Patents by Inventor Xiaosa Li

Xiaosa Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fusion proteins for improved precision in base editing
    Patent number: 12203077
    Abstract: Provided are base editors containing a cytidine and a catalytically inactive version of Lachnospiraceae bacterium Cpf1 (LbCpf1). The new base editors have greatly improved editing efficiency and fidelity as compared to Cas9-based base editors, and have different editing windows.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: January 21, 2025
    Assignee: ShanghaiTech University
    Inventors: Jia Chen, Xingxu Huang, Li Yang, Bei Yang, Xiaosa Li, Ying Wang, Yajing Liu
  • GENOMIC EDITING OF IMPROVED EFFICIENCY AND ACCURACY
    Publication number: 20230399641
    Abstract: Provided are compositions and methods for enhanced prime editing, which include a pegRNA that encodes a target mutation in a target protein, along with one or more nearby silent or conservative mutations. These silent mutations can increase the editing efficiency, without causing a change to the target protein sequence. Also provided are compositions and methods of using the improved prime editing for preventing or treating infections by SARS-CoV or SARS-CoV-2.
    Type: Application
    Filed: November 11, 2021
    Publication date: December 14, 2023
    Inventors: Jia CHEN, Bei YANG, Li YANG, Xiaosa LI, Xiao WANG, Wenwen ZHAO, Lina ZHOU, Jifang LI
  • FUSION PROTEINS FOR IMPROVED PRECISION IN BASE EDITING
    Publication number: 20200354729
    Abstract: Provided are base editors containing a cytidine and a catalytically inactive version of Lachnospiraceae bacterium Cpf1 (LbCpf1). The new base editors have greatly improved editing efficiency and fidelity as compared to Cas9-based base editors, and have different editing windows.
    Type: Application
    Filed: August 28, 2018
    Publication date: November 12, 2020
    Inventors: Jia Chen, Xingxu Huang, Li Yang, Bei Yang, Xiaosa Li, Ying Wang, Yajing Liu