Abstract: The present disclosure discloses a missing medical diagnosis data imputation method and apparatus, an electronic device and a medium. The method includes the following steps: acquiring a medical diagnosis data set with data missing; randomly dividing original data into initial sample point data and candidate sample point data, and constructing and training a generative adversarial network initial imputation model by utilizing the initial sample point data; estimating an influence of sample points on a parameter of the generative adversarial network initial imputation model and a prediction result of the generative adversarial network initial imputation model by utilizing an influence function; and sampling a sample point with highest influence among the candidate sample point data by utilizing a binary search algorithm, and further iteratively optimizing the generative adversarial network initial imputation model so as to impute missing data for the medical diagnosis data.