Abstract: By introducing at least one cysteine residue based on wild-type IL-2, the binding plane of the IL-2 derivative and ? receptor subunit is partially or completely blocked, while the affinity of the IL-2 derivative to the complex of ? and ? receptor subunits is basically retained. A complex includes an IL-2 derivative, which is introduced with a third cysteine residue based on wild-type IL-2; and a blocking module, which has or is introduced with a fourth cysteine residue. The third cysteine residue on the IL-2 derivative and the fourth cysteine residue on the blocking module are capable of forming an intermolecular disulfide bond, thereby forming a complex of the IL-2 derivative and the blocking module. The binding plane of the IL-2 derivative and ? receptor subunit is partially or completely blocked, while the affinity of the IL-2 derivative to the complex of ? and ? receptor subunits is basically retained.

Abstract: Disclosed is an automatic die cleaning device with reusable cleaning fluid. The automatic die cleaning device includes a robot, a cleaning fluid cyclic-spraying system and a die overturning mechanism. The automatic die cleaning device can spray the cleaning fluid to a die to clean oil stains off the surface of the wheel die, thus realizing the function of automatically cleaning the oil stains off the surface of the die; and the automatic die cleaning device also has the function of reusing the cleaning fluid, thereby saving the cleaning fluid and reducing the influence on the environment. The cleaned die surface is smooth, and the effect is ideal. The automatic die cleaning device reduces the labor intensity, meets the requirement of high-efficiency production, and improves the production efficiency.

Abstract: Provided a die lubricant rotating spray tray device, wherein the nozzles, the connecting sleeve bodies, the nozzle connecting pipes, the air pipe joints and the lubricant pipe joints are sequentially connected to form independently-communicated cavity pipelines, compressed air is input from the air pipe joints, a lubricant is input from the lubricant pipe joints, the rotation driving mechanisms drive the spray tray rotators to rotate through the transmission mechanisms, and the spray tray rotators drive the nozzles to rotate, so that the same dosage of the lubricant is sprayed on the maximum pitch circle surfaces of upper and lower dies, the aim of uniformly spraying the forging lubricant on the working surfaces of the upper and lower dies is achieved.

Abstract: The amino acid sequence of the present IL-15 analog includes the amino acid sequence of IL-15 and an amino acid sequence including at least one positively charged amino acid added to the C-terminal of the amino acid sequence of IL-15. The present IL-15 analog is highly expressed in Escherichia Coli, wherein the expression level is about 20-fold higher than that of the wild-type IL-15, and there is no significant difference in cell activity in vitro. In addition, a conjugate of the IL-15 analog improves the half-life and the long-term efficacy of the IL-15 analog by coupling with the fatty acid chain. These improvements lay a foundation for the industrialization of IL-15 protein drugs.

Abstract: A wheel automatic closed die forging production line includes a sawing machine, a first transfer track, a bar heating furnace, a first manipulator, an oscillating rolling machine, a second manipulator, a primary forging hydraulic machine, an intermediate heating furnace, a third manipulator, a finish forging hydraulic machine, a wheel transfer block, a fourth manipulator, a cutting, expanding and punching hydraulic machine, a second transfer track, a spinning machine, a fifth manipulator, a third transfer track, a heat treatment furnace, a fourth transfer track, a machining unit, a sixth manipulator and a fifth finished product track, and can improve mechanical and the physical properties of the wheel product, the wheel forging effect and the yield. Aluminum and magnesium alloy wheel compression molding is realized, reducing cost, time and labor for secondary machining and reshaping, and improving production safety and efficiency.

Abstract: Provided a spray tray device capable of rotatably spraying a die lubricant, wherein a rotating driving mechanism drive the rotating shafts and the spray tray rotators to rotate, and several external nozzles are arranged on the spray tray rotators. The air pipe joints and the lubricant pipe joints respectively input compressed air and a lubricant into cavities, formed between the spray tray rotators and the connection sleeve bodies, through the nozzle connection pipes, and then the compressed air and the lubricant are sprayed out through the external nozzles. The device implements that the same dosage of the lubricant is uniformly sprayed into the surfaces of the maximum pitch circles of upper and lower dies.

