Abstract: A method for producing entacapone tablets, including auxiliary materials passing screening, batching, mixing, sieving, mixing, drying granulation, sieving, mixing with magnesium stearate and pressing finished products. Mannitol, a supplementary material, was prepared by following steps: the mixture of fructose and glucose was hydrolyzed from sucrose; The glucose obtained was further hydrolyzed to obtain a mixture of mannose, fructose and glucose; The mannitol product is obtained by mixing the mannose, fructose and glucose obtained in steps 1 and 2, hydrogenation, refining, concentration, crystallization and pressure filtration; The finished mannitol product is dried and crushed by mixing with water mixed with binder. The compressed mannitol particles with a particle size of 200-350 um are obtained, which are used as auxiliary materials for the preparation of entacapone tablets.