Abstract: This invention relates to substituted fused heterocyclic C-glycosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X.

Abstract: Substituted indazole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.

Abstract: This invention relates to substituted fused heterocyclic C-glycosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X.

Abstract: Substituted indazole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.

Abstract: A client generates a session key and a delegation ticket containing information for a requested delegation operation. The client generates a first copy of the session key and encrypts it using a public key of a proxy. The client generates a second copy of the session key and encrypts it using a public key of a server. The client then puts the encrypted session keys and delegation ticket into a first message that is sent to the proxy. The proxy extracts and decrypts its copy of the session key from the first message. The proxy then encrypts a proof-of-delegation data item with the session key and places it and the delegation ticket along with the encrypted copy of the session key for the server into a second message, which is sent to the server. The server extracts and decrypts its copy of the session key from the second message and uses the session key to obtain the proof-of-delegation data. Authority is successfully delegated to the proxy only if the server can verify the proof-of-delegation data.

Abstract: A method, an apparatus, a system, and a computer program product are presented for validating certificates. A certificate validation service receives a certificate validation request for a target certificate from a client, thereby allowing the client to offload certificate validation tasks into an online certificate validation service that is accessible and sharable by multiple components within a data processing system. In response to a determination that the target certificate is valid or invalid, the certificate validation service sends a certificate validation response with an indicating status value that the target certificate is valid or invalid. The certificate validation service is able to cache information about previously validated certificates and the associated certificate chains, thereby enhancing the efficiency of the service. Different certificate validation policies may be applied against target certificates based upon information associated with the target certificates.

Abstract: An analysis of at least one authentication token for an application is provided. At least one login module within the application is identified. Responsive to a failure to access the application, principal information is retrieved associated with the at least one login module. A recovery action is then generated. The recovery action corresponds to the failure and the principal information.

Abstract: A method, apparatus, and computer implemented instructions for synchronizing time in a network data processing system. A request for time synchronization is received at a target data processing system. A current target time at the target data processing system is placed in a reply. The reply is sent to the source data processing system. A current source time from when the reply is received at the source data processing system is compared to the current target time to generate a comparison. A synchronization factor is generated using the comparison.

Abstract: A method, apparatus, and computer implemented instructions for synchronizing time in a network data processing system. A request for time synchronization is received at a target data processing system. A current target time at the target data processing system is placed in a reply. The reply is sent to the source data processing system. A current source time from when the reply is received at the source data processing system is compared to the current target time to generate a comparison. A synchronization factor is generated using the comparison.

Abstract: This invention relates to low molecular weight, non-peptidic, non-peptidomimetic, organic molecules that act as modulators of mammalian complement C5a receptors, preferably ones that act as high affinity C5a receptor ligands and also to such ligands that act as antagonists or inverse agonists of complement C5a receptors. Preferred compounds of the invention possess some or all of the following properties in that they are: 1) multi-aryl in structure, 2) heteroaryl in structure, 3) a pharmaceutically acceptable oral dose can provide a detectable in vitro effect, 4) comprise fewer than four or preferably no amide bonds, and 5) capable of inhibiting leukocyte chemotaxis at nanomolar or sub-nanomolar concentrations. This invention also relates to pharmaceutical compositions comprising such compounds and the use of such compounds in treating a variety of inflammatory and immune system disorders. Additionally, this invention relates to the use such compounds as probes for the localization of C5a receptors.

Abstract: A method, program and system for mapping ASN.1 data to an object model are provided. The invention consists of identifying the start of a data stream and then generating a new object name for the data. Next, the data is parsed to get the identifier and the data length. Then the data's tag type is analyzed. If the tag type is simple, a class diagram is generated for the data and then the source code for the data is generated. If the tag type is not simple, a subroutine is called to further parse the data before generating the class diagram and source code.

Abstract: A method and apparatus for establishing a secure communication connection between a Java application or applet and a secure server is provided. An HTTPS handler is provided that may be used by Java applications or applets to establish secure communication connections with secure Web servers.

Abstract: Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.

Abstract: This invention relates to substituted fused heterocyclic C-glycosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X.

Abstract: Substituted indazole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.

Abstract: This invention relates to low molecular weight, non-peptidic, non-peptidomimetic, organic molecules that act as modulators of mammalian complement C5a receptors, preferably ones that act as high affinity C5a receptor ligands and also to such ligands that act as antagonists or inverse agonists of complement C5a receptors, preferably human C5a receptors, Preferred compounds of the invention possess one or more, and preferably two or more, three or more, four or more, or all of the following properties in that they are; 1) multi-aryl in structure (having a plurality of un-fused or fused aryl groups), 2) heteroaryl in structure, 3) orally available in vivo (such that a sub-lethal or preferably a pharmaceutically acceptable oral dose can provide a detectable in vitro effect such as a reduction of C5a-induced neutropenia), 4) comprised of fewer than four, preferably fewer than three, or fewer than two, or no amide bonds, and 5) capable of inhibiting leukocyte chemotaxis at nanomolar concentrations and preferably at

Abstract: Disclosed are compounds of the formula: or pharmaceutically acceptable addition salts thereof wherein: R1, R2, R3 R4 and R5, R6, R7, and R8 represent organic and/or inorganic substituents as defined herein, which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.

Abstract: An analysis of at least one authentication token for an application is provided. At least one login module within the application is identified. Responsive to a failure to access the application, principal information is retrieved associated with the at least one login module. A recovery action is then generated. The recovery action corresponds to the failure and the principal information.

Abstract: Disclosed are 1-Azatricyclic-4-benzylpiperazine compounds which are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents. Pharmaceutical compositions, including packaged pharmaceutical compositions, are further provided. Compounds of the invention are also useful as probes for the localization of GABAA receptors in tissue samples.

Abstract: Provided are compounds (and pharmaceutically acceptable non-toxic salt of such compounds) of the formula: in which A and B are C1-C3 alkylene; R1 is C1-C6 alkyl; R2 and R3 are hydrogen or C1-C6 alkyl; U and V are C1-C6 alkyl or halogen; X, Y and Z are hydrogen, C1-C6 alkyl, trifluoromethyl, C1-C6 alkoxy, trifluoromethoxy, halogen, or cyano; and W represents up to three substituents which are C1-C6 alkyl, trifluoromethyl, C1-C6 alkoxy, trifluoromethoxy, halogen, hydroxy, amino, or cyano. These compounds act as modulators of blood glucose levels and are useful for the treatment of diabetes, eating disorders, and obesity. Pharmaceutical compositions and methods of use of the compounds as pharmaceutical agents are also provided.