Abstract: Provided is an isolated antigen-binding protein, which can specifically bind to CD73 and includes at least one CDR in a heavy chain variable region VH, wherein the region VH includes an amino acid sequence as represented by SEQ ID NO: 49.

Abstract: A grill device is for cooking a fluidic food material, and includes an upper grill unit and a lower grill unit. The lower grill unit includes a lower grill plate. The upper grill unit removably covers and is operable to uncover the lower grill unit, and includes an upper grill plate that cooperates with the lower grill plate to define a cooking space therebetween, which is adapted to accommodate the fluidic food material when cooking, and that defines an opening, which is in spatial communication with the cooking space and which is adapted to permit the fluidic food material to flow into the cooking space therethrough.

Abstract: A grill device for cooking a fluidic food material includes a lower grill plate and an upper grill plate. The lower grill plate includes a lower base wall and a lower surrounding wall that extends upwardly from the lower base wall. The lower base wall has at least one lower inclined surface. The upper grill plate removably covers and is operable to uncover the lower grill plate. The upper grill plate cooperates with the lower grill plate to define a cooking space therebetween, and is formed with an opening through which the fluidic food material is fed into the cooking space. The lower inclined surface is for guiding the fluidic food material to flow smoothly and then fill up the cooking space.

Abstract: A grilling apparatus includes a case unit and a feeding seat. The case unit has a containing recess for detachably receiving the feeding seat.

Abstract: A grill device for cooking a fluidic food material includes a lower grill plate and an upper grill plate. The lower grill plate includes a lower base wall and a lower surrounding wall that extends upwardly from the lower base wall. The lower base wall has at least one lower inclined surface. The upper grill plate removably covers and is operable to uncover the lower grill plate. The upper grill plate cooperates with the lower grill plate to define a cooking space therebetween, and is formed with an opening through which the fluidic food material is fed into the cooking space. The lower inclined surface is for guiding the fluidic food material to flow smoothly and then fill up the cooking space.

Abstract: A grill device is for cooking a fluidic food material, and includes an upper grill unit and a lower grill unit. The lower grill unit includes a lower grill plate. The upper grill unit removably covers and is operable to uncover the lower grill unit, and includes an upper grill plate that cooperates with the lower grill plate to define a cooking space therebetween, which is adapted to accommodate the fluidic food material when cooking, and that defines an opening, which is in spatial communication with the cooking space and which is adapted to permit the fluidic food material to flow into the cooking space therethrough.

Abstract: Microfluidic devices having active features such as valves, peristaltic pumps, and mixing portions are fabricated to have a thin elastomeric membrane over the active features. The active features are activated by a tactile actuator external to the membrane, for example, a commercial Braille display. The display may be computer controlled, for example by simple text editor software, to activate individual Braille protrusions or a plurality of protrusions to actuate the active portions of the microfluidic device. Integral devices can incorporate the tactile actuators in a single device, but still external to the membrane.

Abstract: Microfluidic devices for cell culturing and methods for using the same are disclosed. One device includes a substrate and membrane. The substrate includes a reservoir in fluid communication with a passage. A bio-compatible fluid may be added to the reservoir and passage. The reservoir is configured to receive and retain at least a portion of a cell mass. The membrane acts as a barrier to evaporation of the bio-compatible fluid from the passage. A cover fluid may be added to cover the bio-compatible fluid to prevent evaporation of the bio-compatible fluid.

Abstract: Microfluidic devices for cell culturing and methods for using the same are disclosed. One device includes a substrate and membrane. The substrate includes a reservoir in fluid communication with a passage. A bio-compatible fluid may be added to the reservoir and passage. The reservoir is configured to receive and retain at least a portion of a cell mass. The membrane acts as a barrier to evaporation of the bio-compatible fluid from the passage. A cover fluid may be added to cover the bio-compatible fluid to prevent evaporation of the bio-compatible fluid.

Abstract: Microfluidic devices having active features such as valves, peristaltic pumps, and mixing portions are fabricated to have a thin elastomeric membrane over the active features. The active features are activated by a tactile actuator external to the membrane, for example, a commercial Braille display. The display may be computer controlled, for example by simple text editor software, to activate individual Braille protrusions or a plurality of protrusions to actuate the active portions of the microfluidic device. Integral devices can incorporate the tactile actuators in a single device, but still external to the membrane.

Abstract: Microfluidic devices having active features such as valves, peristaltic pumps, and mixing portions are fabricated to have a thin elastomeric membrane over the active features. The active features are activated by a tactile actuator external to the membrane, for example, a commercial Braille display. The display may be computer controlled, for example by simple text editor software, to activate individual Braille protrusions or a plurality of protrusions to actuate the active portions of the microfluidic device. Integral devices can incorporate the tactile actuators in a single device, but still external to the membrane.

Abstract: A microfluidic system employs a microchannel and a gravity driven pump comprising horizontally oriented fluid supply reservoirs which supplies fluid to the microchannel at a substantially constant rate. The device is useful for numerous microfluidic applications, for example in the culture and/or treatment of biological systems under constant flow-induced stress, cell-size sorting, motile sperm sorting, or embryo culture.

Abstract: Nanopatterned devices are easily fabricated, over large surface areas when desired, by forming a multilayer article of deformable substrate, brittle layer, and coating layer, and deforming the multilayer film such that a plurality of cracks are formed therein. The cracks have different physicochemical properties than the non-cracked coating layer, and advantageously serve as attachment points for culturing microorganisms.

Abstract: Microfluidic devices having active features such as valves, peristaltic pumps, and mixing portions are fabricated to have a thin elastomeric membrane over the active features. The active features are activated by a tactile actuator external to the membrane, for example, a commercial Braille display. The display may be computer controlled, for example by simple text editor software, to activate individual Braille protrusions or a plurality of protrusions to actuate the active portions of the microfluidic device. Integral devices can incorporate the tactile actuators in a single device, but still external to the membrane.

Abstract: Nanopatterned devices are easily fabricated, over large surface areas when desired, by forming a multilayer article of deformable substrate, brittle layer, and coating layer, and deforming the multilayer film such that a plurality of cracks are formed therein. The cracks have different physicochemical properties than the non-cracked coating layer, and advantageously serve as attachment points for culturing microorganisms.

Abstract: A microfluidic system employs a microchannel and a gravity driven pump comprising horizontally oriented fluid supply reservoirs which supplies fluid to the microchannel at a substantially constant rate. The device is useful for numerous microfluidic applications, for example in the culture and/or treatment of biological systems under constant flow-induced stress, cell-size sorting, motile sperm sorting, or embryo culture.