Patents by Inventor Xiaoyue LI

Xiaoyue LI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of 4-bromo-2-(4?-ethoxyphenyl)-1-chlorobenzene
    Patent number: 11565990
    Abstract: A more environmentally friendly synthesis method of 4-bromo-2-(4?-ethoxyphenyl)-1-chlorobenzene with simplified steps provides a more effective synthetic strategy for producing key intermediates of SGLT-2 inhibitors such as dapagliflozin, sotagliflozin, and ertugliflozin. In the presence of trifluoroacetic anhydride, 5-bromo-2-chlorobenzoic acid and phenetole are selected to complete a direct acylation reaction under the catalysis of boron trifluoride diethyl etherate, and triethylsilane is added thereinto without treatment for one-pot reaction to obtain a target compound 4-bromo-2-(4?-ethoxyphenyl)-1-chlorobenzene.
    Type: Grant
    Filed: June 9, 2021
    Date of Patent: January 31, 2023
    Assignee: WISDOM PHARMACEUTICAL CO., LTD
    Inventors: Lin Hu, Tao Xu, Xiaolong Qiu, Xiaoyue Li, Zhiwei Zuo, Wenbo Liu, Lingling Chu, Ximeng Yuan, Ping Zou
  • PREPARATION OF 4-BROMO-2-(4'-ETHOXYPHENYL)-1-CHLOROBENZENE
    Publication number: 20220267238
    Abstract: A more environmentally friendly synthesis method of 4-bromo-2-(4?-ethoxyphenyl)-1-chlorobenzene with simplified steps provides a more effective synthetic strategy for producing key intermediates of SGLT-2 inhibitors such as dapagliflozin, sotagliflozin, and ertugliflozin. In the presence of trifluoroacetic anhydride, 5-bromo-2-chlorobenzoic acid and phenetole are selected to complete a direct acylation reaction under the catalysis of boron trifluoride diethyl etherate, and triethylsilane is added thereinto without treatment for one-pot reaction to obtain a target compound 4-bromo-2-(4?-ethoxyphenyl)-1-chlorobenzene.
    Type: Application
    Filed: June 9, 2021
    Publication date: August 25, 2022
    Applicant: WISDOM PHARMACEUTICAL CO., LTD
    Inventors: Lin HU, Tao XU, Xiaolong QIU, Xiaoyue LI, Zhiwei ZUO, Wenbo LIU, Lingling CHU, Ximeng YUAN, Ping ZOU