Abstract: A test system and a test method for a lip sticking force of tipping paper for cigarettes are provided. The test system includes an artificial lip and test equipment. The artificial lip is a silica gel block. The test equipment includes a friction meter testing platform, a force measuring sensor, a rigid rope, a pulley, a pulley bracket and a sample loading module. The pulley is installed on the pulley bracket, and the rigid rope slides in the pulley. The rigid rope is L-shaped, a first end of the rigid rope in a horizontal direction is connected to the force measuring sensor, and a second end of the rigid rope in a vertical direction is connected to the sample loading module. The artificial lip is located directly below the sample loading module, and the artificial lip is in contact with the sample loading module at a test position.

Abstract: The present disclosure belongs to the field of chemical industry production, and particularly relates to CD-MOFs and a preparation method thereof. The preparation method comprises the following steps: (1) formulating a supersaturated ?-cyclodextrin alkaline alcohol aqueous solution containing an alkali metal ion; (2) heating to obtain a hot ?-cyclodextrin solution; and (3) cooling the hot ?-cyclodextrin solution of the step (2), and performing crystallization and separation to obtain the cyclodextrin-based metal organic framework material. The CD-MOFs has perfect crystallization and large specific surface area, which are similar with those of a material prepared by means of traditional methods. The important thing is that the synthesis operation thereof is simple, green, and environmentally friendly, and the time required is shortened from a few hours or even tens of hours to a few minutes, which significantly improves the synthesis efficiency and is conductive to industrial scale production.

Abstract: Disclosed are a M-cell targeting and pH-responsive starch-based carrier material, and a preparation method and application thereof. The starch-based carrier material has a molecular structure as follows, a molecular weight of 7.04×104 to 2.11×106 g/mol, a degree of substitution of carboxymethyl groups of 0.04 to 0.28, and a grafting amount of targeting peptide GRGDS of 0.01% to 1.12% (calculated based on the content of N). The material is not dissolved in water when protonated at pH (pH=1.2) of the stomach, and is slowly dissolved in water when deprotonated at pH (pH=6.8) of the small intestine, therefore it has good responsiveness to pH of the gastrointestinal tract. The material can efficiently encapsulate a positively charged active substance by means of electrostatic interaction, therefore it can protect the active substances from being destroyed and inactivated in the gastrointestinal tract.

Abstract: Provided are a viral vector for treating autoimmune disease and diabetes and a construction method and an application thereof. The viral vector is a lentiviral expression plasmid or an adeno-associated viral expression plasmid cloned with mfat-1 gene, and the mfat-1 gene is as shown in SEQ ID NO: 1.

Abstract: The present invention discloses uses of a novel phosphodiesterase 4 (PDE4) inhibitor ZL-n-91 in preparing drugs against lung cancer proliferation and metastasis. The mouse survival curves and in vitro cell experiments show that the PDE4 inhibitor ZL-n-91 can significantly inhibit the proliferation and metastasis of lung cancer cells, indicating that this PDE4 inhibitor ZL-n-91 can become an important target for the studies on anti-lung cancer proliferation and metastasis, to provide a basis for preparing drugs against lung cancer proliferation and metastasis, with promising prospect of development and application.

Abstract: Disclosed is a 3D printing technology-based method for use in adjusting the digestibility of highland barley starch, comprising the following steps: (1) after mixing highland barley starch with water, adding an edible oil, thoroughly and uniformly mixing, and then forming a starch-oil complex system, the mass ratio of highland barley starch to water and oil being 1:(0.5-2):(0.2-1); (2) adding the uniformly mixed starch-oil complex system into a material cylinder of a 3D printer, setting a transfer temperature to 50° C.-100° C. and maintaining for 10-30 min, then performing 3D printing at a printing temperature of 150° C.-210° C. to obtain a highland barley starchy food product having a 3D stereoscopic shape.

Abstract: The present invention discloses a novel phosphodiesterase 4 (PDE4) inhibitor ZL-n-91 for applications in preparing drugs for treating proliferation and metastasis of prostate cancer. The animal experiments and cytological experiments in mice showed that the PDE4 inhibitor ZL-n-91 of the present invention can significantly inhibit the proliferation and metastasis of prostate cancer cells, indicating that the PDE4 inhibitor ZL-n-91 is expected to be an important target for treating proliferation and metastasis of prostate cancer. It will lay a foundation for preparing drugs against proliferation and metastasis of prostate cancer, presenting good prospect for development and application.

