Abstract: Aspects of the disclosed technology comprise generating firewall rules based on traffic, outputting the generated firewall rules to an output file, and using the output file to set firewall rules in a network. The firewall rules may be generated without a priori knowledge of the network; alternatively no firewall rules are required. Generated rules may be tuned for user preferences to adjust for the number of generated firewall rules, and their over or under inclusiveness to non-historic traffic data.

Abstract: The present invention relates to four crystal forms of crisaborole in free form and the preparation method thereof. The present invention also relates to the pharmaceutical composition containing the crystal forms and the use thereof.

Abstract: Disclosed herein are methods and compounds for inducing DDB1- and CUL4-associated factor 16 (DCAF16)-mediated protein degradation in mammalian cells. In some embodiments, also disclosed herein are methods of modulating the substrate selectivity of a DCAF16-CUL4-RBX1-DDB1 complex (CRL4) for modulating protein degradation.

Abstract: The present invention relates to crystalline forms of a sulfonamide compound and processes for preparing the same. The present invention provides five Crystalline Forms B, C, D, E, and F of the compound of formula (I), and processes for preparing the same and uses thereof. The prevent invention also provides processes for preparing the Crystalline Form A. Crystalline Forms B, C, D, E, and F of the compound of formula (I) provided by the present invention have the advantages in at least one of solubility, melting point, stability, dissolution, hygroscopicity, adhesion, fluidity, biological effectiveness, processing performance, purification, formulation production, safety, and the like, which provides a new and better choice for the preparation of pharmaceutical formulations containing the compound of formula (I), and has a very important significance for the drug development.

Abstract: A disclosed method for developing and testing a hyper-converged infrastructure (HCI) platform creates a snapshot pool with one or more virtual resource snapshots that include one or more virtual node snapshots, one or more virtual cluster snapshots, or both. The snapshot pool may be maintained with a desired quantity of the virtual resource snapshots by adjusting the composition of the snapshot pool in response to snapshot events, including an event that alters either a composition of the snapshot pool or a configuration of the HCI platform. The desired quantity of virtual resource snapshots may be determined in accordance with one or more snapshot thresholds. The snapshot thresholds may include a snapshot pertaining to a quantity of virtual node snapshots in the snapshot pool and/or a snapshot pertaining to a quantity of virtual cluster snapshots. Specifically, the threshold may include a cluster maximum and minimum and a node maximum and minimum.

Abstract: Disclosed methods define VLAN time slots for one or more VLANs within an HCI environment. A management resource may control virtual application access to each VLAN in accordance with the VLAN time slots wherein only one virtual application may connect to the VLAN during a VLAN time slot. Disclosed methods may define VLAN time slots for each of the plurality of virtual applications. The VLAN time slots may be defined dynamically, wherein durations of the VLAN time slots may be re-calculated each VLAN cycle. A duration of the VLAN time slot for a particular virtual application may be determined based on the number of packets transmitted by the virtual application during a previous VLAN cycle. Each VLAN time slot may include an active interval, for transmitting packets, and an inactive interval. Each active interval may include a fixed duration base interval and a variable duration dynamic interval.

Abstract: The present disclosure is directed to novel crystalline forms of ozanimod and ozanimod hydrochloride, as well as preparation method thereof. Said crystalline forms of ozanimod and ozanimod hydrochloride can be used for treating autoimmune diseases, particularly used for preparing drugs for treating multiple sclerosis and ulcerative colitis. The crystalline forms of the present disclosure have one or more advantages in solubility, melting point, stability, dissolution, bioavailability and processability and provide new and better choices for the preparation of ozanimod drug product, and are very valuable for drug development.

Abstract: A multilayer film includes a substrate; a first magnetic layer disposed on the substrate and a second magnetic layer disposed on the first magnetic layer. The first magnetic layer includes Fe(50-80)N(10-20)B(1-20)M(0-10), wherein M is Si, Ta, Zr, Ti, Co, or a combination thereof. The second magnetic layer includes Fe(50-90)N(10-50) or Fe(60-90)N(1-10)Ta(5-30). The multilayer magnetic film has, over a frequency range of 50 MHz to 10 GHz, a magnetic permeability of greater than or equal to 1800 over a selected frequency band in the frequency range; a magnetic loss tangent of less than or equal to 0.3 over a selected frequency band in the frequency range; and a cutoff frequency of greater than or equal to 1 GHz, or greater than or equal to 2 GHz.

Abstract: The present disclosure relates to crystalline form CS1 and CS9 of a hypoxia-inducible factor prolyl hydroxylase inhibitor compound (I) GSK1278863, processes for preparation, and uses for preparing drugs treating and/or preventing anemia thereof.

Abstract: This invention relates to compositions and methods for modifying Ubiquitin Binding Peptidase (DA1) genes in plants, optionally to improve yield traits. The invention further relates to plants having increased improved yield traits produced using the methods and compositions of the invention.

