Abstract: Provided are a robot calibration method and apparatus, an electronic device and a storage medium. The method comprises: establishing an i-th kinematic model between a first coordinate system of an i-th calibration block and a second coordinate system of a detection end of a robot, wherein i is a positive integer greater than or equal to 1 and less than or equal to n, and n is the number of calibration blocks; determining a plurality of pieces of pose data of the detection end in contact with a plurality of test points on the i-th calibration block; determining a plurality of contact coordinates of the detection end according to the plurality of pieces of pose data and the i-th kinematic model; and determining a measurement parameter of the robot according to n groups of contact coordinates corresponding to the n calibration blocks.

Abstract: Disclosed are a coagulation factor VIII fusion protein which is conjugated with polyalkylene glycol and which has an extended cyclic half-life, a preparation method therefor and a use thereof, wherein the active moiety of the coagulation factor VIII is directly linked or indirectly linked by a peptide linker to a fusion partner, and the fusion protein is further conjugated to a polyalkylene glycol. The half-life is significantly increased compared to an FVIII fusion protein modified without polyalkylene glycol.

Abstract: Provided are a construction method and a sequencing method for a single-cell transcriptome sequencing library and a test kit for preparing a single-cell transcriptome library. In the method, a single-cell suspension is subjected to in-situ reverse transcription in a cell or a cell nucleus, the cell or the cell nucleus, together with a magnetic bead, is overloaded into a droplet for a droplet PCR reaction, and then the magnetic bead is recovered and subjected to secondary amplification, fragmentation and library construction, such that the single-cell transcriptome sequencing library is obtained. According to the method, overloading of the cell or cell nucleus subjected to the in-situ reverse transcription together with the pretreated magnetic bead is achieved, an ultra-high throughput of 100,000 cells in a single experiment is obtained, and quite high accuracy is exhibited.

Abstract: Systems and methods are provided for dynamic segmentation of users during an experiment based on changes to application data collected during the experiment. Data regarding application interactions and associated application metadata may be collected from users during application experiments that involve testing different variants of a feature or otherwise different user experiences. The data regarding application interactions and associated application metadata may be evaluated to discover segments of users and/or usage patterns (e.g., “cohorts”). During the experiment, the users may be dynamically re-segmented into new/different cohorts based on new application data being collected.

Abstract: A calculation system for predicting a proppant embedding depth based on a shale softening effect is provided, including a sampling test terminal, a scheduling module, a monitoring module, and a calculation module, wherein the scheduling module, the monitoring module, and the calculation module are connected in communication, and the monitoring module is connected to an external operating system through a wireless network, wherein the external operating system is configured to perform a hydraulic fracturing operation and receive a first control signal and/or a second control signal from the monitoring module. The sampling test terminal is configured to test the samples and obtain test data. The scheduling module is configured to determine a target construction parameter.

Abstract: A project disaster warning method and system based on collaborative fusion of multi-physical field monitoring data is provided.

Abstract: The present disclosure relates to a calculation method for predicting a proppant embedding depth based on a shale softening effect, including determining a spontaneous imbibition depth-soaking time curve; determining a Young’s modulus-soaking time curve of core surfaces; establishing a proppant embedding model containing a softened layer by a finite element method; conducting a numerical simulation to obtain an embedding volume-soaking time curve; and obtaining a calculation formula for a proppant embedding volume considering a softening effect.

Abstract: A highly glycosylated human blood-clotting factor VIII (FVIII) fusion protein, and a manufacturing method and application of same. The fusion protein comprises, from the N-terminus to the C-terminus, a human (FVIII), a flexible peptide connector, at least one rigid unit of a human chorionic gonadotropin ?-subunit carboxyl terminal peptide, and a half-life extending portion (preferentially selected from a human IgG Fc variant). The fusion protein has a similar level of biological activity as a recombinant (FVIII) and an extended in vivo half-life, thereby improving pharmacokinetics and drug efficacy.

