Patents by Inventor Xiaosong Gu
Xiaosong Gu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240140619Abstract: The present invention discloses a method for autonomous mission planning of Carbon Satellite, which triggers autonomous mission planning for the satellite when it detects the satellite switching from a shadow area to a light area, comprising: determining planning time sequence, wherein the planning time sequence comprise several time nodes; and then, for each time node, carrying out a prediction of the ground attributes of the sub-satellite point, and setting observation arc segment according to the prediction result; and finally, determining the load power-on-off time sequence according to the observation arc segment.Type: ApplicationFiled: July 12, 2021Publication date: May 2, 2024Applicants: INNOVATION ACADEMY FOR MICROSATELLITES OF CAS, SHANGHAI ENGINEERING CENTER FOR MICROSATELLITESInventors: Longfei TIAN, Zengshan YIN, Guohua LIU, Denghui HU, Wenjuan GU, Shuang GAO, Zeying DONG, Xiaosong YAO, Dinghui SHANG
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Patent number: 11788058Abstract: A protein-modified PLGA microsphere can be used to construct tissue-engineered nerve. The microspheres are loaded with active substances for treating peripheral nerve injury and are bound to tissue-engineered nerves. It has been shown that the prepared tissue-engineered nerve effectively promotes nerve regeneration after peripheral nerve injury.Type: GrantFiled: June 19, 2020Date of Patent: October 17, 2023Assignee: NANTONG UNIVERSITYInventors: Xin Tang, Cheng Sun, Xiaosong Gu, Youlang Zhou, Chunkang Tang
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Patent number: 11731098Abstract: Ag—Fe3O4 immunomagnetic microsphere contains poly-D-lysine modified on the surface and S100? and/or MBP antibody linked by an amide bond. The Ag—Fe3O4 immunomagnetic microsphere can specifically capturing peripheral nerve tissue-derived exosomes. When the microsphere is used to extract nerve tissue-derived exosomes, the extraction yield of exosomes per unit volume of nerve tissue is high, and the nerve specificity is strong.Type: GrantFiled: January 15, 2021Date of Patent: August 22, 2023Assignee: NANTONG UNIVERSITYInventors: Xin Tang, Cheng Sun, Xiaokun Gu, Xiaosong Gu, Qianru He, Tianmei Qian, Wenfeng Su, Haoming Li
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Publication number: 20230210936Abstract: A traditional Chinese medicine compound preparation for treating Parkinson's disease and its preparation method and application are disclosed. The traditional Chinese medicine compound preparation comprises traditional Chinese medicine formula components and the traditional Chinese medicine formula components comprise the following raw material or raw material extracts by mass: 6-15 parts of uncaria rhynchophylla, 3-9 parts of gastrodia elata, 6-12 parts of Gentiana macrophylla, 10-20 parts of raw astragalus membranaceus, 10-20 parts of prepared rehmannia roots, 10-20 parts of achyranthes roots, 10-20 parts of wolfberry fruits, 10-20 parts of angelica sinensis, 10-20 parts of fried atractylodes macrocephala, 6-15 parts of fried spina date seeds, 3-12 parts of walnut kernels, 3-9 parts of safflower, and 20-30 parts of zaocys dhumnade.Type: ApplicationFiled: August 5, 2020Publication date: July 6, 2023Applicant: NANTONG UNIVERSITYInventors: Xiaosong GU, Chunkang TANG, Leilei GONG, Xiaomin WANG, Xin TANG
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Publication number: 20230151065Abstract: A multi-disulfide-bond long-chain peptide with neuroprotective activity can reduce cellular calcium influx by inhibiting glutamate receptors to protect cortical neurons from excitotoxicity induced by glutamate. It can be an effective neuroprotective agent.Type: ApplicationFiled: April 10, 2019Publication date: May 18, 2023Inventors: Xiaozhe ZHANG, Fei DING, Qiong CHENG, Xiaosong GU, Xinmiao LIANG, Yunpeng BAI, Dengbing YAO, Ying YUAN, Caiping WANG, Jian YANG, Shu YU
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Publication number: 20230144643Abstract: A silk fibroin nerve graft fused with NT3 and a preparation method therefor is provided. The method includes the steps of: synthesizing a gene fragment containing a silk fibroin light chain and NT-3, connecting the fragment to a pET-30 expression vector, and transferring the obtained recombinant expression vector into BL21 Escherichia coli to obtain a fusion protein; placing a silk fibroin fiber web in a mold, mixing the fusion protein and a silk fibroin solution, and performing freeze drying to enable the silk fibroin to be crosslinked with the fusion protein to form a nerve conduit; and after deformation processing, finally obtaining a silk fibroin nerve graft having NT-3 activity. The silk fibroin nerve graft can provide a mechanical support, exert nerve protection and nerve regeneration promotion functions in a long term, and adjust the proportion of NT-3 bioactive peptides in the nerve conduit, facilitating repair of nerve injuries.Type: ApplicationFiled: July 24, 2020Publication date: May 11, 2023Applicant: NANTONG UNIVERSITYInventors: Yan LIU, Mei LIU, Xiaosong GU, Tuchen GUAN
