Patents by Inventor Xiaoyun Wu

Xiaoyun Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250034583
    Abstract: This invention relates to compositions and methods for modifying a PUF gene in plants, optionally to improve yield traits. The invention further relates to plants having increased improved yield traits produced using the methods and compositions of the invention.
    Type: Application
    Filed: July 25, 2024
    Publication date: January 30, 2025
    Inventors: Devin Lee O’Connor, Jennifer Louise Modliszewski, HaeJin Kim, Xiaoyun Wu
  • Patent number: 12206121
    Abstract: The present application discloses an improved aluminum cover plate of a battery, including a cover plate, a metal sheet and an electrode column. The electrode column penetrates and is arranged in rivet holes of the cover plate and the metal sheet, and is riveted with the metal sheet. A first sealing ring is arranged between a cap portion and a nail portion of the electrode column and the cover plate. A second sealing ring is arranged on an outer periphery of the nail portion of the electrode column, and the second sealing ring is clamped and arranged between the cover plate and the metal sheet. The first sealing ring and the second sealing ring are arranged separately.
    Type: Grant
    Filed: December 9, 2021
    Date of Patent: January 21, 2025
    Assignee: LINKDATA NEW ENERGY CO., LTD.
    Inventors: Xiaxia Liao, Xiaoyun Zhang, Sitao Yang, Jun Wu
  • Publication number: 20240392004
    Abstract: The present application relates to immunomodulatory molecules comprising a first binding domain (e.g., immunostimulatory cytokine such as IL-2 or IL-12 or variant thereof) specifically recognizing a first target molecule (e.g., receptor of immunostimulatory cytokine) and a second binding domain (e.g., agonist ligand such as PD-L1 or PD-L2 or variant thereof, or agonist antigen-binding fragment such as anti-PD-1 agonist Fab, scFv, VHH, or full-length antibody) specifically recognizing a second target molecule (e.g., inhibitory checkpoint molecule such as PD-1), wherein the first binding domain upon binding to the first target molecule up-regulates an immune response, and wherein the second, binding domain upon binding to the second target molecule down-regulates the immune response. Methods of making and uses of such immunomodulatory molecules are also provided.
    Type: Application
    Filed: March 10, 2022
    Publication date: November 28, 2024
    Inventors: Ellen WU, Xiaoyun WU, John WAKEFIELD
  • Publication number: 20240366620
    Abstract: The present invention features improved compounds, especially methods of identifying patients having cancer using biomarkers (e.g., PDE3A, SLFN12 and/or CREB3L1) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., Compounds 1-6 disclosed herein).
    Type: Application
    Filed: July 6, 2024
    Publication date: November 7, 2024
    Applicants: BAYER PHARMA AKTIENGESELLSCHAFT, THE BROAD INSTITUTE, INC., DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: TIMOTHY A. LEWIS, ALEX BURGIN, MONICA SCHENONE, XIAOYUN WU, HEIDI GREULICH, MATTHEW MEYERSON, LUC DE WAAL, ANTJE MARGRET WENGNER, KNUT EIS, PHILIP LIENAU, ULRIKE SACK, MARTIN LANGE
  • Publication number: 20240279311
    Abstract: The present application provides an antibody fusion protein comprising a vascular endothelial growth factor receptor (VEGFR) fused to the C-terminus of the antibody light chain. Also provided are methods of making and using these antibody fusion proteins.
    Type: Application
    Filed: January 17, 2024
    Publication date: August 22, 2024
    Inventor: Xiaoyun WU
  • Patent number: 12053476
    Abstract: The present invention features improved compounds, especially methods of identifying patients having cancer using biomarkers (e.g., PDE3A, SLFN12 and/or CREB3L1) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., Compounds 1-6 disclosed herein).
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: August 6, 2024
    Assignees: Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Timothy A. Lewis, Alex Burgin, Monica Schenone, Xiaoyun Wu, Heidi Greulich, Matthew Meyerson, Luc De Waal, Antje Margret Wengner, Knut Eis, Philip Lienau, Ulrike Sack, Martin Lange
  • Publication number: 20240190962
    Abstract: The present application relates to immunocytokines comprising a cytokine or variant thereof positioned at the hinge region of a heavy chain of an antibody (e.g., full-length antibody), or positioned at a hinge region between an antigen-binding fragment (e.g., ligand, receptor, or antibody fragment) and an Fc domain subunit or portion thereof, methods of making, and uses thereof.
