Abstract: A vulcanizable rubber composition comprising a rubber component including (a) natural rubber, (b) functionalized, synthetic polyisoprene, and (c) optionally a butadiene-based synthetic rubber; a silica filler; and curative.

Abstract: A PD-L1 antigen binding protein and an application thereof. The antigen binding protein has one or more of the following properties: binding to a PD-L1 protein at an EC50 value of 0.07 ?g/ml or above; blocking binding between the PD-L1 protein and a PD-1 protein; promoting the activation of a T cell; and inhibiting the volume increase of the in vivo tumor. An application of the antigen binding protein in the preparation of a drug for treating tumor.

Abstract: Embodiments of the present disclosure are directed to rubber formulations, wherein the rubber formulations comprise functionalized conjugated diene polymer, natural rubber, and reinforcing filler comprising at least one of silica and carbon black. The functionalized conjugated diene polymer has a functional group, a vinyl content greater than or equal to 50%, and a weight average molecular weight Mw of about 75,000 g/mol to about 1,000,000 g/mol.

Abstract: A T cell product for administration to a subject and a use thereof are provided. The product includes at least one allogeneic T cell, which expresses at least one MHC molecule identified as an exogenous source by at least one T cell of the subject. The T cell product can widen the range of a donor and activate an immune response of the subject. The T cell product is used in the preparation of a drug for treating tumors.

Abstract: Provided is an isolated antigen-binding protein, which can specifically bind to CD73 and includes at least one CDR in a heavy chain variable region VH, wherein the region VH includes an amino acid sequence as represented by SEQ ID NO: 49.

Abstract: Provided is an isolated antigen-binding protein, capable of binding to CD73. The isolated antigen-binding protein contains HCDR3, and the HCDR3 comprises an amino acid sequences as shown in SEQ ID No.:3. Also provided are a preparation method for the antigen-binding protein, and an application of the antigen-binding protein.

Abstract: Provided in the present application are an anti-PD-L1/TGF-? bispecific antibody and the use thereof. Specifically, provided in the present application is a bifunctional antibody, which comprises: (a) an anti-PD-L1 antibody or element; and (b) an anti-TGF-? antibody or element connected to the anti-PD-L1 antibody or element. The bifunctional antibody of the present application can simultaneously bind to TGF-? and PD-L1, thereby exerting a therapeutic effect on TGF-? and PD-L1-positive tumor cells.

Abstract: The present application provides an antibody targeting interleukin 36R, a preparation method therefor, and an application thereof. Specifically, the present application provides an IL-36R antibody having high affinity and high bioactivity. The antibody can bind to IL-36R with high affinity, and can block the binding between an IL-36R ligand (?, ?. ?) and the IL-36R and a signal path activated by the IL-36R ligand, thereby treating and/or preventing IL-36 related diseases.

Abstract: Provided is a separated antigen-binding protein. The antigen-binding protein comprises at least one CDR in a heavy chain variable region VH, and the VH comprises an amino acid sequence shown in SEQ ID NO: 55. Also provided are an anti-TIGIT antibody, and a preparation method and an application thereof. The antigen-binding protein can specifically bind with a TIGIT antigen to block the binding of TIGIT and a ligand thereof, and can be used for preparing drugs for preventing or treating TIGIT-related diseases.

Abstract: Provided are a sequencing library and applications thereof. The provided sequencing library includes a first nucleic acid molecule and a second nucleic acid molecule. The first nucleic acid molecule carries a cell index sequence and a droplet index sequence. The second nucleic acid molecule carries an insert fragment and a cell index sequence.

Abstract: The present disclosure describes a system, method and software applications for predicting the KAM of a subject for a plurality of gait cycles of a subject. At least one sensor attachable adjacent to the ankle of at least one leg of the subject provides accelerometer and gyroscopic data for the plurality of gait cycles. A processing means receives subject parameters and accelerometer and gyroscopic data from the at least one sensor for evaluation by a neural network of predicted KAM values for the plurality of gait cycles of the subject. The neural network is configured via determining KAM values for each of the plurality of subjects from measurements during a plurality of gait cycles and other parameters.

Abstract: The present disclosure describes a system, method and software applications for predicting the KAM of a subject for a plurality of gait cycles of a subject. At least one sensor attachable adjacent to the ankle of at least one leg of the subject provides accelerometer and gyroscopic data for the plurality of gait cycles. A processing means receives subject parameters and accelerometer and gyroscopic data from the at least one sensor for evaluation by a neural network of predicted KAM values for the plurality of gait cycles of the subject. The neural network is configured via determining KAM values for each of the plurality of subjects from measurements during a plurality of gait cycles and other parameters.