Abstract: A calculation system for predicting a proppant embedding depth based on a shale softening effect is provided, including a sampling test terminal, a scheduling module, a monitoring module, and a calculation module, wherein the scheduling module, the monitoring module, and the calculation module are connected in communication, and the monitoring module is connected to an external operating system through a wireless network, wherein the external operating system is configured to perform a hydraulic fracturing operation and receive a first control signal and/or a second control signal from the monitoring module. The sampling test terminal is configured to test the samples and obtain test data. The scheduling module is configured to determine a target construction parameter.

Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.

Abstract: The technology of this application relates to a frontlight module and a display apparatus. The frontlight module is disposed on a side of a display panel. The frontlight module includes a light source, a light guide plate, and light guide dots. The light guide plate includes a first surface and a second surface that are disposed opposite to each other. The display panel is disposed facing the second surface. The light source is disposed on a side surface of the light guide plate. A plurality of light guide dots are disposed on the first surface or the second surface of the light guide plate. Each light guide dot has a light guide surface disposed at an angle with respect to a surface of the light guide plate. Light is fully reflected and/or refracted on the light guide surfaces to propagate to the display panel.

Abstract: A project disaster warning method and system based on collaborative fusion of multi-physical field monitoring data is provided.

Abstract: The present disclosure relates to a calculation method for predicting a proppant embedding depth based on a shale softening effect, including determining a spontaneous imbibition depth-soaking time curve; determining a Young’s modulus-soaking time curve of core surfaces; establishing a proppant embedding model containing a softened layer by a finite element method; conducting a numerical simulation to obtain an embedding volume-soaking time curve; and obtaining a calculation formula for a proppant embedding volume considering a softening effect.

Abstract: A highly glycosylated human blood-clotting factor VIII (FVIII) fusion protein, and a manufacturing method and application of same. The fusion protein comprises, from the N-terminus to the C-terminus, a human (FVIII), a flexible peptide connector, at least one rigid unit of a human chorionic gonadotropin ?-subunit carboxyl terminal peptide, and a half-life extending portion (preferentially selected from a human IgG Fc variant). The fusion protein has a similar level of biological activity as a recombinant (FVIII) and an extended in vivo half-life, thereby improving pharmacokinetics and drug efficacy.

Abstract: Provided by the present invention are a novel GLP-1 fusion protein and a conjugate thereof, a pharmaceutical composition containing same, and a use thereof in reducing blood sugar or body weight, especially for treating diabetes, in particular type II diabetes.

Abstract: Disclosed are a coagulation factor VIII fusion protein which is conjugated with polyalkylene glycol and which has an extended cyclic half-life, a preparation method therefor and a use thereof, wherein the active moiety of the coagulation factor VIII is directly linked or indirectly linked by a peptide linker to a fusion partner, and the fusion protein is further conjugated to a polyalkylene glycol. The half-life is significantly increased compared to an FVIII fusion protein modified without polyalkylene glycol.

Abstract: A highly glycosylated human blood-clotting factor VIII (FVIII) fusion protein, and a manufacturing method and application of same. The fusion protein comprises, from the N-terminus to the C-terminus, a human (FVIII), a flexible peptide connector, at least one rigid unit of a human chorionic gonadotropin ?-subunit carboxyl terminal peptide, and a half-life extending portion (preferentially selected from a human IgG Fc variant). The fusion protein has a similar level of biological activity as a recombinant (FVIII) and an extended in vivo half-life, thereby improving pharmacokinetics and drug efficacy.

Abstract: A method of gasifying carbonaceous material is described. The method comprises a first step of pyrolyzing and partially gasifying the carbonaceous material to produce volatiles and char. The volatiles and the char are then separated and, subsequently, the char is gasified and the volatiles are reformed. The raw product gas is then finally cleaned with char or char-supported catalysts or other catalysts.

Abstract: A pyrolysis plant 20 comprises a grinding pyrolyzer 22, being a machine or apparatus in which both particle size reduction and pyrolysis occur simultaneously. Plant 20 also comprises a bin (hopper) 30 for holding wet particulate biomass feedstock. Chute 32 leads from the bin 30 to a biomass dryer 34 which reduces moisture content of the feedstock as low as possible, e.g., to below about 10. Dried feedstock is conveyed from dryer 34 via line 36 to a dried biomass feedstock hopper 38. Dried feedstock is fed from hopper 38 into a chute 40 which leads to an inlet trunnion 42 of grinding pyrolyzer 22. A discharge trunnion 44 of grinding pyrolyzer 22 leads to a char holder 60 for collecting char particles and a condensation train 62 for condensing vapor generated by the pyrolysis to produce oil.

Abstract: A method for preparing low-cost clean steel includes steps of: preliminarily desulfurizing iron melt: preliminarily desulfurizing in an iron melt channel during blast furnace tapping and during iron folding in an iron folding room, adding a desulfurizing ball into the iron melt during the blast furnace tapping or the iron folding; dephosphorizing and controlling sulfur: dephosphorizing and controlling sulfur during converter steelmaking, in such a manner that P?0.014% and S?0.004% during tapping; rapidly dephosphorizing by slag-forming: rapidly dephosphorizing by slag-forming during converter tapping, at a converter end point, controlling a C content at 0.02˜0.10%, adding a dephosphorizing ball through an alloy chute during the converter tapping, blowing argon and stirring at the same time; purifying steel melt during RH refining: adding a purifying ball at a late stage of the RH refining when a vacuum degree is at 66.7˜500 Pa; and continuously casting with whole-process protection.

Abstract: Various techniques and solutions are described for rule-based access to removable storage devices. For example, a request can be received to perform a file system operation using a removable storage device that is formatted with a file system that does not support access controls. A rules-based check of the received request can be performed by a service by checking the request against a plurality of rules. Based on results of the rules-based check, the request can be allowed or denied.

Abstract: A method of gasifying carbonaceous material is described. The method comprises a first step of pyrolysing and partially gasifying the carbonaceous material to produce volatiles and char. The volatiles and the char are then separated and, subsequently, the char is gasified and the volatiles are reformed. The raw product gas is then finally cleaned with char or char-supported catalysts or other catalysts.

Abstract: Various techniques and solutions are described for rule-based access to removable storage devices. For example, a request can be received to perform a file system operation using a removable storage device that is formatted with a file system that does not support access controls. A rules-based check of the received request can be performed by a service by checking the request against a plurality of rules. Based on results of the rules-based check, the request can be allowed or denied.

Abstract: A method of gasifying carbonaceous material is described. The method comprises a first step of pyrolysing and partially gasifying the carbonaceous material to produce volatiles and char. The volatiles and the char are then separated and, subsequently, the char is gasified and the volatiles are reformed. The raw product gas is then finally cleaned with char or char-supported catalysts or other catalysts.

Abstract: A pyrolysis plant 20 comprises a grinding pyrolyser 22, being a machine or apparatus in which both particle size reduction and pyrolysis occur simultaneously. Plant 20 also comprises a bin (hopper) 30 for holding wet particulate biomass feedstock. Chute 32 leads from the bin 30 to a biomass dryer 34 which reduces moisture content of the feedstock as low as possible, e.g., to below about 10. Dried feedstock is conveyed from dryer 34 via line 36 to a dried biomass feedstock hopper 38. Dried feedstock is fed from hopper 38 into a chute 40 which leads to an inlet trunnion 42 of grinding pyrolyser 22. A discharge trunnion 44 of grinding pyrolyser 22 leads to a char holder 60 for collecting char particles and a condensation train 62 for condensing vapour generated by the pyrolysis to produce oil.