Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Abstract: The present invention discloses a xylose hydrolysate decolorization and filtration device. A hydrolysate is filtered through a to-be-cleaned filtering machine to form a waste carbon liquid with a light transmittance of 7% to 10%, the waste carbon liquid is subjected to pressure filtration through a filter press to form a plate and frame liquid, the plate and frame liquid is filtered through a to-be-passed-through filtering machine to form a pre-decolorized liquid with a light transmittance of 30% to 35%, the pre-decolorized liquid enters a decolorization tank and is mixed with added new carbon in the decolorization tank to form a new carbon liquid, and the new carbon liquid is filtered through a standby filtering machine to form a decolorized liquid with a light transmittance of greater than 65%. The present invention further discloses a xylose hydrolysate decolorization and filtration method using the device.

Abstract: Related to is a system for preparing xylose liquid by continuously hydrolyzing hemicellulose, including a neutralizing unit, an acid-adjusting unit, a feeding unit, a liquefaction ejecting unit, a feed and discharge heat-exchanging unit and a discharge controlling unit. The neutralizing unit includes a raw material tank, a neutralizing concentrated sulfuric acid pump and a neutralizing pipeline mixer, the acid-adjusting unit includes an acid-adjusting concentrated sulfuric acid pump, an acid-adjusting pipeline mixer and an acid-adjusting tank, the feeding unit includes a feed tank, the liquefaction ejecting unit includes a liquefaction ejector and a liquefaction maintainer, the feed and discharge heat-exchanging unit includes a plate-type teed and discharge heat exchanger and a first discharge temperature sensor, and the discharge controlling unit includes a discharge valve and a reflux valve.

Abstract: The present invention discloses a data processing method and system for a scalable multi-port memory. The multi-port memory is a 2-read n-write multi-port memory unit. The method comprises: assembling two 2R1W memories into one Bank memory unit; assembling n/2 Bank memory units in depth into a hardware architecture of one 2-read n-write multi-port memory unit; under one clock cycle, when data is written into the 2-read n-write multi-port memory unit, if the size of the data is less than or equal to the bit width of the 2R1W memory, writing the data into different 2R1W memories respectively; and if the size of the data is greater than the bit width of the 2R1W memory, waiting for a second clock cycle, and when the second clock cycle comes, writing the high and low bits of the written data into the two 2R1W memories of one Bank memory unit respectively.

Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Abstract: The present invention discloses a data buffer processing method and system for a 4R4W fully-shared packet. The method comprises: assembling two 2R1 memories into one Bank memory unit; forming the hardware architecture of a 4R4W memory based on four Bank memory units; under one clock cycle, when data is written into the 4R4W memory, if the size of the data is less than or equal to the bit width of the 2R1W memory, writing the data into different Banks respectively, and copying the written data and writing, the copied data into the two 2R1W memories of each Bank respectively; if the size of the data is greater than the memory, waiting for a second clock, cycle, and writing the data into different Banks respectively, and writing the high and low bits of each piece of written data into the two 2R1W memories of each Bank memory unit respectively.

Abstract: The present invention discloses a data processing method and system for a scalable multi-port memory. The multi-port memory is a 2-read n-write multi-port memory unit. The method comprises: assembling two 2R1W memories into one Bank memory unit; assembling n/2 Bank memory units in depth into a hardware architecture of one 2-read n-write multi-port memory unit; under one clock cycle, when data is written into the 2-read n-write multi-port memory unit, if the size of the data is less than or equal to the bit width of the 2R1W memory, writing the data into different 2R1W memories respectively; and if the size of the data is greater than the bit width of the 2R1W memory, waiting for a second clock cycle, and when the second clock cycle comes, writing the high and low bits of the written data into the two 2R1W memories of one Bank memory unit respectively.

Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Abstract: Embodiments of the present invention relate to portions of a switch fabric having a single logical stage and at least one physical stage. In addition, the data paths and the control paths of the switch fabric can be decoupled thereby allowing additional processing to be performed than would otherwise be the case with control rates that matched the high data rates. In other words, data cells received on high speed links can be spread over many lower speed links; consequently, the data cells can transit the switch fabric at that high speed while the control information associated with the data can be processed at that lower speed. Because the control information can be processed at a lower speed (associated with the control path), the control information can be processed over a greater period of time.

Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Abstract: Embodiments of the present invention relate to portions of a switch fabric having a single logical stage and at least one physical stage. In addition, the data paths and the control paths of the switch fabric can be decoupled thereby allowing additional processing to be performed than would otherwise be the case with control rates that matched the high data rates. In other words, data cells received on high speed links can be spread over many lower speed links; consequently, the data cells can transit the switch fabric at that high speed while the control information associated with the data can be processed at that lower speed. Because the control information can be processed at a lower speed (associated with the control path), the control information can be processed over a greater period of time.

Abstract: Embodiments of the present invention relate to portions of a switch fabric having a single logical stage and at least one physical stage. In addition, the data paths and the control paths of the switch fabric can be decoupled thereby allowing additional processing to be performed than would otherwise be the case with control rates that matched the high data rates. In other words, data cells received on high speed links can be spread over many lower speed links; consequently, the data cells can transit the switch fabric at that high speed while the control information associated with the data can be processed at that lower speed. Because the control information can be processed at a lower speed (associated with the control path), the control information can be processed over a greater period of time.

Abstract: Described herein are methods and techniques to study the “degradome”. The degradome of a specific protease is the complete product of the natural substrate repertoire of that enzyme in a cell, tissue or organism. The complete set of proteases that are expressed at a particular moment or circumstance by a cell, tissue or organism produces the collective degradome. Included in the methods described herein are approaches that allow the direct identification and characterization of degradome peptides from approx. 400 to approx. 12,000 Da. The methods of the invention avoid the inherent problems of studying the peptidome by focusing on specific or unique proteolytic cleavages that occur as a result of endogenous protease activity induced by specific diseases. Once characterized, the presence of, or change in level of, specific peptides of the degradome can be used, e.g.

Abstract: Embodiments of the present invention relate to portions of a switch fabric having a single logical stage and at least one physical stage. In addition, the data paths and the control paths of the switch fabric can be decoupled thereby allowing additional processing to be performed than would otherwise be the case with control rates that matched the high data rates. In other words, data cells received on high speed links can be spread over many lower speed links; consequently, the data cells can transit the switch fabric at that high speed while the control information associated with the data can be processed at that lower speed. Because the control information can be processed at a lower speed (associated with the control path), the control information can be processed over a greater period of time.