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Publication number: 20230043437Abstract: Disclosed are a compound preparation for neuranagenesis, and a preparation method therefor and the use thereof. The compound preparation for neuranagenesis comprises the raw medicinal materials in parts by weight: 10-20 parts of raw Astragali radix, 10-20 parts of Rehmaimiae Radix praeparata, 10-20 parts of Actyranthes bidentata, 6-15 parts of Jujubae fructus, 6-15 parts of Lycii fructus, 6-15 parts of parched Ziziphi spinosae semen, 6-12 parts of Angelicae smensis radix, 3-9 parts of Carthami flos, 6-15 parts of Poria, 6-15 parts of parched Atractylodis macrocephalae rhizoma and 10-20 parts of Zaocys. The compound preparation can be used for preparing drugs to treat nerve damage diseases, and can be prepared into oral liquids, granules, dissolved granules and tablets.Type: ApplicationFiled: January 5, 2021Publication date: February 9, 2023Inventors: Xiaosong GU, Chunkang TANG, Fei DING, Xiaoming YANG, Qiong CHENG, Hualin SUN, Lai XU
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Publication number: 20230040479Abstract: A Fructus Forsythiae and Radix Astragali compound preparation, and a preparation method therefor and a use thereof is provided. Traditional Chinese medicine formulation components consist of the following raw materials or raw material extracts in parts by mass: 9-11 parts of Flos Lonicerae, 9-11 parts of Fructus Forsythiae, 9-11 parts of Radix Scutellariae, 9-11 parts of Herba Artemisiae Annuae, 9-11 parts of Radix Astragali, 9-11 parts of stir-fried Rhizoma Atractylodis Macrocephalae, 9-11 parts of Herba Pogostemonis, 5-7 parts of Radix Saposhnikoviae, 9-11 parts of Radix Ophiopogonis, and 5-7 parts of Radix Glycyrrhizae. The components can be made into an oral liquid, a granule, a dissolved medicine, or a tablet. Further disclosed is a use of the Fructus Forsythiae and Radix Astragali compound preparation in preparation of medicines for preventing and/or treating a viral influenza disease.Type: ApplicationFiled: July 14, 2020Publication date: February 9, 2023Applicant: NANTONG UNIVERSITYInventors: Xiaosong GU, Chunkang TANG, Leilei GONG, Yu ZHANG, Qiong CHENG, Xiaoming YANG, Xiaomin WANG
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Publication number: 20220395795Abstract: Ag-Fe3O4 immunomagnetic microsphere contains poly-D-lysine modified on the surface and S100? and/or MBP antibody linked by an amide bond. The Ag-Fe3O4 immunomagnetic microsphere can specifically capturing peripheral nerve tissue-derived exosomes. When the microsphere is used to extract nerve tissue-derived exosomes, the extraction yield of exosomes per unit volume of nerve tissue is high, and the nerve specificity is strong.Type: ApplicationFiled: January 15, 2021Publication date: December 15, 2022Inventors: Xin TANG, Cheng SUN, Xiaokun GU, Xiaosong GU, Qianru HE, Tianmei QIAN, Wenfeng SU, Haoming LI
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Publication number: 20220213437Abstract: A protein-modified PLGA microsphere can be used to construct tissue-engineered nerve. The microspheres are loaded with active substances for treating peripheral nerve injury and are bound to tissue-engineered nerves. It has been shown that the prepared tissue-engineered nerve effectively promotes nerve regeneration after peripheral nerve injury.Type: ApplicationFiled: June 19, 2020Publication date: July 7, 2022Inventors: Xin TANG, Cheng SUN, Xiaosong GU, Youlang ZHOU, Chunkang TANG
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Patent number: 11110202Abstract: A differential tissue-engineered nerve including motor-like nerves and sensory-like nerves. The motor-like nerve and the sensory-like nerve respectively includes a motor-like nerve outer tube and a motor-like nerve fiber in the outer tube as well as a sensory-like nerve outer tube and a sensory-like nerve fiber in the outer tube. Schwann cells and/or fibroblasts derived from motor nerves and sensory nerves are respectively contained in surfaces or pores of the motor-like and sensory-like nerve outer tubes. Transsynaptic signal molecules Neuroligin-1 and Neuroligin-2 are contained in surfaces or pores of the motor-like and sensory-like nerve fibers. Neuroligin-1 is selectively used to specifically promote synaptic remodeling of motor neurons, while Neuroligin-2 is selectively used to specifically promote synaptic remodeling of sensory neurons, so that repair efficiency of motor nerve cells and sensory nerve cells is improved.Type: GrantFiled: September 11, 2019Date of Patent: September 7, 2021Assignee: NANTONG UNIVERSITYInventors: Xin Tang, Cheng Sun, Gang Chen, Xiaosong Gu, Yumin Yang, Fei Ding, Yanpei Gong, Qianru He, Hongkui Wang, Mi Shen
