Abstract: Disclosed is an application of sBCMA as a biomarker in cerebrospinal fluid in diagnosis and monitoring of antibody-mediated central nervous system autoimmune diseases. Taking NMOSD as an example, the level of sBCMA in cerebrospinal fluid of NMOSD patients is significantly higher than that of control subjects matched for age and gender, and there is a positive correlation between the level of sBCMA in cerebrospinal fluid and a nerve injury-related index NFL, a blood-cerebrospinal fluid barrier breakdown-related index QAlb, or a neuroinflammation-related index sTREM2 in cerebrospinal fluid of NMOSD patients. This indicates that the level of sBCMA in cerebrospinal fluid can be used as a biomarker for the diagnosis of antibody-mediated central nervous system autoimmune diseases such as NMOSD and the evaluation of the severity of nerve injuries, the degree of damage to blood-cerebrospinal fluid barrier, and the level of neuroinflammation in patients.

Abstract: Disclosed is a CAR-T cell with good blood-brain barrier permeability, a product, and use thereof, relating to the technical field of treatment of central nervous system diseases. Based on the study on CAR-T cell immunotherapy for central nervous system diseases, this disclosure provides a CAR-T cell with good blood-brain barrier permeability and a corresponding drug for treating or improving the central nervous system diseases. The CAR-T cell targets B-cell maturation antigens and highly expresses a chemokine receptor CXCR3 and chemokines CCL1, CCL3, and CCL4. This disclosure further provides a product for detecting and judging the blood-brain barrier permeability of the CAR-T cell, such as probes, reagents, and kits, which can accurately detect and judge the blood-brain barrier permeability of a specific CAR-T cell.

Abstract: The present invention provides a design method of a high energy efficiency Unmanned Aerial Vehicle (UAV) communication system assisted by an intelligent reflecting surface, and belongs to the technical field of UAV communication network energy efficiency optimization. A communication process comprises two transmission links, one link is directly sent from an information source to an information sink, and the other link is reflected and transmitted by an intelligent reflecting surface attached to a UAV. The two links exist simultaneously. Based on an idea of block iteration, an original problem is decomposed into three sub-problems, and a non-convex optimization problem is transformed into solvable concave-convex fractional program problems by a continuous convex approximation technique. The present invention provides a design method for joint optimization of a passive beamforming of the intelligent reflecting surface, an active beamforming of a base station and a flight trajectory of the UAV.

Abstract: A design method of a high energy efficiency unmanned aerial vehicle (UAV) green data acquisition system belongs to the technical field of data acquisition and optimization for UAV uplink communication. Firstly, a system optimization objective is constructed; and in a uplink communication network of a single UAV and ground sensors, the UAV receives data periodically. Secondly, according to a constructed optimization problem, the optimization objective is maximization of EE({W},{t},{S}). Finally, an original problem is decomposed into two approximate concave-convex fractional sub-problem based on a block coordinate descent method and a successive convex approximation technique to obtain a suboptimal solution; an overall iterative algorithm is proposed: in each iteration, by solving the sub-problems, wake-up scheduling S, time slot t and UAV trajectory W are alternately optimized. The solution obtained in each iteration is used as the input of next iteration.

Abstract: The present invention provides a design method of a high energy efficiency Unmanned Aerial Vehicle (UAV) communication system assisted by an intelligent reflecting surface, and belongs to the technical field of UAV communication network energy efficiency optimization. A communication process comprises two transmission links, one link is directly sent from an information source to an information sink, and the other link is reflected and transmitted by an intelligent reflecting surface attached to a UAV. The two links exist simultaneously. Based on an idea of block iteration, an original problem is decomposed into three sub-problems, and a non-convex optimization problem is transformed into solvable concave-convex fractional program problems by a continuous convex approximation technique.

Abstract: A design method of a high energy efficiency unmanned aerial vehicle (UAV) green data acquisition system belongs to the technical field of data acquisition and optimization for UAV uplink communication. Firstly, a system optimization objective is constructed; and in a uplink communication network of a single UAV and ground sensors, the UAV receives data periodically. Secondly, according to a constructed optimization problem, the optimization objective is maximization of EE({W},{t},{S}). Finally, an original problem is decomposed into two approximate concave-convex fractional sub-problem based on a block coordinate descent method and a successive convex approximation technique to obtain a suboptimal solution; an overall iterative algorithm is proposed: in each iteration, by solving the sub-problems, wake-up scheduling S, time slot t and UAV trajectory W are alternately optimized. The solution obtained in each iteration is used as the input of next iteration.