Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses macrocyclic compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The disclosure provides a method for breeding Carassius auratus strains without intermuscular bones, which comprises designing knockout target sites for the two copies of the bmp6, bmp6a and bmp6b, in the Carassius auratus genome, and then obtaining F2 generation individuals from a homozygous line with bmp6a and bmp6b double gene mutation through two rounds of gene knockout and screening, and then propagating by using the F2 generation individuals from the homozygous line with bmp6a and bmp6b double gene mutation to form a new Carassius auratus strain with intermuscular bone-deficient. Strains of Carassius auratus with less than 20 intermuscular bones and without intermuscular bones are obtained by the method of the present disclosure.

Abstract: An air supply system, comprising at least two air blowers and at least two communication valves; wherein one air blower is connected to a main air passage through the corresponding communication valve; and at least one other is connected to a reformer air passage and a stack air passage through at least one other communication valve, respectively. At least two air blowers are provided to connect the at least two communication valves.

Abstract: Disclosed are steerable cannulas and hinged or steerable needles including access sets and methods thereof. A steerable cannula can include a compound tube, a cannula tip, a compound hub, and an articulation mechanism. A distal-end portion of the compound tube can include a flexible hinge for adjusting a cannula angle between proximal and distal portions of the compound tube adjacent the flexible hinge. A cannula tip coupled to a distal end of the compound tube can include a tip opening fluidly connected to a lumen of the compound tube. The compound hub is disposed about a proximal-end portion of the compound tube. The articulation mechanism is controlled by at least a rotatable element of the compound hub for adjusting the cannula angle. The articulation mechanism is configured to longitudinally move an inner tube of the compound tube relative to an outer tube to adjust the cannula angle.

Abstract: A surgical stapling device includes a staple reload and a handle assembly that supports a drive rack, a motor assembly, a gear assembly, a reload select mechanism, and a safety toggle mechanism. The gear assembly is adapted to facilitate uncoupling of the motor assembly from the drive rack to allow manual movement of the drive rack. The reload select mechanism allows the length of a stroke of the drive rack to be selectively adjusted to allow the stapling device to accommodate different length staple reloads. The safety toggle mechanism is provided to move the stapling device from a non-firing state to a firing state to allow for firing of the stapling device.

Abstract: A surgical stapling device includes a staple reload and a handle assembly that supports a drive rack, a motor assembly, a gear assembly, a reload select mechanism, and a safety toggle mechanism. The gear assembly is adapted to facilitate uncoupling of the motor assembly from the drive rack to allow manual movement of the drive rack. The reload select mechanism allows the length of a stroke of the drive rack to be selectively adjusted to allow the stapling device to accommodate different length staple reloads. The safety toggle mechanism is provided to move the stapling device from a non-firing state to a firing state to allow for firing of the stapling device.

Abstract: An air supply system, comprising at least two air blowers and at least two communication valves; wherein one air blower is connected to a main air passage through the corresponding communication valve; and at least one other is connected to a reformer air passage and a stack air passage through at least one other communication valve, respectively. At least two air blowers are provided to connect the at least two communication valves.

Abstract: The present application discloses a car power supply system and a solid oxide fuel cell vehicle. The car power supply system specifically comprises a first battery, a vehicle control unit (VCU), a lithium battery management system, a solid oxide fuel cell control unit, a second battery, a first relay and a second relay. If a solid oxide fuel cell controlled by the solid oxide fuel cell control unit provided by the present application cannot stop working within a short time, the first relay restores the first battery to power the VCU and the lithium battery management system after a start switch stops power supply by the first battery, so that the solid oxide fuel cell control unit is powered by the second battery to make the cell work normally and realize power off, thereby preventing the problem that the solid oxide fuel cell cannot work due to rapid power failure of the vehicle.

