Abstract: Provided are certain novel pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused heterocyclic derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.

Abstract: Provided are certain novel pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused heterocyclic derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.

Abstract: A Schottky diode comprises: a semiconductor layer and a three-terminal port located on a side of the semiconductor layer; the three-terminal port comprises a first electrode, a second electrode, and a third electrode located between the first electrode and the second electrode, at least a part of the second electrode extends into the semiconductor layer and forms a Schottky contact with the semiconductor layer, the second electrode and the third electrode are electrically connected to form an anode of the Schottky diode, and the first electrode is in ohmic contact with the semiconductor layer as a cathode of the Schottky diode; when the Schottky diode is subjected to a reverse bias voltage, a depletion layer is formed under the third electrode.