Abstract: Provided herein are Cas proteins and guide RNA molecules engineered to exhibit increased activity in eukaryotic cells. The provided Cas proteins and RNA molecules are particularly useful for applications where modulation of eukaryotic nucleic acids with relatively small molecules is advantageous. Also provided are nucleic acids and vectors encoding the disclosed Cas proteins and guide RNA molecules, pharmaceutical compositions including the Cas proteins and guide RNA molecules, and methods for using the disclosed materials.

Abstract: Fusion constructs encoding RNase-H-like domain containing compositions are disclosed. Disclosed are also compositions and methods utilizing RNase-H-like domain containing compositions for the treatment of cancer. Also disclosed are the methods of making and using the RNase-H-like domain containing compositions in treating various diseases, conditions, and cancer.

Abstract: Fusion constructs encoding RNase-H-like domain containing compositions are disclosed. Disclosed are also compositions and methods utilizing RNase-H-like domain containing compositions for the treatment of cancer. Also disclosed are the methods of making and using the RNase-H-like domain containing compositions in treating various diseases, conditions, and cancer.

Abstract: The present invention provides a method for preparing a high molecular polymer powder material comprising the following steps: adding 20 parts of a high molecular powder material and 0.1 to 10 parts of carbon black into a mixing tank, and performing high-speed stirring for the first time to obtain a high molecular carbon black mixed powder material; adding the high molecular carbon black mixed powder material, 0.1 to 1 part of a flow aid, and 80 parts of a polymer powder material into the powder mixing tank; and performing high-speed stirring for a second time followed by sieving to obtain the high molecular polymer powder material.

Abstract: Fusion constructs encoding RNase-H-like domain containing compositions are disclosed. Disclosed are also compositions and methods utilizing RNase-H-like domain containing compositions for the treatment of cancer. Also disclosed are the methods of making and using the RNase-H-like domain containing compositions in treating various diseases, conditions, and cancer.

Abstract: A biometric based system with advanced security and privacy characteristics for the verification of a person's identity using neural net engine simulation software code and neural net weights obtained from a computer enrollment system and ported into any electronic device with an embedded microprocessor and memory. The neural net structure has both inter and intra layer connections of all nodes.

Abstract: A biometric based system with advanced security and privacy characteristics for the verification of a person's identity using neural net engine simulation software code and neural net weights obtained from a computer enrollment system and ported into any electronic device with an embedded microprocessor and memory. The neural net structure has both inter and intra layer connections of all nodes.

Abstract: A biometric based system with advanced security and privacy characteristics for the verification of a person's identity using embedded neural net structures and associated weights that process input and output data in parallel and require no central processing unit or microcontroller; resulting in low power dissipation, low cost processing chip, and affordable verification solution for portable uses such as financial transaction cards, identification cards, computers, wireless devices, keyless wireless entry systems, and others.

Abstract: An arc welding device apparatus for controlling an arc welder through use of a neural network in real-time. The invention can also record output from an arc welding apparatus, indicating whether penetration has occurred during the welding process, and can also activate an alarm when penetration occurs during the arc welding process.