Abstract: Provided is a noise reduction method of a lightmap, including: obtaining a lightmap (202); determining, by using each pixel in the lightmap as a target pixel, a noise reduction reference region corresponding to the target pixel in the lightmap, the noise reduction reference region including a reference pixel for noise reduction reference (204); determining a distance in three-dimensional space between the reference pixel and the target pixel (206); determining a light contribution parameter value of the reference pixel to the target pixel based on the distance (208); obtaining light data recorded for the reference pixel in the lightmap (210); and performing, based on the light contribution parameter value and the light data of the reference pixel, noise reduction on light data recorded for the target pixel in the lightmap, to obtain a noise-reduced lightmap (212).

Abstract: What is described herein relates to a method for separating host cell proteins from proteins of interest, comprising the following steps a) subjecting a mixture of host cell proteins and proteins of interest to at least a Protein A chromatography followed by a cation exchange chromatography (CEX) and up to two ion exchange chromatography (IEX) steps wherein one of the two ion exchange chromatography steps is a mixed mode chromatography (MM AEX/CEX) and the other one is an anion exchange membrane adsorber (MA AEX) in flow through mode OR b) subjecting a mixture of host cell proteins and proteins of interest to non-ionic detergent during a Protein A chromatography wash step.

Abstract: In a method, a longitudinal angle, an azimuthal angle, illumination information, and color information of a pixel in a hair area of a virtual image corresponding to each optical path of a virtual main light source are obtained. For each optical path of the virtual main light source, a respective longitudinal scattering amount is determined based on the longitudinal angle and the illumination information of the pixel, a respective azimuthal scattering amount is determined based on the azimuthal angle of the pixel, and a respective scattering amount of the pixel corresponding to the respective optical path is determined according to the longitudinal scattering amount, the azimuthal scattering amount, and the color information of the pixel. Scattering amounts of the pixel corresponding to the optical paths of the virtual main light source are fused to obtain first coloring information of the pixel corresponding to the virtual main light source.

Abstract: A rotary joint, including: a hydraulic follow-up mechanism and a rotary transmission mechanism. The hydraulic follow-up mechanism includes a cylinder body, a valve sleeve, a valve core, a valve body, a left end cover and a right end cover. The rotary transmission mechanism includes a tray, a stabilizing ring, a follow-up disk, a torque transfer disk and a stable supporting wheel mechanism. The left end cover and the right end cover are arranged at the left and right ends of the cylinder body, respectively. The valve body is concentrically mounted in a cylindrical hollow chamber of the cylinder body. The output shaft at the right end of the valve body projects out of the right end cover. The right end of the valve core is provided with a valve core torque transfer shaft extending rightwards through the right end of the valve body.

Abstract: We demonstrate herein that neuritin controls the homeostasis of regulatory T cells in an antigen dependent manner. Based on this discovery, we describe herein the application of neuritin as a therapeutic agent to manipulate antigen specific regulatory T cells in various disease settings is described. Thus manipulation of Treg cells and DCs through neuritin can be used to enhance immunotherapy of autoimmune diseases, cancer and infectious diseases, as well as enhance lymphocyte engraftment in settings of donor lymphocyte infusion, bone marrow transplant, as well as other types of transplants, and adoptive transfer.

Abstract: A rotary joint, including: a hydraulic follow-up mechanism and a rotary transmission mechanism. The hydraulic follow-up mechanism includes a cylinder body, a valve sleeve, a valve core, a valve body, a left end cover and a right end cover. The rotary transmission mechanism includes a tray, a stabilizing ring, a follow-up disk, a torque transfer disk and a stable supporting wheel mechanism. The left end cover and the right end cover are arranged at the left and right ends of the cylinder body, respectively. The valve body is concentrically mounted in a cylindrical hollow chamber of the cylinder body. The output shaft at the right end of the valve body projects out of the right end cover. The right end of the valve core is provided with a valve core torque transfer shaft extending rightwards through the right end of the valve body.

Abstract: The present invention provides a method for determining the nucleic acid composition in a total nucleic acid mixture comprising a first nucleic acid and a second nucleic acid. The method comprises: 1) treating the total nucleic acid mixture with a bisulfate, to convert the non-methylated cytosine in the total nucleic acid mixture into uracil, and obtain a converted total nucleic acid mixture; 2) subjecting the converted total nucleic acid mixture to multiplexed fluorescent quantitative PCR using a first set of amplification primers and a second set of amplification primers; and 3) based on the ratio R of the methylated amplification product to the non-methylated amplification product of the predetermined nucleic acid fragment, a methylation proportion M1 of the predetermined nucleic acid fragment in the first nucleic acid, and a methylation proportion M2 of the predetermined nucleic acid fragment in the second nucleic acid, determining the nucleic acid composition in the total nucleic acid mixture.

Abstract: The present invention provides a method for determining the nucleic acid composition in a total nucleic acid mixture comprising a first nucleic acid and a second nucleic acid. The method comprises: 1) treating the total nucleic acid mixture with a bisulfate, to convert the non-methylated cytosine in the total nucleic acid mixture into uracil, and obtain a converted total nucleic acid mixture; 2) subjecting the converted total nucleic acid mixture to multiplexed fluorescent quantitative PCR using a first set of amplification primers and a second set of amplification primers; and 3) based on the ratio R of the methylated amplification product to the non-methylated amplification product of the predetermined nucleic acid fragment, a methylation proportion M1 of the predetermined nucleic acid fragment in the first nucleic acid, and a methylation proportion M2 of the predetermined nucleic acid fragment in the second nucleic acid, determining the nucleic acid composition in the total nucleic acid mixture.

Abstract: Provided are a method, system, and computer-readable medium for determining whether a copy number variation exists in a sample genome. The method includes sequencing a sample genome to obtain a sequencing result formed by multiple reads; comparing the sequencing result with a reference genome sequence to determine the distribution of the reads on the reference genome sequence; determining, based on the distribution of the reads on the reference genome sequence, multiple breakpoints on the reference genome sequence, wherein the number of the reads on either side of each breakpoint are significantly different; determining, based on the plurality of breakpoints, a detection window on the reference genome; determining, based on the reads falling in the detection window, a parameter; and determining, based on the difference between the first parameter and a preset threshold, whether a copy number variation exists in the sample genome against the detection window.

Abstract: The present invention relates to a method for detecting genetic variation, comprising the following steps: acquiring reads from a test sample; aligning said reads with a reference genome sequence; dividing said reference genome sequence into windows, calculating the number of said reads which are aligned to each window, and acquiring the statistic for each window on the basis of the number of said reads; and for a fragment of the reference genome sequence, acquiring the genetic variation sites on the basis of the change in the statistics of all the windows thereon in the fragment of the reference genome sequence.

Abstract: The present invention relates to the field of genomic mutation detection, and in particular, to the detection of the copy number variation (CNV) in cellular chromosomal DNA fragments. The present invention also relates to the detection of diseases related to the copy number variation in the cellular chromosomal DNA fragments.

Abstract: We demonstrate herein that neuritin controls the homeostasis of regulatory T cells in an antigen dependent manner. Based on this discovery, we describe herein the application of neuritin as a therapeutic agent to manipulate antigen specific regulatory T cells in various disease settings is described. Thus manipulation of Treg cells and DCs through neuritin can be used to enhance immunotherapy of autoimmune diseases, cancer and infectious diseases, as well as enhance lymphocyte engraftment in settings of donor lymphocyte infusion, bone marrow transplant, as well as other types of transplants, and adoptive transfer.