Abstract: A multi-frequency ultrasound therapy apparatus is configured to operate at its center frequency and at the higher harmonic of its center frequency. The center frequency can be for the entire apparatus or for each ultrasound source element. At least one source element can generate ultrasound energy at its center frequency while, simultaneously, at least another source element can generate ultrasound energy at the higher harmonic of its center frequency. In addition, the same source element can generate ultrasound energy at its center frequency and the higher harmonic of its center frequency, respectively, but at different times. A data storage unit that stores encrypted and encoded data is disposed on the apparatus. The encoded data includes a unique identification code of the apparatus, the condition of use of the apparatus, the center frequency of each source element, the ultrasound efficiency of each source element, and/or other parameters relating to the apparatus.

Abstract: This invention relates to compositions and methods for modifying Cytokinin Receptor Histidine Kinase (HK) genes in plants, optionally to improve yield traits. The invention further relates to plants having increased improved yield traits produced using the methods and compositions of the invention.

Abstract: The present invention is directed to regimens for administering one or more Antibody-Based Molecules that bind PD-1 or PD-L1, and LAG-3 (e.g, a PD-1×LAG-3 bispecific molecule) alone, or in combination with an Antibody-Based Molecule that binds a Tumor Antigen (TA) for the treatment of cancer. The invention particularly concerns the use of such regimens in conjunction with PD-1×LAG-3 bispecific molecules. The invention is directed to the use of such molecules, and to the use of pharmaceutical compositions and pharmaceutical kits that contain such molecules and that facilitate the use of such dosing regimens in the treatment of cancer.

Abstract: Disclosure is an aerosol generating article having a low temperature burning heat source, including a low temperature burning smoking set and a matching cigarette, the smoking set includes a heat insulation sleeve, an annular heat conductive barrel, a cover and a heat source cigarette lighter; the barrel is provided in an annular mounting groove at a left section of an inner wall of the sleeve, the cover is provided at a left end of the sleeve, a cavity of the barrel is filled with the heat source in a sealed manner; a plurality of electric heating columns are provided at a right end of the lighter; the cover is provided with a plurality of insertion holes, and after the plurality of electric heating columns are inserted into the plurality of insertion holes, the lighter gets in contact with the barrel to ignite the heat source in the barrel.

Abstract: The present disclosure discloses a Single-Event Transient (SET) pulse measuring circuit capable of eliminating impact thereof, and an integrated circuit chip. The SET pulse measuring circuit capable of eliminating impact thereof includes four parts: a SET pulse test chain, a latch circuit, a flip-flop test circuit, a latching self-trigger circuit. The integrated circuit chip is provided with a test chain module and two sets of SET pulse measuring circuits capable of eliminating impact thereof, and inputs of the two sets of SET pulse measuring circuits capable of eliminating impact thereof are the same and each are connected to an output terminal of the test chain module.

Abstract: A multi-frequency ultrasound therapy apparatus is configured to operate at its center frequency and at the higher harmonic of its center frequency. The center frequency can be for the entire apparatus or for each ultrasound source element. At least one source element can generate ultrasound energy at its center frequency while, simultaneously, at least another source element can generate ultrasound energy at the higher harmonic of its center frequency. In addition, the same source element can generate ultrasound energy at its center frequency and the higher harmonic of its center frequency, respectively, but at different times. A data storage unit that stores encrypted and encoded data is disposed on the apparatus. The encoded data includes a unique identification code of the apparatus, the condition of use of the apparatus, the center frequency of each source element, the ultrasound efficiency of each source element, and/or other parameters relating to the apparatus.

Abstract: A system for simulating network configurations includes data processing hardware and memory hardware in communication with the data processing hardware. The memory hardware stores instructions that when executed on the data processing hardware cause the data processing hardware to perform operations. The operations includes receiving one or more parameter changes for a production network model of a network. The operations also include generating a simulation network model including the one or more parameter changes. Another operation includes analyzing the simulated network flow within the simulation network model. The operations also include generating a report including an impact of the parameter changes on the network. The operations may also include receiving a production network log including a recorded workflow for the production network model and simulating the production workflow of the production network log within the simulation network model to generate a simulated network log.

Abstract: An order management method applied to an electric vehicle is provided. An order allocation apparatus at a platform obtains information about each commercial vehicle and a location of a safe point. The information about the vehicle includes information about an electric commercial vehicle, for example, a current location and a remaining power of the vehicle. The order allocation apparatus selects a service vehicle for a passenger. When the service vehicle is the electric vehicle, it is ensured that a remaining power of the service vehicle is sufficient to complete a safe driving route, and the safe driving route is a route connecting a current location of the candidate vehicle, a start location, a destination location, and a location of a safe point closest to the destination location. The order allocation apparatus allocates an order to the service vehicle.

Abstract: A method for catalytic cracking of naphtha is provided. Naphtha is catalytically cracked under the action of a catalyst. The catalyst includes aluminosilicate, alkali metal oxide, alkaline earth metal oxide, TiO2, iron oxide, vanadium oxide and nickel oxide. On the other hand, a rapid separation component is arranged in a disengager of a catalytic cracking reaction device, so that a transport disengaging height is greatly reduced without changing a gas flow and a diameter of the disengager. In addition, the separation efficiency of oil gas and the catalyst is improved.