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Publication number: 20210268149Abstract: A differential tissue-engineered nerve including motor-like nerves and sensory-like nerves. The motor-like nerve and the sensory-like nerve respectively includes a motor-like nerve outer tube and a motor-like nerve fiber in the outer tube as well as a sensory-like nerve outer tube and a sensory-like nerve fiber in the outer tube. Schwann cells and/or fibroblasts derived from motor nerves and sensory nerves are respectively contained in surfaces or pores of the motor-like and sensory-like nerve outer tubes. Transsynaptic signal molecules Neuroligin-1 and Neuroligin-2 are contained in surfaces or pores of the motor-like and sensory-like nerve fibers. Neuroligin-1 is selectively used to specifically promote synaptic remodeling of motor neurons, while Neuroligin-2 is selectively used to specifically promote synaptic remodeling of sensory neurons, so that repair efficiency of motor nerve cells and sensory nerve cells is improved.Type: ApplicationFiled: September 11, 2019Publication date: September 2, 2021Inventors: Xin TANG, Cheng SUN, Gang CHEN, Xiaosong GU, Yumin YANG, Fei DING, Yanpei GONG, Qianru HE, Hongkui WANG, Mi SHEN
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Patent number: 10639399Abstract: Provided is a use of one or more MicroRNA genes selected from miRNAs of Family Let-7, miR-21 or miR-222 in the construction of tissue engineered nerves and in the repair of peripheral nerve defects. An outer and/or internal surface or pores of a tissue engineered nerve graft are coated or adsorbed with polymeric nanomicrospheres carrying a Let-7 family miRNA inhibitor, miR-21, or miR-222, or a mimetic thereof, wherein the polymeric material is composed of biocompatible fibronectin and heparin. The regeneration of peripheral nerves and the construction of tissue engineered nerves are promoted by regulating the expression of MicroRNA genes which can effectively promote the proliferation of primary Schwann cells cultured in vitro and have an anti-apoptotic effect on neuronal cells. In-vivo test proves that bridging of the tissue engineered nerve graft can facilitate the regeneration of peripheral nerves, thus being useful in the treatment of peripheral nerve injury.Type: GrantFiled: April 5, 2017Date of Patent: May 5, 2020Assignee: NANTONG UNIVERSITYInventors: Xiaosong Gu, Fei Ding, Xin Tang, Yumin Yang, Bin Yu, Shiying Li, Songlin Zhou, Luzhong Zhang, Yaxian Wang, Yun Gu, Hualin Sun
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Publication number: 20190111179Abstract: Provided is a use of one or more MicroRNA genes selected from miRNAs of Family Let-7, miR-21 or miR-222 in the construction of tissue engineered nerves and in the repair of peripheral nerve defects. An outer and/or internal surface or pores of a tissue engineered nerve graft are coated or adsorbed with polymeric nanomicrospheres carrying a Let-7 family miRNA inhibitor, miR-21, or miR-222, or a mimetic thereof, wherein the polymeric material is composed of biocompatible fibronectin and heparin. The regeneration of peripheral nerves and the construction of tissue engineered nerves are promoted by regulating the expression of MicroRNA genes which can effectively promote the proliferation of primary Schwann cells cultured in vitro and have an anti-apoptotic effect on neuronal cells. In-vivo test proves that bridging of the tissue engineered nerve graft can facilitate the regeneration of peripheral nerves, thus being useful in the treatment of peripheral nerve injury.Type: ApplicationFiled: April 5, 2017Publication date: April 18, 2019Inventors: Xiaosong GU, Fei DING, Xin TANG, Yumin YANG, Bin YU, Shiying LI, Songlin ZHOU, Luzhong ZHANG, Yaxian WANG, Yun GU, Hualin SUN
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Patent number: 9492589Abstract: A tissue engineered nerve graft for repairing peripheral nerve injury consists of a nerve conduit and a extracellular matrix (ECM) that is secreted by autologous or allogeneic support cells and obtained by decellularization. A preparation method of the ECM-modified tissue engineered nerve grafts containing support cells, nerve conduit and constructing a ECM-modified tissue engineered nerve graft.Type: GrantFiled: May 27, 2013Date of Patent: November 15, 2016Assignee: NANTONG UNIVERSITYInventors: Xiaosong Gu, Fei Ding, Yun Gu, Chengbin Xue, Yumin Yang, Yongjun Wang, Leilei Gong
