Abstract: The present disclosure provides for multi-specific antibodies and antigen-binding fragments thereof that bind to human CLDN6 and CD3, a pharmaceutical composition comprising said antibody or antigen-binding fragments thereof, and use of the multi-specific antibody or antigen-binding fragments thereof or the composition for treating a disease, such as cancer.

Abstract: The present disclosure provides for antibodies and antigen-binding fragments thereof that bind to human CLDN6, a pharmaceutical composition comprising said antibody or antigen-binding fragments thereof, and use of the antibody or antigen-binding fragments thereof or the composition for treating a disease, such as cancer.

Abstract: Provided are a method, device, system for accessing a network address, WLAN and UE. The method comprises: a trusted WLAN access network acquires a flow routing policy of a UE; and the trusted WLAN access network allocates at least one network address for the UE according to the flow routing policy of the UE. The disclosure solves the problem of a UE being not forward compatible during an authentication process, so as to improve UE compatibility.

Abstract: Provided for an embodiment is a support member for a cryogenic cooler's expander. The support member provides stiffness to the expander to reduce movements at the expander's distal end and may increase the natural frequency of the expander. The support member may increase the natural frequency of the expander at least about two times in the bending and/or twisting sense. The bending natural frequency of the expander and support sub-assembly may be at least about two times greater or lower than the natural frequency of the electrical wires that connect an infrared sensor to a control processing unit to reduce the maximum stress applied to the electrical wires during use. In another embodiment, additional or redundant electrical pathways are provided for connections between the infrared sensor and the CPU. Furthermore, shock absorber and/or shock diverters are provided on rigid pins that connect the electrical wires to the CPU.

Abstract: The present invention relates to a cryogenic cooler's expander supported by a support member, preferably a truncated conical tube. The support member provides additional stiffness to the expander to reduce movements at the distal end of the expander. The support member also increases the natural frequency of the expander. In one embodiment, the support member increases the natural frequency of the expander at least about two (2) times in the bending and/or twisting sense. In another embodiment, the bending natural frequency of the expander and support sub-assembly is at least about two times greater or lower than the natural frequency of the electrical wires that connect the infrared sensor to a control processing unit to reduce the maximum stress applied to the electrical wires during use. In another embodiment, additional or redundant electrical pathways are provided for the connection between the infrared sensor and the CPU.

Abstract: The invention is directed to an improved cryogenic cooler with an expander where the regenerator matrix is decoupled from the displacer or piston, thereby allowing the design of each to be optimized substantially independently. The regenerator matrix is preferably positioned spaced apart from the displacer and can be designed to enhance thermal exchanges and flow rates of the working gas. In one embodiment, the regenerator matrix has a serpentine shape or U-shape disposed around the displacer and the cold finger. Preferably, the regenerator matrix is static. The thermal lengths of the cold finger and/or the displacer can be extended by minimizing their geometrical lengths. Additionally, the structural integrity or stiffness of the cold finger and/or displacer can be strengthened.

Abstract: A compact cryocooler includes a gas compression piston (304) supported for reciprocal linear translation along a first longitudinal axis (308) and a gas displacing piston (362) supported for reciprocal linear translation along a second longitudinal axis (366). The first longitudinal axis (308) and second longitudinal axis (366) are substantially orthogonal. A rotary motor (302) rotates a rotor (324) and associated motor shaft (320) about a motor rotation axis (328) disposed substantially parallel with the second longitudinal axis (366). Motor shaft (320) first and second mounting features (336, 340) traverse first and second eccentric paths around the motor rotation axis. A first drive coupling couples the first mounting feature (336) with the gas compression piston (304) and delivers a reciprocal linear translation along the first longitudinal axis (308) thereto.

Abstract: An integrated sensor assembly (10) includes a gas compression unit (104) having a first longitudinal axis (308) and a gas expansion unit (112) having a second longitudinal axis (366) and the gas expansion unit is disposed with its second longitudinal axis orthogonal to the gas compression unit first longitudinal axis (308). A rotary motor (302) includes a rotor (324) supported for rotation with respect to a motor rotation axis (328) and the sensor assembly configuration is folded to orient the motor rotation axis substantially parallel with the second longitudinal axis (366). A motor shaft (320) extending from the rotor includes a first and second mounting features (336, 340) disposed substantially parallel with and radially offset from the motor rotation axis (328). A first drive coupling couples between the first mounting feature (336) and a gas compression piston (304) and drives the piston (304) with a reciprocal linear translation directed along the first longitudinal axis (308).

