Abstract: The present application discloses an apparatus and a device for sensing an analyte contained in liquid. The apparatus provided by the present application includes a liquid flow structure component and a sensing component. The liquid flow structure component includes: a measurement chamber configured to receive the analyte to be sensed, and wherein a sensible electrical signal is generated when the analyte to be sensed enters the measurement chamber along a first direction; an outlet chamber in fluid connection with the measurement chamber; and a nanochannel including a first opening connecting with the measurement chamber and a second opening connecting with the outlet chamber, wherein a height difference between the first opening and the second opening of the nanochannel in the first direction is less than 20 ?m. The sensing component is coupled to the measurement chamber to sense the electrical signal.

Abstract: Disclosed are a molecule detection unit, a chip and a preparation method. The molecule detection unit includes a single-hole liquid storage cavity, a liquid resistance flow channel, a buffer flow channel, a sensing electrode, a substrate, a first structural layer, a second structural layer and a sample flow channel. The first structural layer is arranged on the top of the substrate; the single-hole liquid storage cavity and the buffer flow channel are arranged in the first structural layer and are independent of each other; the liquid resistance flow channel is arranged in the first structural layer, and two ends of the liquid resistance flow channel are respectively communicated with the single-hole liquid storage cavity and the buffer flow channel; the second structural layer is arranged on the top of the first structural layer and covers the top of the buffer flow channel.

Abstract: The present application discloses an apparatus and a device for sensing an analyte contained in liquid. The apparatus provided by the present application includes a liquid flow structure component and a sensing component. The liquid flow structure component includes: a measurement chamber configured to receive the analyte to be sensed, and wherein a sensible electrical signal is generated when the analyte to be sensed enters the measurement chamber along a first direction; an outlet chamber in fluid connection with the measurement chamber; and a nanochannel including a first opening connecting with the measurement chamber and a second opening connecting with the outlet chamber, wherein a height difference between the first opening and the second opening of the nanochannel in the first direction is less than 20 ?m. The sensing component is coupled to the measurement chamber to sense the electrical signal.