Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

Abstract: A rock direct tensile test platform suitable for all material test machines includes a support frame. A top of the support frame is fixed with a top plate, and a bearing plate is provided above the top plate. The bearing plate is provided with a plurality of vertical force transferring rods. The force transferring rods vertically penetrate through the top plate and have a sliding fit with the top plate. Lower ends of the force transferring rods are provided with a tensile base. A top of the tensile base is provided with a lower clamp holder. A bottom of the top plate is provided with an upper clamp holder, and a clamp center of the upper clamp holder coincides with a clamp center of the lower clamp holder.

Abstract: A direct tensile and acoustic testing machine under rock seepage includes a sample and a support frame. A top of the support frame is fixed with a top plate, a bearing plate is provided above the top plate, the bearing plate is provided with a plurality of vertical force transferring rods, the force transferring rods vertically penetrate through the top plate and sliding fit with the top plate, lower ends of the force transferring rods are provided with a tensile base, a top of the tensile base is provided with a lower clamp holder, a bottom of the top plate is provided with an upper clamp holder, and a clamp center of the upper clamp holder overlaps with a clamp center of the lower clamp holder. An acoustic component and a seepage component are provided in the upper clamp holder and the lower clamp holder.

Abstract: A method of planning a travel route includes: receiving a travel route planning request carrying travel parameters sent by a user terminal and determining travel spots of each travel spot type. If the travel parameters include the correlation data between travel spot types and travel time periods, finding the travel spots of the travel spot type corresponding to each travel spot type. If no correlation data is included, dividing a travel cycle specified in the travel parameters into at least one travel time period; computing a corresponding travel spot touring route for each travel time period based on predetermined mapping relationships between the travel spots of each travel spot type, the touring times and distances between different travel spots of the travel spot type; and returning the corresponding travel spot touring route to the user terminal. The present invention further discloses a planning server.

Abstract: A method of planning a travel route includes: receiving a travel route planning request carrying travel parameters sent by a user terminal and determining travel spots of each travel spot type. If the travel parameters include the correlation data between travel spot types and travel time periods, finding the travel spots of the travel spot type corresponding to each travel spot type. If no correlation data is included, dividing a travel cycle specified in the travel parameters into at least one travel time period; computing a corresponding travel spot touring route for each travel time period based on predetermined mapping relationships between the travel spots of each travel spot type, the touring times and distances between different travel spots of the travel spot type; and returning the corresponding travel spot touring route to the user terminal. The present invention further discloses a planning server.

Abstract: A display control method for a side sliding interface, comprising: acquiring a first sliding speed of a slide touch-control point in real time, wherein the slide touch-control point acts on an arbitrary position on the side sliding interface, and the first sliding speed contains a first sliding rate and a first sliding direction; calculating a second sliding rate corresponding to a menu page and a third sliding rate corresponding to a main page according to the first sliding rate, and determining a side sliding direction corresponding to the menu page and the main page according to the first sliding direction; and controlling the menu page and the main page to respectively slide at the second sliding rate and at the third sliding rate correspondingly in the side sliding direction.

Abstract: This Invention Patent application consists of a fabric to be used in textile applications, which makes those items more comfortable and increases their bactericidal capacity, both in the number of types that it fights, and in the time that this capacity is effective, using a mixture of fibers and performing a series of treatments prior to the final manufacture of the textile goods that reinforce the properties of the fabric.

Abstract: This Invention Patent application consists of a fabric to be used in textile applications, which makes those items more comfortable and increases their bactericidal capacity, both in the number of types that it fights, and in the time that this capacity is effective, using a mixture of fibres and performing a series of treatments prior to the final manufacture of the textile goods that reinforce the properties of the fabric.