Abstract: The present disclosure provides a dimer formed by two polypeptide chains, with each of the two polypeptide chains comprising an antibody Fc subunit, wherein the dimer comprises two or more immunoglobulin single variable domains (ISVDs), at least one of the ISVDs is specific for PD-L1, and at least one of the ISVDs is specific for CTLA4.

Abstract: A pixel circuit, a driving method thereof, a display panel and a display apparatus are provided. The pixel circuit includes a light-emitting element, a first voltage terminal, a data signal line, a light emission control sub-circuit, and a photoelectric sensing sub-circuit. The light emission control sub-circuit is connected with the first voltage terminal, the data signal line and the light-emitting element. The photoelectric sensing sub-circuit is connected with the first voltage terminal and the data signal line.

Abstract: A display panel and an electronic device. The display panel includes a holing area and a display area surrounding the holing area, and the display panel is provided with row lines extending in a first direction, and column lines extending in a second direction; some row lines are separated by the holing area into mutually corresponding first row line sections and second row line sections; some column lines are separated by the holing area into mutually corresponding first column line sections and second column line sections; at least some of the first column line sections are electrically connected to the corresponding second column line sections by means of corresponding transfer lines located in the display area; and/or at least some of the first row line sections are electrically connected to the corresponding second row line sections by means of corresponding transfer lines located in the display area.

Abstract: The invention discloses a durable roof structure with frost resistance and high ductility and a construction method thereof, belonging to the technical field of roofing, and comprises a base layer, a leveling layer, a flexible waterproof coating, a thermal insulation layer and a crack-resistant and frost-resistant surface layer arranged in sequence from bottom to top. The invention not only has lower requirements on construction conditions and simple operation, but also reduces the generation of large cracks, effectively improves the crack resistance and frost resistance of the roof, improves the roof structure, and is more suitable for the northern cold region.

Abstract: This disclosure provides a feed network, an antenna apparatus, and a communication device. A main portion is disposed with a first electric-conductor and a second electric-conductor. In addition, two branch portions are disposed, one end of a first branch portion is electrically connected to the first electric-conductor, and one end of a second branch portion is electrically connected to the second electric-conductor. In this way, when two radiation parts in a same polarization direction of a radiating element are electrically connected to the first branch portion and the second branch portion respectively, a transmission structure of the feed network may feed two radio frequency signals, for example, two equi-amplitude phase-inverted radio frequency signals, into the two radiation parts of the radiating element respectively. The feed network in this embodiment of this application has a simple line, so that space occupied by the feed network in the antenna apparatus is reduced.

Abstract: A pixel circuit, a driving method, and a display device are provided. The pixel circuit includes a light emitting element, a driving circuit, a first energy storage circuit, a first setting circuit, a second setting circuit and a light emitting control circuit. The first setting circuit controls to connect the first setting voltage terminal and the first node under the control of the first control signal provided by the first control terminal; the second setting circuit controls to connect the second setting voltage terminal and the second terminal of the first energy storage circuit under the control of the second control signal provided by the second control terminal.

Abstract: The present invention relates to the pharmaceutical and biological field, and discloses a single-domain antibody against coagulation factor XI (FXI) and derived protein thereof. In particular, the present invention discloses a coagulation factor XI (FXI) binding protein derived from a single-domain antibody against coagulation factor XI (FXI) and use thereof.

Abstract: The present disclosure provides use of sweetpotato IbSAP15 gene in regulating leaf shape and flower shape of sweetpotato. Compared with the control, Ipomoea batatas cv. Xuzishu 8, IbSAP15-overexpressing lines have more deeply incised blades, dehiscent corollas, and higher ornamental value. In the present disclosure, overexpression of the sweetpotato IbSAP15 gene in sweetpotato can deepen leaf incisions, make trumpet-shaped corollas dehiscent, and change leaf shape and flower shape of sweetpotato. The present disclosure is suitable for developing sweetpotato germplasms with different leaf shape and flower shape and promotes ornamental flowering/foliage sweetpotato breeding.

Abstract: The present disclosure provides use of sweetpotato IbSAP15 gene in regulating leaf shape and flower shape of sweetpotato. Compared with the control, Ipomoea batatas cv. Xuzishu 8, IbSAP15-overexpressing lines have more deeply incised blades, dehiscent corollas, and higher ornamental value. In the present disclosure, overexpression of the sweetpotato IbSAP15 gene in sweetpotato can deepen leaf incisions, make trumpet-shaped corollas dehiscent, and change leaf shape and flower shape of sweetpotato. The present disclosure is suitable for developing sweetpotato germplasms with different leaf shape and flower shape and promotes ornamental flowering/foliage sweetpotato breeding.