Abstract: A control element comprising a support; a control part which defines at least one operating surface, which is movable or elastically yielding if an operating force F acts upon the operating surface; a layer structure that is disposed between the control part and the support and that is elastically deformed if an operating force F acts on the operating surface. The layer structure has at least one first electrode associated with the support and a second electrode, which is associated with the control part and disposed underneath the operating surface, for the definition of a measuring capacity varying in accordance with the operating force. The layer structure further has an intermediate layer having a recess which is disposed between the first and second electrodes for defining a hollow chamber; and means for venting the hollow chamber. The means for venting is integrated at least partially into the intermediate layer.

Abstract: The present invention discloses uses of a novel phosphodiesterase 4 (PDE4) inhibitor ZL-n-91 in preparing drugs against lung cancer proliferation and metastasis. The mouse survival curves and in vitro cell experiments show that the PDE4 inhibitor ZL-n-91 can significantly inhibit the proliferation and metastasis of lung cancer cells, indicating that this PDE4 inhibitor ZL-n-91 can become an important target for the studies on anti-lung cancer proliferation and metastasis, to provide a basis for preparing drugs against lung cancer proliferation and metastasis, with promising prospect of development and application.

Abstract: A starch-based food thickener with low molecular weight and a preparation method thereof, comprising the steps of: adding starch powders with 5%-30% moisture content into an atmospheric pressure low-temperature dielectric barrier discharge plasma reactor, regulating the discharge gap to 0.2 mm-0.8 mm at atmospheric pressure, the discharge input voltage to 30 V-70 V, and the discharge current to 0.2 A-2.4 A, subjecting the materials in a fluidized state to plasma action in the circulating system by regulating the air flow rate with controlling time longer than 0.5 min, and then taking out the product after the completion of the reaction, i.e., to obtain a starch-based food thickener with low molecular weight. The method has such advantages as a simple technique involved, low cost, recyclable processing, large processing capacity, superior reaction uniformity, etc., and is also capable of efficiently and quickly degrading the molecular weight of starch, e.g., by 1-3 order(s) of magnitude within a short time.

Abstract: The current invention discloses a genetically engineered bacterium used for the treatment of breast cancer. The said bacterium is attenuated Salmonella typhimurium VNP20009 with cloned L-methioninase gene. The method for constructing this genetically engineered bacterium and the application thereof are also disclosed herein. In the current invention, our biologic drug for the treatment of breast cancer is a type of safe, non-toxic new drug with anti-tumor activity. It can highly express methioninase through recombinant DNA technology using attenuated Salmonella typhimurium VNP20009 as a carrier, which has a strong anti-tumor activity and can meet the needs. The preparation method is simple and easy to operate, showing good application prospect.

Abstract: A control element comprising a support; a control part which defines at least one operating surface, which is movable or elastically yielding if an operating force F acts upon the operating surface; a layer structure that is disposed between the control part and the support and that is elastically deformed if an operating force F acts on the operating surface. The layer structure has at least one first electrode associated with the support and a second electrode, which is associated with the control part and disposed underneath the operating surface, for the definition of a measuring capacity varying in accordance with the operating force. The layer structure further has an intermediate layer having a recess which is disposed between the first and second electrodes for defining a hollow chamber; and means for venting the hollow chamber. The means for venting is integrated at least partially into the intermediate layer.

Abstract: The current invention discloses a genetically engineered bacterium used for the treatment of breast cancer. The said bacterium is attenuated Salmonella typhimurium VNP20009 with cloned L-methioninase gene. The method for constructing this genetically engineered bacterium and the application thereof are also disclosed herein. In the current invention, our biologic drug for the treatment of breast cancer is a type of safe, non-toxic new drug with anti-tumor activity. It can highly express methioninase through recombinant DNA technology using attenuated Salmonella typhimurium VNP20009 as a carrier, which has a strong anti-tumor activity and can meet the needs. The preparation method is simple and easy to operate, showing good application prospect.

Abstract: The present invention provides methods for the preparation of protein hydrolysate, peptide solution and peptide from BSG. The wet BSG or BSG powder is dispersed in extract solution to prepare the crude BSG protein or the crude BSG protein solution. Preparing the crude BSG protein solution using the crude BSG protein and adjusting the pH to 6.5˜8.5, or adjusting the pH of the crude BSG protein solution to 6.5˜8.5. Then the solution is hydrolyzed with protease at 45° C. to 65° C. for 1 h to 5 h in a water bath shaker to prepare BSG protein hydrolysate. The protein hydrolysate is heated to inactivate the protease and centrifuged to obtain the peptide solution. The peptide solution is separated by gel filtration and each peak is collected and pooled together to obtain the peptide. The protein hydrolysate, peptide solution and peptide in the present invention are all prepared from BSG which is a natural product and available at low cost throughout the year.