Abstract: Provided is a rotating spray device for a lubricant, wherein the rotating driving mechanism rotates to drive the rotating spindle, and the rotating spindle drives the upper and lower rotating spray trays to rotate, and compressed air and a lubricant are respectively fed into each pitch circle closed cavity formed between each of the rotating spray trays and the spray tray main body, and then are sprayed out through the nozzles on the rotating spray trays for uniform spray coating. The device can spray the same and uniform dosage of the lubricant to the working surfaces of the maximum pitch circles of upper and lower dies, play a role of uniform forging lubrication and reduce the forging defects.

Abstract: A forging and inclined window hole punching composite die includes an upper die holder, a connection sleeve, an upper die sliding sleeve, a pressure plate, inclined window puncher pins, a center puncher pin, first connection screw rods, first springs, second connection screw rods, second springs, hydraulic assistant systems, a lower die and a bottom plate. Bottom surface of the pressure plate of the composite die is a plane to avoid deformation of a front molding surface. Hydraulic power is added to the inclined window puncher pins to increase the pressure for punching inclined holes, avoid quality problems and increase a demolding force. A multi-split synchronous hydraulic device may well realize synchronization of the plurality of inclined window puncher pins.

Abstract: The disclosure belongs to the technical field of die cleaning, and particularly relates to an automatic die cleaning device with reusable cleaning fluid. The automatic die cleaning device with reusable cleaning fluid comprises a robot, a cleaning fluid cyclic-spraying system and a die overturning mechanism. The automatic die cleaning device can spray the cleaning fluid to a die to clean oil stains off the surface of the wheel die, thus realizing the function of automatically cleaning the oil stains off the surface of the die; and the automatic die cleaning device also has the function of reusing the cleaning fluid, thereby saving the cleaning fluid and reducing the influence on the environment. The cleaned die surface is smooth, and the effect is ideal. The automatic die cleaning device reduces the labor intensity, meets the requirement of high-efficiency production, and improves the production efficiency.

Abstract: Provided a spray tray device capable of rotatably spraying a die lubricant, wherein a rotating driving mechanism drive the rotating shafts and the spray tray rotators to rotate, and several external nozzles are arranged on the spray tray rotators. The air pipe joints and the lubricant pipe joints respectively input compressed air and a lubricant into cavities, formed between the spray tray rotators and the connection sleeve bodies, through the nozzle connection pipes, and then the compressed air and the lubricant are sprayed out through the external nozzles. The device implements that the same dosage of the lubricant is uniformly sprayed into the surfaces of the maximum pitch circles of upper and lower dies.

Abstract: Provided a die lubricant rotating spray tray device, wherein the nozzles, the connecting sleeve bodies, the nozzle connecting pipes, the air pipe joints and the lubricant pipe joints are sequentially connected to form independently-communicated cavity pipelines, compressed air is input from the air pipe joints, a lubricant is input from the lubricant pipe joints, the rotation driving mechanisms drive the spray tray rotators to rotate through the transmission mechanisms, and the spray tray rotators drive the nozzles to rotate, so that the same dosage of the lubricant is sprayed on the maximum pitch circle surfaces of upper and lower dies, the aim of uniformly spraying the forging lubricant on the working surfaces of the upper and lower dies is achieved.

Abstract: Provided is a rotating spray device for a lubricant, wherein the rotating driving mechanism rotates to drive the rotating spindle, and the rotating spindle drives the upper and lower rotating spray trays to rotate, and compressed air and a lubricant are respectively fed into each pitch circle closed cavity formed between each of the rotating spray trays and the spray tray main body, and then are sprayed out through the nozzles on the rotating spray trays for uniform spray coating. The device can spray the same and uniform dosage of the lubricant to the working surfaces of the maximum pitch circles of upper and lower dies, play a role of uniform forging lubrication and reduce the forging defects.

