Abstract: Some implementations relate to methods, systems and computer readable media to provide an aerodynamic force model for real-time distributed physics simulation. According to one aspect, a computer-implemented method includes receiving a description of a mechanism that includes physically coupled geometric assemblies within a virtual experience, with each geometric assembly defining a surface mesh. The description includes motion data of the mechanism. The method further includes, for each geometric assembly, identifying exposed surface areas of the surface mesh. The method further includes evaluating an aerodynamic force model based on the exposed surface areas and the motion data of the mechanism, where the aerodynamic force model includes a pressure coefficient that varies based on an angle of attack and based on windward and leeward facing surfaces. The method further includes integrating the aerodynamic force models into a physics simulation to refine the motion data of the mechanism.

Abstract: Disclosed in various examples are methods, systems, and machine-readable media for exposing a Representational State Transfer (RESTful) interface to users whereby management commands on a datacenter may be issued remotely from the users' workstations for secure, remote management of the datacenter. An application task automation command (e.g., a POWERSHELL® command) is executed remotely by creating a proxy command (e.g., based on a POWERSHELL® cmdlet code) to cause the application task automation command to be executed when the proxy command is remotely invoked and deploying the proxy command to a remote computer, such as the user's workstation. The remote computer issues a request including a user identifier and any parameters for the application task automation command when the corresponding proxy command has been invoked by the remote computer.

Abstract: The present disclosure concerns RNA aptamers that specifically inhibit the protein-protein interaction between MED1 and an estrogen receptor. As shown herein, the aptamers are specific for the LXXLL recognition motif between MED 1 and an estrogen receptor. The present disclosure further concerns pRNA nanoparticles of the RNA aptamers coupled with a further HER2 aptamer that show HER2 specific uptake and subsequent inhibition of cellular proliferation and metastasis in vitro and in vivo. Furthermore, the pRNA nanoparticles showed no adverse effects, signifying a safe and effective composition to specifically target and control HER2 expressing cells.

Abstract: Disclosed in various examples are methods, systems, and machine-readable media for exposing a Representational State Transfer (RESTful) interface to users whereby management commands on a datacenter may be issued remotely from the users' workstations for secure, remote management of the datacenter. An application task automation command (e.g., a POWERSHELL® command) is executed remotely by creating a proxy command (e.g., based on a POWERSHELL® cmdlet code) to cause the application task automation command to be executed when the proxy command is remotely invoked and deploying the proxy command to a remote computer, such as the user's workstation. The remote computer issues a request including a user identifier and any parameters for the application task automation command when the corresponding proxy command has been invoked by the remote computer.

Abstract: A coupling thermal management system of a pure electric vehicle based on phase change heat storage. The system includes a refrigerant circuit and a coolant circuit, where heat exchange can be achieved between the refrigerant circuit and the coolant circuit through a plate type heat exchanger. The refrigerant circuit includes an electric compressor, an inside-vehicle heat exchanger, an outside-vehicle heat exchanger, a bidirectional electronic expansion valve, a four-way directional valve, a gas-liquid separator, first three-way valve, a first gate valve, a second gate valve, a plate type heat exchanger and a refrigerant tube. The coolant circuit includes a battery pack, a phase change material, a heat storage heat exchanger, a water pump, a second three-way valve, a third three-way valve, a fourth three-way valve and a coolant tube. The plate type heat exchanger is also included in the coolant circuit.

Abstract: Disclosed in various examples are methods, systems, and machine-readable media for exposing a Representational State Transfer (RESTful) interface to users whereby management commands on a datacenter may be issued remotely from the users' workstations for secure, remote management of the datacenter. An application task automation command (e.g., a POWERSHELL® command) is executed remotely by creating a proxy command (e.g., based on a POWERSHELL® cmdlet code) to cause the application task automation command to be executed when the proxy command is remotely invoked and deploying the proxy command to a remote computer, such as the user's workstation. The remote computer issues a request including a user identifier and any parameters for the application task automation command when the corresponding proxy command has been invoked by the remote computer.

Abstract: RNA nanoparticles functionalized with a HER2-targeting RNA aptamer and at least one MED1 siRNA for targeted delivery of MED1 siRNA to human cancer cells via human epidermal growth factor receptor 2 (HER2) receptors, pharmaceutical compositions of the inventive RNA nanoparticles, and methods for treating breast, HER2-implicated cancers, and in particular therapeutic-resistant cancer such as tamoxifen-resistant breast cancer, by administering pharmaceutical compositions of the inventive RNA nanoparticles.

Abstract: Disclosed in various examples are methods, systems, and machine-readable media for exposing a Representational State Transfer (RESTful) interface to users whereby management commands on a datacenter may be issued remotely from the users' workstations for secure, remote management of the datacenter. An application task automation command (e.g., a POWERSHELL® command) is executed remotely by creating a proxy command (e.g., based on a POWERSHELL® cmdlet code) to cause the application task automation command to be executed when the proxy command is remotely invoked and deploying the proxy command to a remote computer, such as the user's workstation. The remote computer issues a request including a user identifier and any parameters for the application task automation command when the corresponding proxy command has been invoked by the remote computer.

Abstract: Disclosed in various examples are methods, systems, and machine-readable media for exposing a Representational State Transfer (RESTful) interface to users whereby management commands on a datacenter may be issued remotely from the users' workstations for secure, remote management of the datacenter. An application task automation command (e.g., a POWERSHELL® command) is executed remotely by creating a proxy command (e.g., based on a POWERSHELL® cmdlet code) to cause the application task automation command to be executed when the proxy command is remotely invoked and deploying the proxy command to a remote computer, such as the user's workstation. The remote computer issues a request including a user identifier and any parameters for the application task automation command when the corresponding proxy command has been invoked by the remote computer.

Abstract: RNA nanoparticles functionalized with a HER2-targeting RNA aptamer and at least one MED1 siRNA for targeted delivery of MED1 siRNA to human cancer cells via human epidermal growth factor receptor 2 (HER2) receptors, pharmaceutical compositions of the inventive RNA nanoparticles, and methods for treating breast, HER2-implicated cancers, and in particular therapeutic-resistant cancer such as tamoxifen-resistant breast cancer, by administering pharmaceutical compositions of the inventive RNA nanoparticles.

Abstract: Disclosed in various examples are methods, systems, and machine-readable media for exposing a Representational State Transfer (RESTful) interface to users whereby management commands on a datacenter may be issued remotely from the users' workstations for secure, remote management of the datacenter. An application task automation command (e.g., a POWERSHELL® command) is executed remotely by creating a proxy command (e.g., based on a POWERSHELL® cmdlet code) to cause the application task automation command to be executed when the proxy command is remotely invoked and deploying the proxy command to a remote computer, such as the user's workstation. The remote computer issues a request including a user identifier and any parameters for the application task automation command when the corresponding proxy command has been invoked by the remote computer.