Abstract: Provided by the present invention are a novel GLP-1 fusion protein and a conjugate thereof, a pharmaceutical composition containing same, and a use thereof in reducing blood sugar or body weight, especially for treating diabetes, in particular type II diabetes.

Abstract: Disclosed are a coagulation factor VIII fusion protein which is conjugated with polyalkylene glycol and which has an extended cyclic half-life, a preparation method therefor and a use thereof, wherein the active moiety of the coagulation factor VIII is directly linked or indirectly linked by a peptide linker to a fusion partner, and the fusion protein is further conjugated to a polyalkylene glycol. The half-life is significantly increased compared to an FVIII fusion protein modified without polyalkylene glycol.

Abstract: A highly glycosylated human blood-clotting factor VIII (FVIII) fusion protein, and a manufacturing method and application of same. The fusion protein comprises, from the N-terminus to the C-terminus, a human (FVIII), a flexible peptide connector, at least one rigid unit of a human chorionic gonadotropin ?-subunit carboxyl terminal peptide, and a half-life extending portion (preferentially selected from a human IgG Fc variant). The fusion protein has a similar level of biological activity as a recombinant (FVIII) and an extended in vivo half-life, thereby improving pharmacokinetics and drug efficacy.

Abstract: A method of gasifying carbonaceous material is described. The method comprises a first step of pyrolyzing and partially gasifying the carbonaceous material to produce volatiles and char. The volatiles and the char are then separated and, subsequently, the char is gasified and the volatiles are reformed. The raw product gas is then finally cleaned with char or char-supported catalysts or other catalysts.

Abstract: A pyrolysis plant 20 comprises a grinding pyrolyzer 22, being a machine or apparatus in which both particle size reduction and pyrolysis occur simultaneously. Plant 20 also comprises a bin (hopper) 30 for holding wet particulate biomass feedstock. Chute 32 leads from the bin 30 to a biomass dryer 34 which reduces moisture content of the feedstock as low as possible, e.g., to below about 10. Dried feedstock is conveyed from dryer 34 via line 36 to a dried biomass feedstock hopper 38. Dried feedstock is fed from hopper 38 into a chute 40 which leads to an inlet trunnion 42 of grinding pyrolyzer 22. A discharge trunnion 44 of grinding pyrolyzer 22 leads to a char holder 60 for collecting char particles and a condensation train 62 for condensing vapor generated by the pyrolysis to produce oil.

Abstract: A method for preparing low-cost clean steel includes steps of: preliminarily desulfurizing iron melt: preliminarily desulfurizing in an iron melt channel during blast furnace tapping and during iron folding in an iron folding room, adding a desulfurizing ball into the iron melt during the blast furnace tapping or the iron folding; dephosphorizing and controlling sulfur: dephosphorizing and controlling sulfur during converter steelmaking, in such a manner that P?0.014% and S?0.004% during tapping; rapidly dephosphorizing by slag-forming: rapidly dephosphorizing by slag-forming during converter tapping, at a converter end point, controlling a C content at 0.02˜0.10%, adding a dephosphorizing ball through an alloy chute during the converter tapping, blowing argon and stirring at the same time; purifying steel melt during RH refining: adding a purifying ball at a late stage of the RH refining when a vacuum degree is at 66.7˜500 Pa; and continuously casting with whole-process protection.

Abstract: Various techniques and solutions are described for rule-based access to removable storage devices. For example, a request can be received to perform a file system operation using a removable storage device that is formatted with a file system that does not support access controls. A rules-based check of the received request can be performed by a service by checking the request against a plurality of rules. Based on results of the rules-based check, the request can be allowed or denied.

Abstract: A method of gasifying carbonaceous material is described. The method comprises a first step of pyrolysing and partially gasifying the carbonaceous material to produce volatiles and char. The volatiles and the char are then separated and, subsequently, the char is gasified and the volatiles are reformed. The raw product gas is then finally cleaned with char or char-supported catalysts or other catalysts.