Abstract: A forging and inclined window hole punching composite die includes an upper die holder, a connection sleeve, an upper die sliding sleeve, a pressure plate, inclined window puncher pins, a center puncher pin, first connection screw rods, first springs, second connection screw rods, second springs, hydraulic assistant systems, a lower die and a bottom plate. Bottom surface of the pressure plate of the composite die is a plane to avoid deformation of a front molding surface. Hydraulic power is added to the inclined window puncher pins to increase the pressure for punching inclined holes, avoid quality problems and increase a demolding force. A multi-split synchronous hydraulic device may well realize synchronization of the plurality of inclined window puncher pins.

Abstract: A wheel automatic closed die forging production line includes a sawing machine, a first transfer track, a bar heating furnace, a first manipulator, an oscillating rolling machine, a second manipulator, a primary forging hydraulic machine, an intermediate heating furnace, a third manipulator, a finish forging hydraulic machine, a wheel transfer block, a fourth manipulator, a cutting, expanding and punching hydraulic machine, a second transfer track, a spinning machine, a fifth manipulator, a third transfer track, a heat treatment furnace, a fourth transfer track, a machining unit, a sixth manipulator and a fifth finished product track, and can improve mechanical and the physical properties of the wheel product, the wheel forging effect and the yield. Aluminum and magnesium alloy wheel compression molding is realized, reducing cost, time and labor for secondary machining and reshaping, and improving production safety and efficiency.

Abstract: In various embodiments, methods and systems for optimizing data transfer are provided. Data transfer optimization is accomplished by a data transfer optimization server. A data transfer session is initiated. The initiation of the data transfer session comprises analyzing transfer parameters for one or more data-source devices. An optimum number of concurrent network calls is calculated for the data transfer session. The calculation is based on the data transfer parameters. At least a portion of the optimum number of concurrent network calls is allocated for executing the data transfer session. The transfer parameters are monitored for changes. The optimum number of concurrent network calls is updated for the data transfer session based on a triggering event associated with the data transfer session. Updating the optimum number of concurrent network calls comprises recalculating the optimum number of concurrent network calls based on the transfer parameters after the trigger event.

Abstract: In various embodiments, methods and systems for optimizing data transfer are provided. Data transfer optimization is accomplished by a data transfer optimization server. A data transfer session is initiated. The initiation of the data transfer session comprises analyzing transfer parameters for one or more data-source devices. An optimum number of concurrent network calls is calculated for the data transfer session. The calculation is based on the data transfer parameters. At least a portion of the optimum number of concurrent network calls is allocated for executing the data transfer session. The transfer parameters are monitored for changes. The optimum number of concurrent network calls is updated for the data transfer session based on a triggering event associated with the data transfer session. Updating the optimum number of concurrent network calls comprises recalculating the optimum number of concurrent network calls based on the transfer parameters after the trigger event.

Abstract: A digital PLL may be combined with an analog PLL so that the output of the digital PLL is at a frequency high enough to maintain stability in the analog PLL when an initial reference clock signal is too low to maintain stability in the analog PLL. The digital PLL may include a scaling circuit, such as a frequency divider in the feedback path of the PLL, to generate the higher frequency output signal from the lower frequency reference input signal. The digital PLL may also use an on-chip free run ring oscillator as the clock for the digital PLL engine.

Abstract: A digital PLL may be combined with an analog PLL so that the output of the digital PLL is at a frequency high enough to maintain stability in the analog PLL when an initial reference clock signal is too low to maintain stability in the analog PLL. The digital PLL may include a scaling circuit, such as a frequency divider in the feedback path of the PLL, to generate the higher frequency output signal from the lower frequency reference input signal. The digital PLL may also use an on-chip free run ring oscillator as the clock for the digital PLL engine.