Abstract: An ion channel blocker for treatment and/or prevention of hepatic fibrosis is provided. Based on the fact that the activation of hepatic stellate cells is an important link in anti-hepatic fibrosis, it is found that gliclazide has the effect of inhibiting the activation of hepatic stellate cells by in vitro and in vivo experiments. Further exploration reveals that gliclazide mainly inhibits the activation of hepatic stellate cells by inhibiting autophagy pathways, and thus the gliclazide can be used to prepare medicaments for treatment and/or prevention of hepatic fibrosis.

Abstract: An application of a channel blocker in preparation of drugs for treating and/or preventing liver fibrosis is provided, belonging to the field of biomedical technology. A new use of phenytoin sodium is provided. It is demonstrated that at the cell level, the phenytoin sodium can improve liver fibrosis by regulating autophagy and thus affecting the activation of hepatic stellate cells. In this situation, the efficacy of the phenytoin sodium on liver fibrosis is verified at the animal level by establishing a disease model, and the phenytoin sodium can be used to prepare drugs for treating and/or preventing liver fibrosis.

Abstract: An application of potassium ion (K+) channel blocker in preparation of drugs for treating liver fibrosis is provided, which relates to the field of medical technologies. The K+ channel blocker is sotalol, the sotalol is originally used as an antiarrhythmic drug in clinic and has a property of inhibiting K+ channels. Experiments show that sotalol can effectively inhibit liver fibrosis and reduce expression of fibrosis-related protein alpha-smooth muscle actin (?-SMA), specifically by regulating expression and/or function of autophagy and epithelial-mesenchymal transition (EMT) molecules to achieve inhibition of hepatic stellate cell (HSC) fibrosis, so as to provide a new drug choice for clinical treatment of the liver fibrosis.

Abstract: The present disclosure provides an imaging method using a mobile magnetic resonance apparatus, which includes: randomly sampling an object-to-be-scanned using a mobile magnetic resonance apparatus to acquire encoding of the frequency and phase of the tissue of the object-to-be-scanned, and obtain target K-space data; inputting the target K-space data and pre-generated denoising reconstruction network parameters into a pre-trained denoising reconstruction network; where the pre-trained denoising reconstruction network is generated by training based on fully sampled training data; and outputting a magnetic resonance image corresponding to the object-to-be-scanned.

Abstract: A method for monitoring and analyzing large tunnel machines based on automatic collection of big data includes the following steps: dividing a tunnel operation area, obtaining environmental information of a tunnel operation sub-area, analyzing rock drilling difficulty of the tunnel operation sub-area, confirming a tunnel operation trajectory, analyzing conformity of the tunnel operation sub-area, processing an abnormal tunnel operation sub-area, and analyzing health state of a tunnel rock drill. According to the present disclosure, a rock drilling difficulty coefficient of each tunnel operation sub-area is used to analyze a corresponding steel rotating speed, and then the tunnel operation trajectory is confirmed. After the tunnel operation is completed, the operation conformity of each tunnel operation sub-area is analyzed, and each abnormal tunnel operation sub-area is screened out and processed accordingly.

Abstract: The present invention relates to a lithium-ion battery and an electric vehicle utilizing the lithium-ion battery. The lithium-ion battery comprises a housing, and battery cell group disposed in the housing, wherein, a fire-extinguishing material layer is provided between the battery cell group and the housing, and the housing is provided with drain hole. The technical scheme of the present invention can effectively prevent fire and explosion of lithium-ion battery, and can significantly improve the safety of lithium-ion battery in use.

Abstract: The present invention relates to a lithium-ion battery and an electric vehicle utilizing the lithium-ion battery. The lithium-ion battery comprises a housing, and battery cell group disposed in the housing, wherein, a fire-extinguishing material layer is provided between the battery cell group and the housing, and the housing is provided with drain hole. The technical scheme of the present invention can effectively prevent fire and explosion of lithium-ion battery, and can significantly improve the safety of lithium-ion battery in use.