    Type: Application
    Filed: December 23, 2021
    Publication date: June 13, 2024
    Inventors: Ellen WU, Xiaoyun WU, John WAKEFIELD
  • Publication number: 20240182452
    Abstract: The present invention provides dihydropyridazinone compounds of general formula (I) in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: December 28, 2023
    Publication date: June 6, 2024
    Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Manuel ELLERMANN, Stefan Nikolaus GRADL, Charlotte Christine KOPITZ, Martin LANGE, Adrian TERSTEEGEN, Philip LIENAU, Detlev SÜLZLE, Timothy LEWIS, Heidi GREULICH, Xiaoyun WU, Matthew MEYERSON
  • Patent number: 11974590
    Abstract: The patent discloses halophilic bacteria and a method for fermenting fish paste, belonging to the technical field of solid-state fermentation of aquatic products using microorganisms. Four kinds of screened halophilic bacteria were used as mixed starter culture to produce fish paste. The effects of the ratio of mixed starter culture, inoculation amount, fermentation temperature, fermentation time and salinity on fish paste were studied by determining physical and chemical indexes and performing sensory evaluation. The fish paste has the characteristics of high safety, low salinity, high flavor and nutrition value. This method of fish paste processing needs short fermentation time. The fermented products of fish paste with better flavor can be obtained by using the mixed starter culture.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: May 7, 2024
    Assignee: Jiangsu University
    Inventors: Ruichang Gao, Zhiying Zheng, Li Yuan, Xiaoyun Wu, Qiaozhen Zhou, Qian Chu
  • Publication number: 20240102037
    Abstract: This disclosure provides transgenic plants having enhanced traits such as increased yield, enhanced nitrogen use efficiency and enhanced drought tolerance; propagules, progeny and field crops of such transgenic plants; and methods of making and using such transgenic plants. This disclosure also provides methods of producing hybrid seed from such transgenic plants, growing such seed and selecting progeny plants with enhanced traits. Also disclosed are transgenic plants with altered phenotypes which are useful for screening and selecting transgenic events for the desired enhanced trait.
    Type: Application
    Filed: July 26, 2023
    Publication date: March 28, 2024
    Inventors: Paolo Castiglioni, Jaishree M. Chittoor-Vijayanath, Barry S. Goldman, Robert J. Meister, Monnanda S. Rajani, G. Ramamohan, Naveen Silvester, Tyamagondlu V. Venkatesh, Jingrui Wu, Xiaoyun Wu
  • Patent number: 11912754
    Abstract: The present application provides an antibody fusion protein comprising a vascular endothelial growth factor receptor (VEGFR) fused to the C-terminus of the antibody light chain. Also provided are methods of making and using these antibody fusion proteins.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: February 27, 2024
    Assignee: IMMUNOWAKE INC.
    Inventor: Xiaoyun Wu
  • Publication number: 20240002872
    Abstract: This disclosure provides recombinant DNA constructs and transgenic plants having enhanced traits such as increased yield, increased nitrogen use efficiency and enhanced drought tolerance; propagules, progeny and field crops of such transgenic plants; and methods of making and using such transgenic plants. This disclosure also provides methods of producing seed from such transgenic plants, growing such seed and selecting progeny plants with enhanced traits. Also disclosed are transgenic plants with altered phenotypes which are useful for screening and selecting transgenic events for the desired enhanced trait.
    Type: Application
    Filed: September 18, 2023
    Publication date: January 4, 2024
    Inventors: Mark S. Abad, Erin Bell, Paul S. Chomet, Todd DeZwaan, Stephen M. Duff, Barry S. Goldman, Hongwu Jia, Lloyd Jones, Balasulojini Karunanandaa, Saritha V. Kuriakose, Linda L. Lutfiyya, Savitha Madappa, Zoe P. McKiness, Donald E. Nelson, Sasha Preuss, Monnanda Somaiah Rajani, Dhanalakshmi Ramachandra, Aniruddha Raychaudhuri, Daniel P. Schachtman, Steven H. Schwartz, Char Shobha, Matthew M. Tanzer, Tyamagondlu V. Venkatesh, Huai Wang, Xiaoyun Wu
  • Publication number: 20230416769
    Abstract: The present disclosure provides modified, transgenic, or genome edited/mutated corn plants that are semi-dwarf and have one or more improved ear traits relative to a control plant, such as increase in ear diameter, ear fresh weight, and single kernel weight, and increased yield. The modified, transgenic, or genome edited/mutated corn plants comprise a transgene encoding one or more molybdenum cofactor (Moco) biosynthesis polypeptides and have a reduced expression of one or more GA20 or GA3 oxidase genes. Also provided are methods for producing the modified, transgenic, or genome edited/mutated corn plants.
