Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: A light-emitting device and a display panel. A light-emitting color of the light-emitting device is a primary color of either red or green, and the light-emitting device includes: a light-emitting layer with a host material; a compensation layer for carrying holes and disposed on a hole injection side of the light-emitting layer; the light-emitting device has a starting state and an operating state, and a starting voltage of the light-emitting device in the starting state is lower than an operating voltage of the light-emitting device in the operating state; in the starting state, there is a first activation energy difference value ?Ea1 between activation energies of the host material and the compensation layer, and the first activation energy difference value ?Ea1<0 eV.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: A method for electric field measurement based on a levitated particle includes steps of (1) capturing a particle and levitating the captured particle; (2) adjusting a quantity of electric charge carried by the levitated particle; (3) measuring a charge number N of the levitated particle; (4) disposing the levitated particle in an electric field to be measured, measuring a displacement power spectral density Svxel of the levitated particle under the electric field and obtaining an electric field force Fel; and (5) according to a formula of E=Fel/Nqe, obtaining an electric field intensity E. An apparatus for electric field measurement based on a levitated particle includes a high-voltage DC (direct current) power supply, two bare wire electrodes, a vacuum chamber, a trapping laser, an objective lens, a pair of parallel electrodes, a collective lens, a quadrant photodetector, a lock-in amplifier, a signal generator and a power amplifier.

Abstract: An absolute gravimeter and a measurement method based on vacuum optical tweezers. The micro-nano particle releasing device is equipped with micro-nano particles, and is located above laser optical tweezers, and the laser optical tweezers have two capturing beams which pass through the respective convergent lenses and then converge at an intersection. An area where the intersection is located serves as an optical trap capturing region, and the micro-nano particles are stably captured by the two capturing beams in the optical trap capturing region. The optical interferometer is electrically connected to the signal processing device, the optical interferometer measures a displacement of the micro-nano particles in real time at the beginning of a free fall process from the optical trap capturing region and sends the displacement signal to the signal processing device. The signal processing device obtains a measured value of an absolute gravitational acceleration.

Abstract: A method for electric field measurement based on a levitated particle includes steps of (1) capturing a particle and levitating the captured particle; (2) adjusting a quantity of electric charge carried by the levitated particle; (3) measuring a charge number N of the levitated particle; (4) disposing the levitated particle in an electric field to be measured, measuring a displacement power spectral density Svxel of the levitated particle under the electric field and obtaining an electric field force Fel; and (5) according to a formula of E=Fel/Nqe, obtaining an electric field intensity E. An apparatus for electric field measurement based on a levitated particle includes a high-voltage DC (direct current) power supply, two bare wire electrodes, a vacuum chamber, a trapping laser, an objective lens, a pair of parallel electrodes, a collective lens, a quadrant photodetector, a lock-in amplifier, a signal generator and a power amplifier.

Abstract: A method for enhancing vacuum tolerance of optical levitation particles includes steps of: (1) turning on a trapping laser to form an optical trap, loading the particles to an effective capture region of the optical trap, and collecting scattered light signals; (2) turning on the preheating laser, and directing a preheating laser beam to the captured particles; (3) adjusting a power of the preheating laser until a particle heating rate is larger than a heat dissipation rate; (4) turning on the vacuum pump, and stopping evacuating when a vacuum degree is greater than a vacuum inflection point of a first reduction of the effective capture region of the optical trap; and (5) turning off the preheating laser when the scattered light signals collected by the photodetector no longer changes. The present invention improves a stable capture probability of the particles in high vacuum environment.

Abstract: A method for enhancing vacuum tolerance of optical levitation particles includes steps of: (1) turning on a trapping laser to form an optical trap, loading the particles to an effective capture region of the optical trap, and collecting scattered light signals; (2) turning on the preheating laser, and directing a preheating laser beam to the captured particles; (3) adjusting a power of the preheating laser until a particle heating rate is larger than a heat dissipation rate; (4) turning on the vacuum pump, and stopping evacuating when a vacuum degree is greater than a vacuum inflection point of a first reduction of the effective capture region of the optical trap; and (5) turning off the preheating laser when the scattered light signals collected by the photodetector no longer changes. The present invention improves a stable capture probability of the particles in high vacuum environment.

Abstract: Disclosed is a multi-dimensional optical tweezers calibration device based on electric field quantity calibration and a method thereof. The polarization-dependent characteristics of a tightly focused optical trap are utilized to realize triaxial electric field force calibration of particles through a one-dimensional electric field quantity calibration device. The method of the present application enables a particle electric field force calibration system to be compatible with particle delivery and particle detection systems; the device is simplified and calibration complexity is reduced.