Abstract: A compact cryocooler includes a gas compression piston (304) supported for reciprocal linear translation along a first longitudinal axis (308) and a gas displacing piston (362) supported for reciprocal linear translation along a second longitudinal axis (366). The first longitudinal axis (308) and second longitudinal axis (366) are substantially orthogonal. A rotary motor (302) rotates a rotor (324) and associated motor shaft (320) about a motor rotation axis (328) disposed substantially parallel with the second longitudinal axis (366). Motor shaft (320) first and second mounting features (336, 340) traverse first and second eccentric paths around the motor rotation axis. A first drive coupling couples the first mounting feature (336) with the gas compression piston (304) and delivers a reciprocal linear translation along the first longitudinal axis (308) thereto.

Abstract: An integrated sensor assembly (10) includes a gas compression unit (104) having a first longitudinal axis (308) and a gas expansion unit (112) having a second longitudinal axis (366) and the gas expansion unit is disposed with its second longitudinal axis orthogonal to the gas compression unit first longitudinal axis (308). A rotary motor (302) includes a rotor (324) supported for rotation with respect to a motor rotation axis (328) and the sensor assembly configuration is folded to orient the motor rotation axis substantially parallel with the second longitudinal axis (366). A motor shaft (320) extending from the rotor includes a first and second mounting features (336, 340) disposed substantially parallel with and radially offset from the motor rotation axis (328). A first drive coupling couples between the first mounting feature (336) and a gas compression piston (304) and drives the piston (304) with a reciprocal linear translation directed along the first longitudinal axis (308).

Abstract: A control (30) for controlling a variable valve actuation mechanism (26) of an internal combustion engine (10) to regenerate a particulate filter (35) in the exhaust system (25) of the engine. The control comprises an operating program (50, 50A) for regenerating the particulate filter while the engine is running under its owns power by causing the variable valve actuation mechanism to change the timing of engine cylinder valves during an engine operating cycle, and as a result, elevate the temperature of flow through the exhaust system to a temperature that is effective to combust particles trapped by the filter.

Abstract: A control (30) for controlling a variable valve actuation mechanism (26) of an internal combustion engine (10) to regenerate a NOx adsorber catalyst (35) in the exhaust system (22) of the engine. The control comprises an operating program (50) for regenerating the catalyst while the engine is running under its own power by causing the variable valve actuation mechanism to change the timing of operation of the intake valves (18) so as to transition the fuel-air ratio of mixture that is being combusted in the cylinders (16) from a relatively leaner mixture to a mixture that sufficiently richer than stoichiometric to effectively regenerate the catalyst.

Abstract: A control (30) for controlling a variable valve actuation mechanism (26) of an internal combustion engine (10) to regenerate a NOx adsorber catalyst (35) in the exhaust system (22) of the engine. The control comprises an operating program (50) for regenerating the catalyst while the engine is running under its own power by causing the variable valve actuation mechanism to change the timing of operation of the intake valves (18) so as to transition the fuel-air ratio of mixture that is being combusted in the cylinders (16) from a relatively leaner mixture to a mixture that sufficiently richer than stoichiometric to effectively regenerate the catalyst.

Abstract: A control (30) for controlling a variable valve actuation mechanism (26) of an internal combustion engine (10) to regenerate a particulate filter (35) in the exhaust system (25) of the engine. The control comprises an operating program (50, 50A) for regenerating the particulate filter while the engine is running under its owns power by causing the variable valve actuation mechanism to change the timing of engine cylinder valves during an engine operating cycle, and as a result, elevate the temperature of flow through the exhaust system to a temperature that is effective to combust particles trapped by the filter.

Abstract: A control (30) embodies an operating strategy (50) to facilitate engine cranking and starting via control of timing of cylinder intake (18) and exhaust (24) valve opening using a variable valve actuation mechanism (26). Prior to fueling any cylinder (16), the engine (10) is cranked while the variable valve actuation mechanism causes pistons (32) to operate at an initial effective compression ratio for initial cranking that is less than an effective compression ratio for running when the engine is eventually fueled and runs under its own power. Thereafter, and still before fueling, they are caused to operate at an increased effective compression ratio, and still thereafter, a portion of their charges are drawn from the exhaust system (22). As the engine warms up, valve timing is adjusted.

Abstract: A control (30) embodies an operating strategy (50) to facilitate engine cranking and starting via control of timing of cylinder intake (18) and exhaust (24) valve opening using a variable valve actuation mechanism (26). Prior to fueling any cylinder (16), the engine (10) is cranked while the variable valve actuation mechanism causes pistons (32) to operate at an initial effective compression ratio for initial cranking that is less than an effective compression ratio for running when the engine is eventually fueled and runs under its own power. Thereafter, and still before fueling, they are caused to operate at an increased effective compression ratio, and still thereafter, a portion of their charges are drawn from the exhaust system (22). As the engine warms up, valve timing is adjusted.