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Publication number: 20150352255Abstract: A tissue engineered nerve graft for repairing peripheral nerve injury consists of a nerve conduit and a extracellular matrix (ECM) that is secreted by autologous or allogeneic support cells and obtained by decellularization. A preparation method of the ECM-modified tissue engineered nerve grafts containing support cells, nerve conduit and constructing a ECM-modified tissue engineered nerve graft.Type: ApplicationFiled: May 27, 2013Publication date: December 10, 2015Inventors: XIAOSONG GU, FEI DING, YUN GU, CHENGBIN XUE, YUMIN YANG, YONGJUN WANG, LEILEI GONG
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Publication number: 20110270411Abstract: The present invention discloses an artificial nerve graft prepared by electrostatic spinning, the preparing method and a special apparatus used therefor. Said artificial nerve graft is in the shape of a tube composed of nano-fiber that is prepared by electrostatic spinning of a polymer. The materials used in the present invention are bio-degradable materials and of desirable biocompatibility with human body. The product of the present invention is free of exogenous toxic substances or substances having side effects. Furthermore, the tube wall is of a 3-dimensional structure having micropores contained therein thereby providing a path for supplying nutritions required for the growth of nerve cells. Another advantage of the present invention is that necessary induction and space are provided for the growth of the nerve cells.Type: ApplicationFiled: March 31, 2010Publication date: November 3, 2011Inventors: Yumin Yang, Xiaosong Gu, Fei Ding, Shanqing Xu, Xiaoli Yan
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Patent number: 8000806Abstract: Methods and equipment used to regenerate sensory, motorial, or visceral signals of injured, broken or diseased nerves of mammalia, such as humans, are provided. In some embodiments, a lineup of downward and upward channels to bridge injured neural channels is disclosed. The downward or upward channels can be connected to electrodes which are in contact with upper or lower nerve stumps. The channels can be used to detect, amplify, and recognize the motorial or sensory signals, to generate related Functional Electrical Stimulation (FES) signals, and to supply the FES signals to the electrodes on the lower or upper nerve stumps. Neural signals can thus be regenerated and the injured motorial or sensory channels can be bridged.Type: GrantFiled: December 25, 2006Date of Patent: August 16, 2011Assignees: Southeast University, Nantong UniversityInventors: Zhigong Wang, Xiaosong Gu, Xiaoying Lv
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Publication number: 20090112286Abstract: Methods and equipment used to regenerate sensory, motorial, or visceral signals of injured, broken or diseased nerves of mammalia, such as humans, are provided. In some embodiments, a lineup of downward and upward channels to bridge injured neural channels is disclosed. The downward or upward channels can be connected to electrodes which are in contact with upper or lower nerve stumps. The channels can be used to detect, amplify, and recognize the motorial or sensory signals, to generate related Functional Electrical Stimulation (FES) signals, and to supply the FES signals to the electrodes on the lower or upper nerve stumps. Neural signals can thus be regenerated and the injured motorial or sensory channels can be bridged.Type: ApplicationFiled: December 25, 2006Publication date: April 30, 2009Applicants: SOUTHEAST UNIVERSITY, NANTONG UNIVERSITYInventors: Zhigong Wang, Xiaosong Gu, Xiaoying Lv
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Publication number: 20080249639Abstract: A medical artificial nerve graft containing silk fibroin used in bridging of nerve damage and its preparation method. The medical artificial nerve graft comprised of vessel or comprised of vessel and fibre scaffold, wherein at least one of the vessel and the fibre scaffold contains component of silk fibroin, and the wall of the vessel has three-dimensional structure provided with numerous microaptures. The preparation method includes the following steps: silk is used to prepare silk fibre; the silk fibroin fibre is used to prepare the vessel or the fibre scaffold containing silk fibroin; and combining the fibre scaffold with the vessel i.e. inlaying the fibre scaffold into the vessel and so on.Type: ApplicationFiled: December 31, 2005Publication date: October 9, 2008Inventors: Xiaosong Gu, Yumin Yang, Fei Ding, Peiyun Zhang, Yan Liu, Mei Liu, Xuemei Chen, Xiaodong Wang