    Type: Application
    Filed: July 7, 2023
    Publication date: December 28, 2023
    Applicants: Monsanto Technology LLC, BASF Plant Science LP, BASF Plant Science Company GmbH
    Inventors: Charles R. DIETRICH, Natalia IVLEVA, Thomas L. SLEWINSKI, Hong LI, Jaishree CHITTOOR, Xiaoyun WU, Wesley B. BRUCE, Leonardo ALVES-JUNIOR
  • Publication number: 20230405015
    Abstract: The present invention provides a method of treatment of sarcoma comprising administering to a patient in need thereof a compound of general formula (I), in which R1, R2, R3, and R4, are as defined herein, alone or in pharmaceutical compositions or combinations comprising said compounds as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: August 31, 2023
    Publication date: December 21, 2023
    Applicants: Bayer Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Martin LANGE, Stefan KAULFUSS, Charlotte Christine KOPITZ, Heidi GREULICH, Xiaoyun WU, Matthew MEYERSON
  • Publication number: 20230354762
    Abstract: Provided are compositions and methods for reducing, disrupting, or altering ZmDA1 activity in corn plants. Methods and compositions are also provided for producing modifications in the ZmDA1 gene through mutagenesis and/or editing. Modified plant cells and plants having a modification in the ZmDA1 gene are further provided comprising improved characteristics, such as increased yield.
    Type: Application
    Filed: March 27, 2023
    Publication date: November 9, 2023
    Inventors: Steven Beach, Sivalinganna Manjunath, Linda Rymarquis, Thomas L. Slewinski, Xiaoyun Wu
  • Publication number: 20230340517
    Abstract: Provided are compositions and methods for reducing, disrupting, or altering ZmGW2 activity in corn plants. Methods and compositions are also provided for producing modifications in the ZmGW2 gene through mutagenesis and/or editing. Modified plant cells and plants having a modification in the ZmGW2 gene are further provided comprising improved characteristics, such as increased yield.
    Type: Application
    Filed: March 27, 2023
    Publication date: October 26, 2023
    Inventors: Steven Beach, Sivalinganna Manjunath, Linda Rymarquis, Thomas L. Slewinski, Xiaoyun Wu
  • Publication number: 20230313216
    Abstract: Provided are compositions and methods for reducing, disrupting, or altering ZmDA2 activity in corn plants. Methods and compositions are also provided for producing modifications in the ZmDA2 gene through mutagenesis and/or editing. Modified plant cells and plants having a modification in the ZmDA2 gene are further provided comprising improved characteristics, such as increased yield.
    Type: Application
    Filed: March 27, 2023
    Publication date: October 5, 2023
    Inventors: Steven Beach, Sivalinganna Manjunath, Linda Rymarquis, Thomas L. Slewinski, Xiaoyun Wu
  • Patent number: 11773070
    Abstract: The present invention provides dihydrooxydiazinone compounds of general formula (I) in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: July 14, 2022
    Date of Patent: October 3, 2023
    Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Manuel Ellermann, Stefan Nikolaus Gradl, Charlotte Christine Kopitz, Martin Lange, Adrian Tersteegen, Philip Lienau, Christa Hegele-Hartung, Detlev Sülzle, Timothy A. Lewis, Heidi Greulich, Xiaoyun Wu, Matthew Meyerson, Alex Burgin
  • Publication number: 20230167164
    Abstract: The present application relates to immunocytokines comprising a cytokine or variant thereof positioned at the hinge region of a heavy chain of an antibody (e.g., full-length antibody), or positioned at a hinge region between an antigen-binding fragment (e.g., ligand, receptor, or antibody fragment) and an Fc domain subunit or portion thereof, methods of making, and uses thereof.
    Type: Application
    Filed: January 19, 2023
    Publication date: June 1, 2023
    Applicant: Immunowake Inc.
    Inventors: Ellen WU, Xiaoyun WU, John WAKEFIELD
  • Publication number: 20230017200
    Abstract: The present invention provides dihydrooxydiazinone compounds of general formula (I): in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: July 11, 2022
    Publication date: January 19, 2023
    Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Manuel ELLERMANN, Stefan Nikolaus GRADL, Charlotte Christine KOPITZ, Martin LANGE, Adrian TERSTEEGEN, Philip LIENAU, Christa HEGELE-HARTUNG, Detlev SÜLZLE, Timothy A. LEWIS, Heidi GREULICH, Xiaoyun WU, Matthew MEYERSON, Alex BURGIN