; titanium: ?0.2%; inevitable impurities: ?0.15%; and the rest: aluminum. The die casting aluminum alloy has a high heat-conducting property, good formability, high corrosion resistance, and a good mechanical property. This can resolve a prior-art problem that forming and heat dissipation requirements of a communications product with a complex structure, high heat flux density, and large power cannot be met at the same time because it is difficult for a die casting aluminum alloy to have both a high heat-conducting property and good formability. The embodiments of the present disclosure further provide a production method of the die casting aluminum alloy and a communications product.

Abstract: The embodiments of disclosure provide a method and device for loading a system Application (APP) installation package, and a terminal. The method includes that: before update processing of a system APP installation package, the system APP installation package is renamed as a system APP installation backup package; whether loading according to a system APP installation update package is successful is judged, wherein the system APP installation update package is the system APP installation package acquired after updating a copied version formed by copying the system APP installation backup package; and in a case that a judging result is that loading according to the system APP installation update package is not successful, loading is performed according to the system APP installation backup package, thereby achieving the effect of improving system stability and user experience.

Abstract: The present disclosure provides a dynamic path linking method and device, and a mobile terminal. The method includes that: responding to a request for invoking the path of the primary memory, it is detected whether an external storage card exists; and the path of the primary memory is dynamically set to be a storage path of the external storage card or a storage path of an internal storage card according to a detection result. The present disclosure solves the problem that the path of the primary memory cannot be dynamically linked, thereby achieving an effect of improving user experience.