Abstract: A human GLP-1 polypeptide variant, and a fusion protein or an immunoconjugate constructed by means of using the human GLP-1 polypeptide variant can be used for preventing, and/or treating metabolic diseases or conditions related to GLP-1.

Abstract: The present invention relates to the field of medical biology, and discloses a single domain antibody and derivative proteins thereof against CTLA4. In particular, the present invention discloses a CTLA4 binding protein and the use thereof, especially the use for treating and/or preventing CTLA4 relevant diseases such as tumor.

Abstract: Provided are proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.

Abstract: A pluripotent stem cell, a method for producing the pluripotent stem cell, and the use of the pluripotent stem cell for stem cell differentiation, cell transplantation, tissue repair, and/or tissue regeneration.

Abstract: A device for testing temperature conduction and frost-heaving strain of a concrete lining canal comprises: a frost-heaving device comprising a lining canal body and a temperature control device, the temperature control device being configured to provide a predetermined temperature for the lining canal body; a detection device comprising a transverse deformation detection device, a vertical deformation detection device and a plurality of temperature sensors, the transverse deformation detection device being configured to detect a transverse frost-heaving strain parameter of the lining canal body, and the plurality of temperature sensors being arranged along an axial direction of the lining canal body, being embedded inside the lining canal body and being configured to detect temperature conduction performance of the lining canal body.

Abstract: A visual analysis method for cable element identification includes steps of constructing and labeling a picture data set, preparing a training data set and training a model, to train the preset identification and analysis model, such that the preset identification and analysis model can have accuracy of identification of cable elements; then, cable element information existing in a target image screen is identified by the completely trained preset identification and analysis model, so as to label a target picture; in the analysis method, the produced and manufactured cable elements can be shot, and then, shot pictures are identified and analyzed by using the preset identification and analysis model, such that a structural quality condition of each cable element is rapidly and comprehensively determined, possible structural defects of each cable element can be conveniently and accurately known, and the cable elements with unqualified quality can be screened out in time.

Abstract: The invention discloses an experimental apparatus and an experimental method for the negative bending moment zone of a continuous beam to bear load under chloride environment, relating to the technical field of engineering experiment, comprising a high-rigidity main frame, a loading system, an erosion system and a test beam; the test beam is detachably arranged on the high-rigidity main frame; the loading system is installed on the high-rigidity main frame and under the test beam, and is used to apply load to the test beam; the erosion system is arranged on the test beam with built-in chloride solution; the test beam is a continuous beam that meets the design requirements. The experimental apparatus provided by the invention is stable and reliable, easy to use, and can provide the experimental conditions for the wet-dry cycle and the load-bearing coupling reaction in chloride environment.

Abstract: The invention discloses a durable roof structure with frost resistance and high ductility and a construction method thereof, belonging to the technical field of roofing, and comprises a base layer, a leveling layer, a flexible waterproof coating, a thermal insulation layer and a crack-resistant and frost-resistant surface layer arranged in sequence from bottom to top. The invention not only has lower requirements on construction conditions and simple operation, but also reduces the generation of large cracks, effectively improves the crack resistance and frost resistance of the roof, improves the roof structure, and is more suitable for the northern cold region.

Abstract: The present disclosure provides a dimer formed by two polypeptide chains, with each of the two polypeptide chains comprising an antibody Fc subunit, wherein the dimer comprises two or more immunoglobulin single variable domains (ISVDs), at least one of the ISVDs is specific for PD-L1, and at least one of the ISVDs is specific for CTLA4.

Abstract: A pixel circuit, a driving method thereof, a display panel and a display apparatus are provided. The pixel circuit includes a light-emitting element, a first voltage terminal, a data signal line, a light emission control sub-circuit, and a photoelectric sensing sub-circuit. The light emission control sub-circuit is connected with the first voltage terminal, the data signal line and the light-emitting element. The photoelectric sensing sub-circuit is connected with the first voltage terminal and the data signal line.

Abstract: The invention relates to the field of biomedicine, and an anti-pertussis toxin (PT) single domain antibody and derivative protein thereof are disclosed. Specifically, a pertussis toxin-binding protein and use thereof are disclosed.