Abstract: The present disclosure provides a method, devices, a numerical control machine, and a computer storage medium for detecting machine processing trajectory space. The method includes: obtaining data of a trajectory AB of a machine processing and spatial data of a specified space area; converting a function of the data of the trajectory AB into a univariate function P=f (u) with respect to a trajectory parameter u; determining a point set Ui of the trajectory AB on an inner side of each curved surface Si based on spatial data of the individual curved surfaces Si forming the specified space area and the function P=f(u); and determining a positional relationship between the trajectory AB and the specified space area based on the point sets Ui.

Abstract: A system and method for determining a path for autonomous navigation based on user input is described. The vehicle can include one or more sensors to collect data for generating a three-dimensional (3D) model of the vehicle's surroundings. A two-dimensional (2D) occupancy grid map can be generated from the 3D model and displayed at a computing device. In some examples, the occupancy grid map can be displayed at a user interface of the electronic device. The user interface can further accept user input in the form of one or more of a user-defined path, an endpoint, a vehicle pose, or a series of waypoints. Based on the user input, a finalized path for autonomous vehicle travel can be determined. Determining a finalized path can include determining an optimal, minimum-distance path, applying a smoothing algorithm, and/or applying a constraint to maintain a minimum distance from any static obstacles near the vehicle.

Abstract: A method for cutter path planning is disclosed. The method includes: obtaining a first and a second programmed path of a workpiece, computing for a corresponding first cutter path based on the first programmed path and a radius of the cutter, and computing for a corresponding second cutter path based on the second programmed path and the radius of the cutter; and computing for a transition path connecting an end point of the first cutter path and a start point of the second cutter path based on the first and second cutter paths, wherein the distance from any one point on the transition path to either the first or second programmed path would be greater than or equal to the radius of the cutter. An apparatus for cutter path planning, a method and an apparatus for workpiece machining are also disclosed.

Abstract: Accurate and fast mapping of sequencing reads obtained from a targeted sequencing procedure can be provided. Once a target region is selected, alternate regions of the genome that are sufficiently similar to the target region can be identified. If a sequencing read is more similar to the target region than to an alternate region, then the read can be determined as aligning to the target region. The reads aligning to the target region can then be analyzed to determine whether a mutation exists in the target region. Accordingly, a sequencing read can be compared to the target region and the corresponding alternate regions, and not to the entire genome, thereby providing computational efficiency.

Abstract: Provided herein are methods and compositions to detect mutations in estrogen receptor (ESR1).

Abstract: The present disclosure provides a method, devices, a numerical control machine, and a computer storage medium for detecting machine processing trajectory space. The method includes: obtaining data of a trajectory AB of a machine processing and spatial data of a specified space area; converting a function of the data of the trajectory AB into a univariate function P=f (u) with respect to a trajectory parameter u; determining a point set Ui of the trajectory AB on an inner side of each curved surface Si based on spatial data of the individual curved surfaces Si forming the specified space area and the function P=f (u); and determining a positional relationship between the trajectory AB and the specified space area based on the point sets Ui.

Abstract: A method for cutter path planning is disclosed. The method includes: obtaining a first and a second programmed path of a workpiece, computing for a corresponding first cutter path based on the first programmed path and a radius of the cutter, and computing for a corresponding second cutter path based on the second programmed path and the radius of the cutter; and computing for a transition path connecting an end point of the first cutter path and a start point of the second cutter path based on the first and second cutter paths, wherein the distance from any one point on the transition path to either the first or second programmed path would be greater than or equal to the radius of the cutter. An apparatus for cutter path planning, a method and an apparatus for workpiece machining are also disclosed.

Abstract: The invention comprises suppressor oligonucleotides for reducing amplification of a non-target nucleic acid sequences; the method of designing and using such oligonucleotides, as well as kits and reaction mixtures.

Abstract: Accurate and fast mapping of sequencing reads obtained from a targeted sequencing procedure can be provided. Once a target region is selected, alternate regions of the genome that are sufficiently similar to the target region can be identified. If a sequencing read is more similar to the target region than to an alternate region, then the read can be determined as aligning to the target region. The reads aligning to the target region can then be analyzed to determine whether a mutation exists in the target region. Accordingly, a sequencing read can be compared to the target region and the corresponding alternate regions, and not to the entire genome, thereby providing computational efficiency.

Abstract: The invention comprises suppressor oligonucleotides for reducing amplification of a non-target nucleic acid sequences; the method of designing and using such oligonucleotides, as well as kits and reaction mixtures.

Abstract: Accurate and fast mapping of sequencing reads obtained from a targeted sequencing procedure can be provided. Once a target region is selected, alternate regions of the genome that are sufficiently similar to the target region can be identified. If a sequencing read is more similar to the target region than to an alternate region, then the read can be determined as aligning to the target region. The reads aligning to the target region can then be analyzed to determine whether a mutation exists in the target region. Accordingly, a sequencing read can be compared to the target region and the corresponding alternate regions, and not to the entire genome, thereby providing computational efficiency.

Abstract: Accurate and fast mapping of sequencing reads obtained from a targeted sequencing procedure can be provided. Once a target region is selected, alternate regions of the genome that are sufficiently similar to the target region can be identified. If a sequencing read is more similar to the target region than to an alternate region, then the read can be determined as aligning to the target region. The reads aligning to the target region can then be analyzed to determine whether a mutation exists in the target region. Accordingly, a sequencing read can be compared to the target region and the corresponding alternate regions, and not to the entire genome, thereby providing computational efficiency.

Abstract: The present invention relates to fusion proteins. The invention specifically relates to compositions and methods of Tf-based fusion proteins that demonstrate a high-level expression of transferrin (Tf)-based fusion proteins by inserting a helical linker between two protein domains.

Abstract: The present invention relates to fusion proteins. The invention specifically relates to compositions and methods of Tf-based fusion proteins that demonstrate a high-level expression of transferrin (Tf)-based fusion proteins by inserting a helical linker between two protein domains.

Abstract: The present invention relates to fusion proteins. The invention specifically relates to compositions and methods of Tf-based fusion proteins that demonstrate a high-level expression of transferrin (Tf)-based fusion proteins by inserting a helical linker between two protein domains.

Abstract: The present invention relates to fusion proteins. The invention specifically relates to compositions and methods of Tf-based fusion proteins that demonstrate a high-level expression of transferrin (Tf)-based fusion proteins by inserting a helical linker between two protein domains.

Abstract: The present invention relates, inter alia, to compounds that bind tubulin and exhibit anti-mitotic properties and to methods of using such compounds to inhibit abnormal cell mitosis and, in particular, to inhibit tumor cell growth. In addition, methods are presented of treating mammalian diseases associated with undesired and uncontrolled angiogenesis.

Abstract: A process is provided for oxidatively modifying nucleic acids containing a target nucleotide. The nucleic acid is contacted with a polyaza metal complex in the presence of an oxidizing agent so that the nucleic acid is modified at or near the target nucleotide. Also provided are a kit for carrying out the process and a method for treating neoplastic growth by administering to a subject having neoplastic growth, an effective amount of a polyaza metal complex which is capable of modifying DNA.