Abstract: In some embodiments, the subject matter of this disclosure relates to systems and methods for designing and conducting clinical trials and biomarker validation studies. An example method includes: obtaining access to a trained computer-implemented model; providing, to the trained computer-implemented model, a plurality of sets of values for a plurality of features, each set of values corresponding to a candidate individual from a set of candidate individuals; receiving, from the trained computer-implemented model, a prediction of a disease state for each set of values; identifying, from the predictions of the disease state, a group of participants from the set of candidate individuals; and facilitating at least one of a clinical trial or a biomarker validation study involving the group of participants.

Abstract: The present disclosure discloses an ultra-precision machining method, including determining a total material removal amount based on a product to be machined and a blank, and performing rough machining to complete a material removal amount of the rough machining; after the rough machining, establishing an ultra-precision machining error prediction model by using an existing machining error, and predicting a semi-finishing error; re-establishing an ultra-precision machining error prediction model considering influence of the semi-finishing error; and finally performing finishing process planning. In the ultra-precision machining method according to the present disclosure, influence of the finishing error is considered, the ultra-precision machining error prediction model is re-established, and by integrated optimization of process parameters of the semi-finishing and the finishing, machining precision of ultra-precision machining is further improved without reducing machining efficiency.

Abstract: A method includes determining a position of a wearable electronic device relative to the transportation device, detecting an event in which the transportation device has contacted an external object, and in response, obtaining user state information from the wearable electronic device.

Abstract: A computer system is used to initiate a process to configure an external accessory for use with at least a first device management application. The computer system displays a prompt that includes an option to initiate a process to configure the external accessory for use with at least a first device management application. While displaying the prompt, the computer system optionally receives a selection and/or an input corresponding to a selection of an option to initiate a process to configure the external accessory for use with at least a first device management application.

Abstract: The present disclosure generally relates to user interfaces for enabling an activity using a computer system. In some embodiments, exemplary user interfaces for invoking an activity associated with an application are described. In some embodiments, exemplary user interfaces for customizing displayed content based on circumstances under which the content was invoked are described. In some embodiments, exemplary user interfaces for managing applications that were used to enable activities are described. In some embodiments, exemplary user interfaces for managing settings for applications used to enable activities are described.

Abstract: In an example method, a mobile device obtains a database including a plurality of data records. Each data record includes an indication of a respective impact previously experienced by a user of the mobile device, and sensor data generated by one or more first sensors worn by the user during that impact. The mobile device obtains sensor data generated by one or more second sensors worn by the user over a period of time, and determines whether the user has fallen during the period of time based on the database and the additional sensor data. The mobile device generates one or more notifications based on the determination of whether the user has fallen during the period of time.

Abstract: In an example method, a mobile device receives motion data obtained by one or more sensors over a time period, where the one or more sensors are worn by a user, The mobile device determines, based on the motion data, an impact experienced by the user during the time of period, and determines one or more of characteristics of the user. The mobile device determines, based on the motion data and the one or more characteristics of the user, a likelihood that the user requires assistance subsequent to the impact, and generates one or more notifications based on likelihood.

Abstract: The present disclosure generally relates to user interfaces for enabling an activity using a computer system. In some embodiments, exemplary user interfaces for invoking an activity associated with an application are described. In some embodiments, exemplary user interfaces for customizing displayed content based on circumstances under which the content was invoked are described. In some embodiments, exemplary user interfaces for managing applications that were used to enable activities are described. In some embodiments, exemplary user interfaces for managing settings for applications used to enable activities are described.

Abstract: In an example method, a mobile device receives motion data obtained by one or more sensors over a time period, where the one or more sensors are worn by a user, The mobile device determines, based on the motion data, an impact experienced by the user during the time of period, and determines one or more of characteristics of the user. The mobile device determines, based on the motion data and the one or more characteristics of the user, a likelihood that the user requires assistance subsequent to the impact, and generates one or more notifications based on likelihood.

Abstract: The invention provides compounds of Formula (I), immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat diseases or disorders associated with Toll-Like Receptor 7 activity.

Abstract: In an example method, a mobile device obtains a database including a plurality of data records. Each data record includes an indication of a respective impact previously experienced by a user of the mobile device, and sensor data generated by one or more first sensors worn by the user during that impact. The mobile device obtains sensor data generated by one or more second sensors worn by the user over a period of time, and determines whether the user has fallen during the period of time based on the database and the additional sensor data. The mobile device generates one or more notifications based on the determination of whether the user has fallen during the period of time.

Abstract: The invention provides compounds of Formula (I), immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat diseases or disorders associated with Toll-Like Receptor 7 activity.

Abstract: The invention provides compounds of Formula (I), immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat diseases or disorders associated with Toll-Like Receptor 7 activity.

Abstract: Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminum salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.

Abstract: The invention provides compounds of Formula (I), immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat diseases or disorders associated with Toll-Like Receptor 7 activity.

Abstract: The invention provides a compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat diseases or disorders associated with Toll-Like Receptor 7 activity.

Abstract: The invention provides a compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat diseases or disorders associated with Toll-Like Receptor 7 activity.

Abstract: The invention provides a compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat diseases or disorders associated with Toll-Like Receptor 7 activity.

Abstract: The invention provides a compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat diseases or disorders associated with Toll-Like Receptor 7 activity.

Abstract: Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.