Abstract: This description relates to a molecular marker for early pancreatic neoplasm detection, a detection method and use thereof. The pancreatic cancer marker miRNAs: miR-30c, miR-24, miR-23a and miR-132. The combination, method and kit provided by the present invention can be used for screening and differential diagnosis of early pancreatic cancer, monitoring of disease complications and recurrence, evaluation of curative effect, drug efficacy and guidance of precise drug use, etc., and it has the advantages of a wide detection spectrum, high sensitivity, good specificity, low detection cost, convenient material acquisition, and easy storage of samples. This method can be widely used in the early screening and prognosis of pancreatic cancer, improving the low specificity and low sensitivity caused by the individual differences that are difficult to overcome due to the instability of a single marker or biomarkers currently widely used in clinical practice.

Abstract: The invention provides methods for the treatment of cancer. The invention also provides a method for identifying a subject whose cancer is likely to respond to combination ICOS agonist and PD1 antagonist therapy, the method comprising determining the RNA signature (Table 1) score of a sample of the cancer of the subject.

Abstract: Methods and devices for signal amplification and/or analyzing a chemical analyte using an electrochemical cell containing colloidal suspension of conductive or redox active nanoparticles in a liquid sample are provided. The liquid sample includes a plurality of electrogenerated chemiluminescent (ECL) moieties and one or more chemical analytes. The colloidal suspension of nanoparticles in the liquid sample are in contact with one or more electrodes of the electrochemical cell. The methods and devices may also employ an optical detection system, which is capable of measuring one or more transient optical properties resulting from redox reactions of the ECL moieties catalyzed by interaction of the nanoparticles with one of the electrodes.

Abstract: Methods and devices for analyzing a chemical analyte using an electrochemical cell connected to a measuring apparatus are provided. The electrochemical cell contains a solution having one or more conductive or redox active NPs, one or more chemical analytes, and an indicator. In addition, the electrochemical cell contains one or more electrodes in communication with the solution. One or more catalytic ECL properties are generated by the interaction of the one or more conductive or redox active NPs and the liquid sample and measured at the one or more electrodes or with an optical detection system.

Abstract: Methods, compositions and kits for analyzing a chemical analyte using an electrochemical cell connected to a measuring apparatus are provided. The electrochemical cell contains a solution having one or more conductive or redox active NPs (nanoparticles), one or more chemical analytes, and an indicator. In addition, the electrochemical cell contains one or more electrodes in communication with the solution. One or more catalytic ECL properties are generated by the interaction of the one or more conductive or redox active NPs and the liquid sample and measured at the one or more electrodes or with an optical detection system.