Abstract: Disclosed is an articulated stiffening cannula (100, 200, 300, 400). The articulated stiffening cannula (100, 200, 300, 400) include a cannula tube (110, 210, 310, 410), a compound hub (130, 230, 330, 430) disposed about a proximal-end portion of the cannula tube (110, 210, 310, 410) and an articulation mechanism controlled by a rotatable element (132, 232, 332) of the compound hub (130, 230, 330, 430). The cannula tube (110, 210, 310, 410) can include a flexible hinge (114, 214, 314, 414) along a distal length of the cannula tube (110, 210, 310, 410), and can be configured to articulate at the flexible hinge (114, 214, 314, 414) for adjusting a cannula-tube angle between a distal-end portion of the cannula tube (110, 210, 310, 410) and a proximal length of the cannula tube (110, 210, 310, 410).

Abstract: A sheath stabilizer can include a housing, a clamp in the housing, and an adhesive pad disposed on a base of the housing. The housing can include a sheath passageway longitudinally extending through the housing and the base oblique to the sheath passageway. The clamp can be located in a proximal-end portion of the housing around the sheath passageway. The adhesive pad can be disposed on the base and can be configured for adhering the sheath stabilizer to at least a patients skin. The sheath stabilizer can be part of a sheath-and-stabilizer assembly, which can include a sheath configured for percutaneous access. Methods for the sheath stabilizer are described.

Abstract: A needle-tract assistants (100, 200) for establishing a needle tract of a predetermined length, including a needle thruster (110, 210) and a needle-in-catheter assembly (130, 230) removably loaded in the needle thruster (110, 210). The needle thruster (110, 210) can include a cradle (112, 212), a carriage(114, 214) within the cradle (112, 212), and a plunger (116, 216) coupled to the carriages (114, 214). The carriages (114, 214) can be configured to move between a proximal-end portion and a distal-end portion of the cradle(112, 212). The plungers (116, 216) can be configured to move the carriages (114, 214) within the cradle(112, 212). The plungers (116, 216) can also be configured to allow a user to set the predetermined length of the needle tract before establishing the needle tract.

Abstract: A surgical stapling device includes a staple reload and a handle assembly that supports a drive rack, a motor assembly, a gear assembly, a reload select mechanism, and a safety toggle mechanism. The gear assembly is adapted to facilitate uncoupling of the motor assembly from the drive rack to allow manual movement of the drive rack. The reload select mechanism allows the length of a stroke of the drive rack to be selectively adjusted to allow the stapling device to accommodate different length staple reloads. The safety toggle mechanism is provided to move the stapling device from a non-firing state to a firing state to allow for firing of the stapling device.

Abstract: A network-slice selection method, device and system are provided. The method includes: obtaining one or more of a network-slice selection policy, user subscription information, a network-slice selection assistance parameter, and a user context by a network-slice selection control function entity; and determining network-slice selection information according to one or more of the network-slice selection policy, the user subscription information, the network-slice selection assistance parameter, and the user context by the network-slice selection control function entity, and transmitting the determined network-slice selection information to a network-slice routing function entity, so that the network-slice routing function entity performs routing for signaling or data.

Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.

Abstract: The invention provides isoquinoline, quinoline, and quinazoline derivatives to treat a variety of disorders, diseases and pathologic conditions, and more specifically to the use of isoquinoline, quinoline, and quinazoline derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds to the treatment of hyperproliferative diseases and pathologic angiogenesis.

Abstract: An apparatus comprising: at least one processor; and at least one memory including computer program code, the at least one memory and the computer program code configured to, with the at least one processor, cause the apparatus to perform at least the following: provide for first and second operational modes for a set of a plurality of user interface elements, the plurality of user interface elements in the set being associated with respective applications, wherein in the first operational mode, the set of the plurality of user interface elements is displayed such that limited contextual content is provided, the limited contextual content being associated with the respective applications and in the second operational mode, the set of the plurality of user interface elements is displayed such that additional contextual content Is provided, the additional contextual content being associated with the respective applications.

Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.

Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.